Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129332-5g | 5g | In stock | $66.90 | |
D129332-25g | 25g | In stock | $301.90 | |
D129332-100g | 100g | In stock | $1,085.90 | |
D129332-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,884.90 |
Potent cyclo-oxygenase inhibitor
Synonyms | Diclofenac sodium | QTG126297Q | Voltaren | 15307-79-6 | Diclofenac sodium salt | Sodium diclofenac | Prophenatin | Neriodin | Diclophenac sodium | GP 45840 | Benfofen | Dyloject | Ecofenac | Abitren | Solaraze | Diclofenac (Sodium) | Diclophlogont | Dealgic | Deflamat | Delphinac | Diclomax | Di |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac. Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), genera |
Shipped In | Normal |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
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IUPAC Name | sodium;2-[2-(2,6-dichloroanilino)phenyl]acetate |
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INCHI | InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
InChi Key | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
Canonical SMILES | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] |
Isomeric SMILES | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] |
WGK Germany | 3 |
RTECS | AG6330000 |
PubChem CID | 5018304 |
UN Number | 2811 |
Packing Group | III |
Molecular Weight | 318.13 |
Reaxy-Rn | 3581138 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2218587 | Certificate of Analysis | Jun 14, 2024 | D129332 |
H2218588 | Certificate of Analysis | Jun 14, 2024 | D129332 |
H2218589 | Certificate of Analysis | Jun 14, 2024 | D129332 |
D2418442 | Certificate of Analysis | Mar 27, 2024 | D129332 |
D2416274 | Certificate of Analysis | Mar 14, 2024 | D129332 |
D2416329 | Certificate of Analysis | Mar 14, 2024 | D129332 |
D2416330 | Certificate of Analysis | Mar 14, 2024 | D129332 |
A2422215 | Certificate of Analysis | Jul 07, 2023 | D129332 |
J2109252 | Certificate of Analysis | Jul 07, 2023 | D129332 |
J2109251 | Certificate of Analysis | Jul 07, 2023 | D129332 |
J2109203 | Certificate of Analysis | Jul 07, 2023 | D129332 |
K2009416 | Certificate of Analysis | Sep 16, 2022 | D129332 |
K2330156 | Certificate of Analysis | Jul 06, 2022 | D129332 |
H2310097 | Certificate of Analysis | Jul 06, 2022 | D129332 |
H2218590 | Certificate of Analysis | Jul 06, 2022 | D129332 |
H2218586 | Certificate of Analysis | Jul 06, 2022 | D129332 |
F2320107 | Certificate of Analysis | Jul 06, 2022 | D129332 |
F2320098 | Certificate of Analysis | Jul 06, 2022 | D129332 |
F2320078 | Certificate of Analysis | Jul 06, 2022 | D129332 |
C2225038 | Certificate of Analysis | Apr 06, 2022 | D129332 |
Solubility | Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (~35 mg/ml), DMF (~35 mg/ml), DMSO (~35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml). |
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Melt Point(°C) | 283-285°C |
Pictogram(s) | GHS06, GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | AG6330000 |
Reaxy-Rn | 3581138 |
Class | 6.1 |
Merck Index | 3081 |
1. Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang. (2024) Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis. JOURNAL OF CONTROLLED RELEASE, 365 (274). [PMID:37979695] |
2. Guang-Rong Wu, Jia-Kun Xu, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin. (2023) Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. Journal of Environmental Chemical Engineering, 11 (17): (111471). [PMID:9751059] |
3. Jieling Song, Wen Liu, Zhaokun Xiong, Bo Lai, Rongfu Huang. (2024) Understanding the multiple functions of the electrolyte tetrapolyphosphate in Electro-Fenton system for effective removal of diclofenac. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (20): (125327). [PMID:9435236] |
4. Yang Zong, Hua Zhang, Hao Liu, Jun Xu, Zhengwei Zhou, Xiaomeng Zhang, Ting Zhang, Deli Wu. (2023) Selective abatement of electron-rich organic contaminants by trace complexed Mn(II)-catalyzed periodate via high-valent manganese–oxo species. JOURNAL OF HAZARDOUS MATERIALS, 460 (132447). [PMID:37677971] |
5. Hongrui Yang, Chen Wang, Wenjuan Zhu, Pingning Jin, Fei Li, Jing Fan. (2023) A Carboxyl Group-Functionalized Ionic Liquid Hybrid Adsorbent for Solid-Phase Extraction and Determination of Trace Diclofenac Sodium in Milk Samples. MOLECULES, 28 (17): (6216). [PMID:37687045] |
6. Gholipour Arsalan, Jahanshahi Mohsen, Emadi Hamid. (2023) Synthesis of Carbon Quantum Dots and Fe-Doped Carbon Quantum Dots as Fluorescent Probes via One-Step Microwave Process for Rapid and Accurate Detection of Diclofenac Sodium. JOURNAL OF CLUSTER SCIENCE, (1-15). [PMID:] |
7. Jieli Ou, Jiewen Deng, Zhenran Wang, Yongsheng Fu, Yiqing Liu. (2023) Heat induced superfast diclofenac removal in Cu(II)–activated peracetic acid system: Mediation from non-radical to radical pathway. CHEMOSPHERE, 338 (139528). [PMID:37459928] |
8. Kunhui Sun, Bing Wang, Jiaoli Lin, Lei Han, Meifang Li, Ping Wang, Xiean Yu, Jiangwei Tian. (2023) A Multichannel Fluorescent Array Sensor for Discrimination of Different Types of Drug-Induced Kidney Injury. SENSORS, 23 (13): (6114). [PMID:37447963] |
9. Jia Zhao, Heng Zhang, Yang Shi, Mengfan Luo, Hongyu Zhou, Zhenjun Xie, Ye Du, Peng Zhou, Chuanshu He, Gang Yao, Bo Lai. (2023) Efficient activation of ferrate by Ru(III): Insights into the major reactive species and the multiple roles of Ru(III). JOURNAL OF HAZARDOUS MATERIALS, 458 (131927). [PMID:37379593] |
10. Jiewen Deng, Jieli Ou, Zhenran Wang, Yongsheng Fu, Yiqing Liu. (2023) Phosphate enhanced Cu(II)/peracetic acid process for diclofenac removal: Performance and mechanism. ENVIRONMENTAL RESEARCH, 232 (116340). [PMID:37290624] |
11. Qianli Li, Yi Hou, Pinyin Cao, Ruiye Bi, Songsong Zhu. (2023) Near-Infrared Light-Activated Mesoporous Polydopamine for Temporomandibular Joint Osteoarthritis Combined Photothermal-Chemo Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (10): (9055). [PMID:37240401] |
12. Zijun Zhang, Qiuyang Zhang, Shuna Gao, Hui Xu, Jiangna Guo, Feng Yan. (2023) Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection. Acta Biomaterialia, 166 (254). [PMID:37187300] |
13. Yu Yu, Wang Miao, Li Xiao-Wei, Mao Jie, Zhu Ying-Jie, Wang Na, Yin Le-Hua, Guo Zeng-Lin, Cai Hong, Li Tao, Liang Ting-Ting, Cui Jiuwei, Zhou Tao. (2023) Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses. Cell and Bioscience, 13 (1): (1-10). [PMID:37120570] |
14. Liwei Yang, Fashan Yang, Heng Zhang, Hongyu Zhou, Mengfan Luo, Yunmei Liu, Chuanliang Zhao, Lu Zheng, Bo Lai. (2023) Insight into the electron transfer regime of periodate activation on MnO2: The critical role of surface Mn(IV). JOURNAL OF HAZARDOUS MATERIALS, 454 (131479). [PMID:37104949] |
15. Wenying Zou, Junjun Wang, Siyi Yang, Yue Tang, Xiaojuan Niu, Yuangen Wu. (2023) Porous-nanozyme-based colorimetric sensor for rapid detection of kanamycin in foods under neutral condition. JOURNAL OF FOOD SCIENCE, 88 (5): (2009-2022). [PMID:37043597] |
16. Junjing Li, Yu Wang, Bin Zhao, Jing Ding, Jun Zhang, Menghua Yin, Zhaohui Zhang, Shumin Ma, Yaqian Liu, Zilin Tan, Hongwei Zhang, Liang Wang, Dionysios D. Dionysiou. (2023) Unraveling kinetics and mechanism of electrocatalytic hydrodechlorination of chlorinated PPCPs by nickel-cobalt metal organic framework supported palladium composite electrode. APPLIED CATALYSIS B-ENVIRONMENTAL, 332 (122754). [PMID:] |
17. Can Feng, Heng Zhang, Yi Ren, Mengfan Luo, Siying Yu, Zhaokun Xiong, Yang Liu, Peng Zhou, Bo Lai. (2023) Enhancing zerovalent iron-based Fenton-like chemistry by copper sulfide: Insight into the active sites for sustainable Fe(II) supply. JOURNAL OF HAZARDOUS MATERIALS, 452 (131355). [PMID:37027922] |
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19. Zhentao Li, Zhengzheng Liao, Jinfang Hu, Zilin Chen. (2023) In situ growth of imine-based covalent organic framework as stationary phase for high-efficiency electrochromatographic separation. JOURNAL OF CHROMATOGRAPHY A, 1694 (463905). [PMID:36881971] |
20. Nan Li, Lanlan Huo, Wenjing Shen, Chenghong Qiang, Mianmian Wu, Guifang Sun, Qingfei Li, Minghao Shi, Jiangquan Ma. (2023) Porous organic polymers for superefficient removal of pollutants from water: Design, synthesis and adsorption performance. Journal of Cleaner Production, 396 (136558). [PMID:] |
21. Bing Liu, Xia Zhang, Jialong Chu, Fei Li, Caixia Jin, Jing Fan. (2023) 2D/2D BiOIO3/Ti3C2 MXene nanocomposite with efficient charge separation for degradation of multiple pollutants. APPLIED SURFACE SCIENCE, 618 (156565). [PMID:] |
22. Wei Wang, Minjuan Gong, Donghai Zhu, Mohammadtaghi Vakili, Zahra Gholami, Huanhuan Jiang, Shuangxi Zhou, Han Qu. (2023) Post-synthetic thiol modification of covalent organic frameworks for mercury(II) removal from water. Environmental Science and Ecotechnology, 14 (100236). [PMID:36793397] |
23. Fangzhe Liu, Zihan Wang, Hui Guo, Haichao Li, Yulan Chen, Shuang Guan. (2023) A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery. MOLECULES, 28 (2): (499). [PMID:36677557] |
24. Min Tao, Jian Zhang, Jiliang Lv, Jiaquan Zhang, Yuxiao Li, Shan Liu, Wensheng Xiao, Ying Huang, Han Zheng. (2023) Highly efficient activation of sulfite by surface oxidized pyrite for atrazine degradation: Experimental and DFT study. Journal of Environmental Chemical Engineering, 11 (109200). [PMID:] |
25. Jie Zhao, Yunning Chen, Renquan Guan, Xueying Cheng, Zhengkai Wu, Nana Zhao, Qingkun Shang, Yingnan Sun. (2023) Enhancement of water soluble PDI-NapSO3H on the photocatalytic performance of Fe-TiO2 under visible light. SEPARATION AND PURIFICATION TECHNOLOGY, 307 (122801). [PMID:] |
26. Hao-Ze Li, Cheng Yang, Hai-Long Qian, Xiu-Ping Yan. (2023) Room-temperature synthesis of ionic covalent organic frameworks for efficient removal of diclofenac sodium from aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122704). [PMID:] |
27. Hui Wang, Jinming Liu, Xu Fan, Jing Ren, Qian Liu, Baohua Kong. (2022) Fabrication, characterisation, and application of green crosslinked sodium alginate hydrogel films by natural crab-shell powders to achieve drug sustained release. LWT-FOOD SCIENCE AND TECHNOLOGY, 171 (114147). [PMID:] |
28. Xu Wang, Lingwen Dong, Guode Zhao, Weiwei Li, Ying Peng, Jiang Zheng. (2022) 2,3,5,4′-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo. CHEMICO-BIOLOGICAL INTERACTIONS, 368 (110234). [PMID:36332690] |
29. Wang Chunyan, Hou Yaqi, Wang Xingyi, Li Weijun, Zhang Yunmao, Wang Shuli, Zheng Jing, Hou Xu. (2022) Structural and Interfacial Effects on Drug Release Kinetics of Liquid-Based Fibrous Catheter. Advanced Fiber Materials, 4 (6): (1645-1655). [PMID:] |
30. He Haonan, Zhao Junfeng. (2023) The efficient degradation of diclofenac by ferrate and peroxymonosulfate: performances, mechanisms, and toxicity assessment. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (5): (11959-11977). [PMID:36103067] |
31. Ying Wang, Yue Yang, Zhiyuan Zha, Jixiao Wang, Zhi Wang, Song Zhao. (2022) Porous organic cage supramolecular membrane showing superior monovalent/divalent salts separation. JOURNAL OF MEMBRANE SCIENCE, 659 (120782). [PMID:] |
32. Weiyingxue Yang, Chuixiu Huang, Xiantao Shen. (2022) Water-compatible Janus molecularly imprinted particles with mouth-like opening: Rapid removal of pharmaceuticals from hospital effluents. CHEMOSPHERE, 304 (135350). [PMID:35714963] |
33. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie. (2022) Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food. Food Bioscience, 49 (101842). [PMID:] |
34. Yingfei Wang, Junhui Zhou, Fengliang Wang, Yi Xie, Shengwei Liu, Zhimin Ao, Chuanhao Li. (2022) Hydrogen generation from photocatalytic treatment of wastewater containing pharmaceuticals and personal care products by Oxygen-doped crystalline carbon nitride. SEPARATION AND PURIFICATION TECHNOLOGY, 296 (121425). [PMID:] |
35. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen. (2022) Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs. TALANTA, 246 (123485). [PMID:35462249] |
36. Wu Yusheng, Qin Dongmiao, Meng Shuo, Zhang Chuqing, Deng Biyang. (2022) Carbon quantum dots with blue/near infrared emissions for ratiometric fluorescent lornoxicam sensing and bio-imaging. MICROCHIMICA ACTA, 189 (4): (1-11). [PMID:35347472] |
37. Jiewen Deng, Shenglan Liu, Yongsheng Fu, Yiqing Liu. (2023) Heat-activated peracetic acid for degradation of diclofenac: kinetics, influencing factors and mechanism. ENVIRONMENTAL TECHNOLOGY, 44 (19): (2946-2954). [PMID:35225731] |
38. Zhimin Guo, Nan Li, Shixiang Zuo, Chenghong Qiang, Wei Zhan, Zhengping Li, Jiangquan Ma. (2022) Construction of a novel metal–organic framework adenine-UiO-66 piezocatalyst for efficient diclofenac removal. SEPARATION AND PURIFICATION TECHNOLOGY, 289 (120743). [PMID:] |
39. Ying Wang, Song Zhao, Zhiyuan Zha, Zhi Wang, Jixiao Wang. (2022) Host-guest nanofiltration membranes having amino-complexed cucurbituril supramolecular channel for monovalent/divalent salts separation. DESALINATION, 527 (115582). [PMID:] |
40. Zhendong Yu, Jiachen Ma, Xiaoyi Huang, Yuancai Lv, Yifan Liu, Chunxiang Lin, Rongni Dou, Xiaoxia Ye, Yongqian Shi, Minghua Liu. (2022) Insights into enhanced peroxydisulfate activation with S doped Fe@C catalyst for the rapid degradation of organic pollutants. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 610 (24). [PMID:34920214] |
41. Zhaohan Wei, Xiaoqiong Zhang, Zelong Zhang, Tuying Yong, Guiting Zhan, Weilin Lv, Ziqiao Ding, Kaili Sun, Xiangliang Yang, Lu Gan. (2022) Engineered Iron-Based nanoplatform amplifies repolarization of M2-Like Tumor-Associated Macrophages for enhanced cancer immunotherapy. CHEMICAL ENGINEERING JOURNAL, 433 (133847). [PMID:] |
42. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. (2022) Successive liquid-phase microextraction of acidic and basic analytes. ANALYTICA CHIMICA ACTA, 1192 (339335). [PMID:35057942] |
43. Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang. (2022) A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing. JOURNAL OF CONTROLLED RELEASE, 341 (147). [PMID:34813880] |
44. Yizhou Tu, Huimin Wang, Pingping Yang, Guizhou Xu, Xuejiao Hu, Aimin Li, Xianchuan Xie. (2022) A porous thienyl cyclodextrin polymer synthesized in a homogeneous ionic liquid catalytic system for the rapid removal of pharmaceuticals and personal care products (PPCPs). GREEN CHEMISTRY, 24 (1): (227-237). [PMID:] |
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