Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D109025-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
D109025-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $66.90 | |
D109025-25g | 25g | In stock | $232.90 | |
D109025-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $649.90 |
Synonyms | DES | 4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | Diethylstilbesterol | Makarol | Stilbofolin | 4,4'-(Hex-3-ene-3,4-diyl)diphenol | Climaterine | Distilbene | Oestromensyl | (E)-4,4'-(hex-3-ene-3,4-diyl)diphenol | neo-Oestranol 1 | New-Estranol 1 | |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive a |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β;Antagonist of Estrogen-related receptor-α;Antagonist of Estrogen-related receptor-β;Antagonist of Estrogen-related receptor-γ |
ALogP | 5.1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol |
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INCHI | InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+ |
InChi Key | RGLYKWWBQGJZGM-ISLYRVAYSA-N |
Canonical SMILES | CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O |
Isomeric SMILES | CC/C(=C(/CC)\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)O |
WGK Germany | 3 |
PubChem CID | 448537 |
UN Number | 3077 |
Packing Group | III |
Molecular Weight | 268.35 |
Beilstein | 2056095 |
ChEBI | CHEBI:41922 |
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PubChem CID | 448537 |
ChEMBL Ligand | CHEMBL411 |
BindingDB Ligand | 20625 |
Wikipedia | Diethylstilbestrol |
CAS Registry No. | 56-53-1 |
NURSA Ligand | 10.1621/GYGXGQW5SL |
RCSB PDB Ligand | DES |
DrugCentral Ligand | 875 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2421343 | Certificate of Analysis | Nov 09, 2024 | D109025 |
K2421344 | Certificate of Analysis | Nov 09, 2024 | D109025 |
K2421384 | Certificate of Analysis | Nov 09, 2024 | D109025 |
K2421385 | Certificate of Analysis | Nov 09, 2024 | D109025 |
K2428322 | Certificate of Analysis | Nov 09, 2024 | D109025 |
A2405083 | Certificate of Analysis | Jan 10, 2024 | D109025 |
C2030037 | Certificate of Analysis | Oct 12, 2023 | D109025 |
C2218538 | Certificate of Analysis | Jan 22, 2022 | D109025 |
C2218539 | Certificate of Analysis | Jan 22, 2022 | D109025 |
C2218548 | Certificate of Analysis | Jan 22, 2022 | D109025 |
Melt Point(°C) | 169-172°C |
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Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H360:May damage fertility or the unborn child H350:May cause cancer |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Class | 9 |
1. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] [10.1016/j.microc.2023.109524] |
2. Min Jia, Fupei Xu, Fei Zhai, Xiaoying Yu, Meixia Du. (2023) An all-in-one portable colorimetric detection platform for sensitive detection of bisphenol A based on target-mediated CeO2@ZIF-8/Apt biocomposites. JOURNAL OF COLLOID AND INTERFACE SCIENCE, (10): [PMID:37845127] [10.1016/j.jcis.2023.10.055] |
3. Lixia Lu, Bingchan Song, Jianwen Gao, Xinyu Shao. (2023) A ratiometric aptasensor for simultaneous determination of two estrogens based on multicolor upconversion nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 389 (133842). [PMID:] [10.1016/j.snb.2023.133842] |
4. Jiameng Liu, Mengfei Wang, Chuanpan Guo, Zheng Tao, Minghua Wang, Linghao He, Baozhong Liu, Zhihong Zhang. (2023) Defective porphyrin-based metal-organic framework nanosheets derived from V2CTx MXene as a robust bioplatform for impedimetric aptasensing 17β-estradiol. FOOD CHEMISTRY, 416 (135839). [PMID:36893636] [10.1016/j.foodchem.2023.135839] |
5. Lixia Lu, Xinyu Shao, Jianwen Gao, Bingchan Song, Linhe Ding, Jianhua Zhou. (2023) Surface plasmon field enhanced upconversion luminescence for the screening and detection of phenolic environmental estrogens. FOOD CHEMISTRY, 413 (135606). [PMID:36773364] [10.1016/j.foodchem.2023.135606] |
6. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan. (2022) Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36416994] [10.1007/s00604-022-05572-3] |
7. Qingyuan Song, Xueling Shan, Liyin Bu, Anna Dai, Ding Jiang, Wenchang Wang, Hiroshi Shiigi, Zhidong Chen. (2023) An electrochemiluminescence resonance energy aptasensor based on Ag3PO4-UiO-66 for ultrasensitive detection of diethylstilbestrol. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 928 (116987). [PMID:] [10.1016/j.jelechem.2022.116987] |
8. Ruozhu Xu, Yuan Tao, Wang Yao, Honglin Qin, Lizhen Qiao. (2022) Three-dimensional flower-like SnS2 materials for dispersive solid-phase extraction of endocrine-disrupting phenols. JOURNAL OF SEPARATION SCIENCE, 45 (23): (4224-4235). [PMID:36189856] [10.1002/jssc.202200419] |
9. Wenjing Wang, Fei Zhai, Fupei Xu, Min Jia. (2022) Enzyme-free amplified and one-step rapid detection of bisphenol A using dual-terminal labeled split aptamer probes. MICROCHEMICAL JOURNAL, 183 (107977). [PMID:] [10.1016/j.microc.2022.107977] |
10. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan. (2023) MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing. JOURNAL OF HAZARDOUS MATERIALS, 442 (130000). [PMID:36137886] [10.1016/j.jhazmat.2022.130000] |
11. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants. MICROCHEMICAL JOURNAL, 182 (107933). [PMID:] [10.1016/j.microc.2022.107933] |
12. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
13. Zhang Qianchun, Wang Yutong, Yang Bingnian, Bao Linchun, Wu Yun, Wang Xingyi. (2022) Development of an Efficient Solid-Phase Microextraction Monolithic Column for the Analysis of Estrogens in Human Urine and Serum Samples. CHROMATOGRAPHIA, 85 (8): (733-741). [PMID:] [10.1007/s10337-022-04178-4] |
14. Tong Liao, Jia Jia, Kang Tong, Jiuhong Ouyang, Wei Jiang, Xia-ping Zhu. (2022) Determination of synthetic estrogens in milk by a novel hyper-crosslinked polymer SPME coupled with HPLC-MS. MICROCHEMICAL JOURNAL, 181 (107700). [PMID:] [10.1016/j.microc.2022.107700] |
15. Yang Zhenglun, Chen Yihui, Jia Jianggang, Hou Chunyan, Xuan Rongrong, Wang Tingting. (2022) C18-modified halloysite as a novel sorbent in matrix solid-phase dispersion for the extraction of bisphenol A and diethylstilbestrol from human placenta. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (17): (4897-4907). [PMID:35595839] [10.1007/s00216-022-04114-3] |
16. Jin Liu, Xuhong Cai, Junbo Liu, Dadong Liang, Kaiyin Chen, Shanshan Tang, Bao Xu. (2022) Study on the Preparation of Estrone Molecularly Imprinted Polymers and Their Application in a Quartz Crystal Microbalance Sensor via a Computer-Assisted Design. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (10): (5758). [PMID:35628568] [10.3390/ijms23105758] |
17. Ruiting Sun, Fuwei Lu, Chunmei Yu, Yanan Yang, Lizhen Qiao, Anmin Liu. (2022) Peanut shells-derived biochars as adsorbents for the pipette-tip solid-phase extraction of endocrine-disrupting phenols in water, milk and beverage. JOURNAL OF CHROMATOGRAPHY A, 1673 (463101). [PMID:35525193] [10.1016/j.chroma.2022.463101] |
18. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen. (2022) Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction. MOLECULES, 27 (7): (2353). [PMID:35408750] [10.3390/molecules27072353] |
19. Yan Wu, Kaixing Luo, Yanjuan Liu, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Innovative preparation of ureido/dodecyl dual-functionalized silica as a versatile mixed-mode stationary phase for high-resolution chromatographic separations. JOURNAL OF CHROMATOGRAPHY A, 1665 (462834). [PMID:35085896] [10.1016/j.chroma.2022.462834] |
20. Mingxia Sun, Juanjuan Feng, Jiaqing Feng, Haili Sun, Yang Feng, Xiangping Ji, Chunying Li, Sen Han, Min Sun. (2022) Biochar nanosphere- and covalent organic framework nanosphere-functionalized titanium dioxide nanorod arrays on carbon fibers for solid-phase microextraction of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 433 (133645). [PMID:] [10.1016/j.cej.2021.133645] |
21. Qingyi Wei, Peiyao Zhang, Hongbin Pu, Da-Wen Sun. (2022) A fluorescence aptasensor based on carbon quantum dots and magnetic Fe3O4 nanoparticles for highly sensitive detection of 17β-estradiol. FOOD CHEMISTRY, 373 (131591). [PMID:34823936] [10.1016/j.foodchem.2021.131591] |
22. Yi Zhang, Jie Zhou, Xiao-Xiao Zhang, Wen-Long Wang, Cheng Yang, Xueli Shi, Yong-Wei Feng, Renagul Abdurahman. (2022) NIR persistent luminescence nanoparticles based turn-on aptasensor for autofluorescence-free determination of 17β-estradiol in milk. FOOD CHEMISTRY, 373 (131432). [PMID:34717086] [10.1016/j.foodchem.2021.131432] |
23. Wenbin Wang, Peipei Li, Zhixian Zheng, Di Cheng, Chengming Dong, Huaixia Yang. (2021) Highly sensitive fluorescence detection of tobacco mosaic virus RNA based on disodium 4,4′-diazidostilbene-2,2′-disulfonate tetrahydrate in situ reaction. NEW JOURNAL OF CHEMISTRY, 45 (34): (15240-15246). [PMID:] [10.1039/D1NJ02546E] |
24. Xiaoxiao Zhu, Yijun Zhang, Pengfei Liu, Xiuzhi Bai, Na Chen, Yuping Zhang. (2021) Carbonized Aramid Fiber as the Adsorbent for In-Tube Solid-Phase Microextraction to Detect Estrogens in Water Samples. Journal of Chemistry, 2021 (9970518). [PMID:] [10.1155/2021/9970518] |
25. Yi Zhang, Lingling Wang, Wen-Long Wang, Cheng Yang, Yongwei Feng, Xueli Shi. (2021) Visual-afterglow dual-mode immunochromatographic strip for 17β-estradiol detection in milk. TALANTA, 232 (122427). [PMID:34074413] [10.1016/j.talanta.2021.122427] |
26. Hui Lv, Juanjuan Wang, Mingying Wang, Li Shen, Ling Xiao, Taijie Chen, Tingzhe Sun, Wenjuan Li, Liangliang Zhu, Xiaoke Zhang. (2021) Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions. FOOD AND CHEMICAL TOXICOLOGY, 149 (112039). [PMID:33549631] [10.1016/j.fct.2021.112039] |
27. Xiangqiong Jiang, Guihua Ruan, Wenjuan Zhang, Yan Zhang, Fuyou Du, Zhengyi Chen. (2020) Preparation of porous polymers based on high internal phase emulsion for enrichment of estrogens in urine. JOURNAL OF SEPARATION SCIENCE, 44 (6): (1140-1147). [PMID:32725854] [10.1002/jssc.202000566] |
28. Xing Tian, Huijia Song, Yue Wang, Xuemeng Tian, Yuhai Tang, Ruixia Gao, Chengxiao Zhang. (2020) Hydrophilic magnetic molecularly imprinted nanobeads for efficient enrichment and high performance liquid chromatographic detection of 17beta-estradiol in environmental water samples. TALANTA, 220 (121367). [PMID:32928396] [10.1016/j.talanta.2020.121367] |
29. Huihuang Xiong, Lan Guo, Xuejin Mao, Ting Tan, Hao Wan, Yiqun Wan. (2020) A magnetic hydrophilic molecularly imprinted material with multiple stimuli-response properties for efficient recognition of bisphenol A in beverages. FOOD CHEMISTRY, 331 (127311). [PMID:32569967] [10.1016/j.foodchem.2020.127311] |
30. Shasha Pang, Xianwen Kan. (2020) One-pot synthesis of nitrogen doped graphene-thionine-gold nanoparticles composite for electrochemical sensing of diethylstilbestrol and H2O2. MICROCHEMICAL JOURNAL, 157 (104924). [PMID:] [10.1016/j.microc.2020.104924] |
31. Yuhan Zhu, Zuwei Xu, Jie Gao, Weihao Ji, Jingdong Zhang. (2020) An antibody-aptamer sandwich cathodic photoelectrochemical biosensor for the detection of progesterone. BIOSENSORS & BIOELECTRONICS, 160 (112210). [PMID:32339148] [10.1016/j.bios.2020.112210] |
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