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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D114530-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $206.90 |
Potent insect growth regulator
Synonyms | AS-15364 | Benzamide, N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluoro- | N-{[(4-chlorophenyl)amino]carbonyl}-2,6-difluorobenzamide | AI3-29054 | Cambridge id 5259978 | HSDB 6611 | Diflubenzuron;N-[[(4-Chlorophenyl)amino]carbonyl]-2,6-di-fluorobenzamide;1 |
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Specifications & Purity | analytical standard |
Biochemical and Physiological Mechanisms | Potent insect growth regulator (IC 50 = 36 nM). Inhibits chitin synthetase and disrupts molting. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Diflubenzuron is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-[(4-chlorophenyl)carbamoyl]-2,6-difluorobenzamide |
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INCHI | InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21) |
InChi Key | QQQYTWIFVNKMRW-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F |
Isomeric SMILES | C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F |
WGK Germany | 2 |
RTECS | YS6200000 |
PubChem CID | 37123 |
UN Number | 3077 |
Packing Group | III |
Molecular Weight | 310.68 |
Beilstein | 2162461 |
Enter Lot Number to search for COA:
Solubility | Soluble in methanol, DMSO, acetone (6.5 mg/ml at 20 °C), and ethanol. Insoluble in water. |
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Melt Point(°C) | 230-232°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H312:Harmful in contact with skin H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P317:Get emergency medical help. |
WGK Germany | 2 |
RTECS | YS6200000 |
Class | 9 |
Starting at $59.90
Starting at $52.90
Starting at $59.90
Starting at $69.90
1. Beibei Zhao, Xinfang Liu, Zheng Cheng, Xu Liu, Xiaoyu Zhang, Xun Feng. (2024) Smartphone-integrated paper-based sensing platform for the visualization and quantitative detection of pymetrozine. FOOD CHEMISTRY, 440 (138269). [PMID:38157705] |
2. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Zhimin Yang, Shuai Wang, Yong Guo. (2024) Preparation and extraction property study of corn cob-like magnetic mosaic carbon materials derived from MOF-on-MOF composites. ANALYTICA CHIMICA ACTA, 1287 (342112). [PMID:38182348] |
3. Li Dan, Gao Yanmei, Mu Mengyao, Zhu Shiping, Zhang Ning, Lu Minghua. (2023) Ionic liquid-modified UiO-66-NH2 as sorbent of dispersive solid-phase extraction for rapid adsorption and enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 190 (11): (1-11). [PMID:37853180] |
4. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259] |
5. Xian-Xian Ji, Yu-Long Liu, Xin-Yue Chang, Rui-Long Li, Fei Ye, Liu Yang, Ying Fu. (2023) An electrochemical sensor derived from Cu-BTB MOF for the efficient detection of diflubenzuron in food and environmental samples. FOOD CHEMISTRY, 428 (136802). [PMID:37421661] |
6. Juntao Wang, Jiajia Liu, Weihua Liu, Ziwang Liu, Qiuhua Wu, Zhi Wang, Hongyuan Yan. (2023) A phenyl-functionalized nitrogen-rich magnetic hyper crosslinked polymer for magnetic solid-phase extraction of 5-nitroimidazoles residues in water and fish samples. MICROCHEMICAL JOURNAL, 191 (108936). [PMID:] |
7. Mengyao Mu, Shiping Zhu, Yanmei Gao, Ning Zhang, Youmei Wang, Minghua Lu. (2023) Construction of hierarchically porous metal-organic framework HP-UiO-66-30% for sensitive determination of benzoylurea insecticides. TALANTA, 260 (124540). [PMID:37116361] |
8. Honglei Zhao, Ruotong Li, Jiye Hu. (2023) Frequently used pesticides and their metabolites residues in apple and apple juice from markets across China: Occurrence and health risk assessment. LWT-FOOD SCIENCE AND TECHNOLOGY, 178 (114610). [PMID:] |
9. Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang. (2022) Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): (11932). [PMID:36233243] |
10. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Yong Guo, Licheng Wang, Shuai Wang. (2022) Extraction of benzoylurea insecticides from tea leaves based on thermoplastic polyethyleneimine embedded magnetic nanoparticle carbon materials. JOURNAL OF CHROMATOGRAPHY A, 1681 (463476). [PMID:36088774] |
11. Cong Zhang, Wenfeng Hu, Zhuo Yu, Xian Liu, Jing Wang, Tianrong Xin, Zhiwen Zou, Bin Xia. (2022) Characterization of Chitin Synthase A cDNA from Diaphorina citri (Hemiptera: Liviidae) and Its Response to Diflubenzuron. Insects, 13 (8): (728). [PMID:36005353] |
12. Ling Mei, Tiantian Si, Shuai Wang, Jie Zhu, Hao Tang, Xiaojing Liang. (2022) TiO2@MOF-919(Fe–Cu) as a sorbent for the extraction of benzoylurea pesticides from irrigation water and fruit juices. Analytical Methods, 14 (33): (3153-3159). [PMID:35929513] |
13. Min Li, Weihua Liu, Xufeng Meng, Shuofeng Li, Qianqian Wang, Yaxing Guo, Yuanyuan Wu, Lin Hao, Xiumin Yang, Zhi Wang, Chun Wang, Qiuhua Wu. (2022) Facile synthesis of magnetic hypercrosslinked polymer for the magnetic solid-phase extraction of benzoylurea insecticides from honey and apple juice samples. FOOD CHEMISTRY, 395 (133596). [PMID:35792491] |
14. Shuofeng Li, Weihua Liu, Qianqian Wang, Mingming Xu, Yangjuan An, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2022) Constructing magnetic covalent organic framework EB-COF@Fe3O4 for sensitive determination of five benzoylurea insecticides. FOOD CHEMISTRY, 382 (132362). [PMID:35152018] |
15. Weihua Liu, Juntao Wang, Shuangju Song, Lin Hao, Jiajia Liu, Yangjuan An, Yaxing Guo, Qiuhua Wu, Chun Wang, Zhi Wang. (2022) Facile synthesis of uniform spherical covalent organic frameworks for determination of neonicotinoid insecticides. FOOD CHEMISTRY, 367 (130653). [PMID:34343809] |
16. Chaoran Liu, Xiaodong Huang, Zilin Meng, Heng Qian, Xinya Liu, Runhua Lu, Wenfeng Zhou, Haixiang Gao, Donghui Xu. (2020) Study on the adsorption mechanism of benzoylurea insecticides onto modified hyperbranched polysilicon materials. RSC Advances, 10 (48): (28664-28673). [PMID:35520092] |
17. Qianqian Wang, Weihua Liu, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2020) Fabrication of magnetic porous organic framework for effective enrichment and assay of nitroimidazoles in chicken meat. FOOD CHEMISTRY, 332 (127427). [PMID:32619936] |
18. Jiaxuan Fan, Zikai Liu, Jing Li, Wenfeng Zhou, Haixiang Gao, Sanbing Zhang, Runhua Lu. (2020) PEG-modified magnetic Schiff base network-1 materials for the magnetic solid phase extraction of benzoylurea pesticides from environmental water samples. JOURNAL OF CHROMATOGRAPHY A, 1619 (460950). [PMID:32061359] |
19. Duo Huixiao, Li Yijing, Liang Xiaojing, Wang Shuai, Wang Licheng, Guo Yong. (2020) Magnetic 3D hierarchical Ni/NiO@C nanorods derived from metal-organic frameworks for extraction of benzoylurea insecticides prior to HPLC-UV analysis. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31897612] |
20. Huixiao Duo, Xiaofeng Lu, Shuai Wang, Licheng Wang, Yong Guo, Xiaojing Liang. (2019) Synthesis of magnetic metal–organic framework composites, Fe3O4-NH2@MOF-235, for the magnetic solid-phase extraction of benzoylurea insecticides from honey, fruit juice and tap water samples. NEW JOURNAL OF CHEMISTRY, 43 (32): (12563-12569). [PMID:] |
21. Xiaolan Wang, Xufeng Meng, Qiuhua Wu, Chun Wang, Zhi Wang. (2019) Solid phase extraction of carbamate pesticides with porous organic polymer as adsorbent followed by high performance liquid chromatography-diode array detection. JOURNAL OF CHROMATOGRAPHY A, 1600 (9). [PMID:31010634] |
22. Xinyu Liang, Juntao Wang, Qiuhua Wu, Chun Wang, Zhi Wang. (2018) Use of a hypercrosslinked triphenylamine polymer as an efficient adsorbent for the enrichment of phenylurea herbicides. JOURNAL OF CHROMATOGRAPHY A, 1538 (1). [PMID:29397984] |
23. Xinyu Liang, Ruiyang Ma, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2018) β-Cyclodextrin polymer@Fe3O4 based magnetic solid-phase extraction coupled with HPLC for the determination of benzoylurea insecticides from honey, tomato, and environmental water samples. JOURNAL OF SEPARATION SCIENCE, 41 (7): (1539-1547). [PMID:29280564] |
24. Wang Juntao, Jiao Caina, Li Menghua, Wang Xiaolan, Wang Chun, Wu Qiuhua, Wang Zhi. (2018) Porphyrin based porous organic polymer modified with Fe3O4 nanoparticles as an efficient adsorbent for the enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 185 (1): (1-8). [PMID:29594549] |
25. Songqing Li, Lu Hu, Ketao Chen, Haixiang Gao. (2015) Extensible automated dispersive liquid–liquid microextraction. ANALYTICA CHIMICA ACTA, 872 (46). [PMID:25892068] |
26. Jiaheng Zhang, Zhe Liang, Songqing Li, Yubo Li, Bing Peng, Wenfeng Zhou, Haixiang Gao. (2012) In-situ metathesis reaction combined with ultrasound-assisted ionic liquid dispersive liquid–liquid microextraction method for the determination of phenylurea pesticides in water samples. TALANTA, 98 (145). [PMID:22939140] |
27. Hui Yun,Bin Liang,Jiguo Qiu,Long Zhang,Youkang Zhao,Jiandong Jiang,Aijie Wang. (2016-12-15) Functional Characterization of a Novel Amidase Involved in Biotransformation of Triclocarban and its Dehalogenated Congeners in Ochrobactrum sp. TCC-2.. Environmental science & technology, 51 ((1)): (291-300). [PMID:27966913] |
1. Beibei Zhao, Xinfang Liu, Zheng Cheng, Xu Liu, Xiaoyu Zhang, Xun Feng. (2024) Smartphone-integrated paper-based sensing platform for the visualization and quantitative detection of pymetrozine. FOOD CHEMISTRY, 440 (138269). [PMID:38157705] |
2. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Zhimin Yang, Shuai Wang, Yong Guo. (2024) Preparation and extraction property study of corn cob-like magnetic mosaic carbon materials derived from MOF-on-MOF composites. ANALYTICA CHIMICA ACTA, 1287 (342112). [PMID:38182348] |
3. Li Dan, Gao Yanmei, Mu Mengyao, Zhu Shiping, Zhang Ning, Lu Minghua. (2023) Ionic liquid-modified UiO-66-NH2 as sorbent of dispersive solid-phase extraction for rapid adsorption and enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 190 (11): (1-11). [PMID:37853180] |
4. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259] |
5. Xian-Xian Ji, Yu-Long Liu, Xin-Yue Chang, Rui-Long Li, Fei Ye, Liu Yang, Ying Fu. (2023) An electrochemical sensor derived from Cu-BTB MOF for the efficient detection of diflubenzuron in food and environmental samples. FOOD CHEMISTRY, 428 (136802). [PMID:37421661] |
6. Juntao Wang, Jiajia Liu, Weihua Liu, Ziwang Liu, Qiuhua Wu, Zhi Wang, Hongyuan Yan. (2023) A phenyl-functionalized nitrogen-rich magnetic hyper crosslinked polymer for magnetic solid-phase extraction of 5-nitroimidazoles residues in water and fish samples. MICROCHEMICAL JOURNAL, 191 (108936). [PMID:] |
7. Mengyao Mu, Shiping Zhu, Yanmei Gao, Ning Zhang, Youmei Wang, Minghua Lu. (2023) Construction of hierarchically porous metal-organic framework HP-UiO-66-30% for sensitive determination of benzoylurea insecticides. TALANTA, 260 (124540). [PMID:37116361] |
8. Honglei Zhao, Ruotong Li, Jiye Hu. (2023) Frequently used pesticides and their metabolites residues in apple and apple juice from markets across China: Occurrence and health risk assessment. LWT-FOOD SCIENCE AND TECHNOLOGY, 178 (114610). [PMID:] |
9. Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang. (2022) Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): (11932). [PMID:36233243] |
10. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Yong Guo, Licheng Wang, Shuai Wang. (2022) Extraction of benzoylurea insecticides from tea leaves based on thermoplastic polyethyleneimine embedded magnetic nanoparticle carbon materials. JOURNAL OF CHROMATOGRAPHY A, 1681 (463476). [PMID:36088774] |
11. Cong Zhang, Wenfeng Hu, Zhuo Yu, Xian Liu, Jing Wang, Tianrong Xin, Zhiwen Zou, Bin Xia. (2022) Characterization of Chitin Synthase A cDNA from Diaphorina citri (Hemiptera: Liviidae) and Its Response to Diflubenzuron. Insects, 13 (8): (728). [PMID:36005353] |
12. Ling Mei, Tiantian Si, Shuai Wang, Jie Zhu, Hao Tang, Xiaojing Liang. (2022) TiO2@MOF-919(Fe–Cu) as a sorbent for the extraction of benzoylurea pesticides from irrigation water and fruit juices. Analytical Methods, 14 (33): (3153-3159). [PMID:35929513] |
13. Min Li, Weihua Liu, Xufeng Meng, Shuofeng Li, Qianqian Wang, Yaxing Guo, Yuanyuan Wu, Lin Hao, Xiumin Yang, Zhi Wang, Chun Wang, Qiuhua Wu. (2022) Facile synthesis of magnetic hypercrosslinked polymer for the magnetic solid-phase extraction of benzoylurea insecticides from honey and apple juice samples. FOOD CHEMISTRY, 395 (133596). [PMID:35792491] |
14. Shuofeng Li, Weihua Liu, Qianqian Wang, Mingming Xu, Yangjuan An, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2022) Constructing magnetic covalent organic framework EB-COF@Fe3O4 for sensitive determination of five benzoylurea insecticides. FOOD CHEMISTRY, 382 (132362). [PMID:35152018] |
15. Weihua Liu, Juntao Wang, Shuangju Song, Lin Hao, Jiajia Liu, Yangjuan An, Yaxing Guo, Qiuhua Wu, Chun Wang, Zhi Wang. (2022) Facile synthesis of uniform spherical covalent organic frameworks for determination of neonicotinoid insecticides. FOOD CHEMISTRY, 367 (130653). [PMID:34343809] |
16. Chaoran Liu, Xiaodong Huang, Zilin Meng, Heng Qian, Xinya Liu, Runhua Lu, Wenfeng Zhou, Haixiang Gao, Donghui Xu. (2020) Study on the adsorption mechanism of benzoylurea insecticides onto modified hyperbranched polysilicon materials. RSC Advances, 10 (48): (28664-28673). [PMID:35520092] |
17. Qianqian Wang, Weihua Liu, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2020) Fabrication of magnetic porous organic framework for effective enrichment and assay of nitroimidazoles in chicken meat. FOOD CHEMISTRY, 332 (127427). [PMID:32619936] |
18. Jiaxuan Fan, Zikai Liu, Jing Li, Wenfeng Zhou, Haixiang Gao, Sanbing Zhang, Runhua Lu. (2020) PEG-modified magnetic Schiff base network-1 materials for the magnetic solid phase extraction of benzoylurea pesticides from environmental water samples. JOURNAL OF CHROMATOGRAPHY A, 1619 (460950). [PMID:32061359] |
19. Duo Huixiao, Li Yijing, Liang Xiaojing, Wang Shuai, Wang Licheng, Guo Yong. (2020) Magnetic 3D hierarchical Ni/NiO@C nanorods derived from metal-organic frameworks for extraction of benzoylurea insecticides prior to HPLC-UV analysis. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31897612] |
20. Huixiao Duo, Xiaofeng Lu, Shuai Wang, Licheng Wang, Yong Guo, Xiaojing Liang. (2019) Synthesis of magnetic metal–organic framework composites, Fe3O4-NH2@MOF-235, for the magnetic solid-phase extraction of benzoylurea insecticides from honey, fruit juice and tap water samples. NEW JOURNAL OF CHEMISTRY, 43 (32): (12563-12569). [PMID:] |
21. Xiaolan Wang, Xufeng Meng, Qiuhua Wu, Chun Wang, Zhi Wang. (2019) Solid phase extraction of carbamate pesticides with porous organic polymer as adsorbent followed by high performance liquid chromatography-diode array detection. JOURNAL OF CHROMATOGRAPHY A, 1600 (9). [PMID:31010634] |
22. Xinyu Liang, Juntao Wang, Qiuhua Wu, Chun Wang, Zhi Wang. (2018) Use of a hypercrosslinked triphenylamine polymer as an efficient adsorbent for the enrichment of phenylurea herbicides. JOURNAL OF CHROMATOGRAPHY A, 1538 (1). [PMID:29397984] |
23. Xinyu Liang, Ruiyang Ma, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2018) β-Cyclodextrin polymer@Fe3O4 based magnetic solid-phase extraction coupled with HPLC for the determination of benzoylurea insecticides from honey, tomato, and environmental water samples. JOURNAL OF SEPARATION SCIENCE, 41 (7): (1539-1547). [PMID:29280564] |
24. Wang Juntao, Jiao Caina, Li Menghua, Wang Xiaolan, Wang Chun, Wu Qiuhua, Wang Zhi. (2018) Porphyrin based porous organic polymer modified with Fe3O4 nanoparticles as an efficient adsorbent for the enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 185 (1): (1-8). [PMID:29594549] |
25. Songqing Li, Lu Hu, Ketao Chen, Haixiang Gao. (2015) Extensible automated dispersive liquid–liquid microextraction. ANALYTICA CHIMICA ACTA, 872 (46). [PMID:25892068] |
26. Jiaheng Zhang, Zhe Liang, Songqing Li, Yubo Li, Bing Peng, Wenfeng Zhou, Haixiang Gao. (2012) In-situ metathesis reaction combined with ultrasound-assisted ionic liquid dispersive liquid–liquid microextraction method for the determination of phenylurea pesticides in water samples. TALANTA, 98 (145). [PMID:22939140] |
27. Hui Yun,Bin Liang,Jiguo Qiu,Long Zhang,Youkang Zhao,Jiandong Jiang,Aijie Wang. (2016-12-15) Functional Characterization of a Novel Amidase Involved in Biotransformation of Triclocarban and its Dehalogenated Congeners in Ochrobactrum sp. TCC-2.. Environmental science & technology, 51 ((1)): (291-300). [PMID:27966913] |