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D114530-250mg

250mg

Available within 4-8 weeks(?)

$206.90

Basic Description

Synonyms	DIFLUBENZURON \| 35367-38-5 \| Difluron \| Dimilin \| Larvakil \| Duphacid \| Astonex \| Dimilin G1 \| Dimilin G4 \| Dimilin ODC-45 \| Dimilin WP-25 \| 1-(4-Chlorophenyl)-3-(2,6-difluorobenzoyl)urea \| Thompson Hayward 6040 \| Thompson-hayward TH6040 \| Philips-duphar PH 60-40 \| N-(4-Chlorophenylca
Specifications & Purity	analytical standard
Biochemical and Physiological Mechanisms	Potent insect growth regulator (IC 50 = 36 nM). Inhibits chitin synthetase and disrupts molting.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Diflubenzuron is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells. An inhibitor of TCDD-induced CYP1a1 expression in HepG2 cells.

Associated Targets(Human)

RXRA Tclin Retinoic acid receptor RXR-alpha (0 Activities)

Discover Target: RXRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor (0 Activities)

Discover Target: AHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (0 Activities)

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

Discover Target: AHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF-CEM (65223 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plutella xylostella (1838 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Spodoptera litura (1708 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Chilo suppressalis (440 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Culex pipiens pallens (759 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mythimna separata (3306 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cacopsylla melanoneura (60 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Daphnia magna (43 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Spilarctia obliqua (13 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adoxophyes orana (52 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(4-chlorophenyl)carbamoyl]-2,6-difluorobenzamide
INCHI	InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)
InChi Key	QQQYTWIFVNKMRW-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F
Isomeric SMILES	C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F
WGK Germany	2
RTECS	YS6200000
PubChem CID	37123
UN Number	3077
Packing Group	III
Molecular Weight	310.68
Beilstein	2162461

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
H2309127	Certificate of Analysis	Aug 15, 2023	D114530
A2314132	Certificate of Analysis	Jan 10, 2023	D114530

Chemical and Physical Properties

Solubility	Soluble in methanol, DMSO, acetone (6.5 mg/ml at 20 °C), and ethanol. Insoluble in water.
Melt Point(°C)	230-232°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H312:Harmful in contact with skin H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P317:Get emergency medical help.
WGK Germany	2
RTECS	YS6200000
Class	9

Alternative Products

Citations of This Product

1. Beibei Zhao, Xinfang Liu, Zheng Cheng, Xu Liu, Xiaoyu Zhang, Xun Feng. (2024) Smartphone-integrated paper-based sensing platform for the visualization and quantitative detection of pymetrozine. FOOD CHEMISTRY, 440 (138269). [PMID:38157705]
2. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Zhimin Yang, Shuai Wang, Yong Guo. (2024) Preparation and extraction property study of corn cob-like magnetic mosaic carbon materials derived from MOF-on-MOF composites. ANALYTICA CHIMICA ACTA, 1287 (342112). [PMID:38182348]
3. Li Dan, Gao Yanmei, Mu Mengyao, Zhu Shiping, Zhang Ning, Lu Minghua. (2023) Ionic liquid-modified UiO-66-NH2 as sorbent of dispersive solid-phase extraction for rapid adsorption and enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 190 (11): (1-11). [PMID:37853180]
4. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259]
5. Xian-Xian Ji, Yu-Long Liu, Xin-Yue Chang, Rui-Long Li, Fei Ye, Liu Yang, Ying Fu. (2023) An electrochemical sensor derived from Cu-BTB MOF for the efficient detection of diflubenzuron in food and environmental samples. FOOD CHEMISTRY, 428 (136802). [PMID:37421661]
6. Juntao Wang, Jiajia Liu, Weihua Liu, Ziwang Liu, Qiuhua Wu, Zhi Wang, Hongyuan Yan. (2023) A phenyl-functionalized nitrogen-rich magnetic hyper crosslinked polymer for magnetic solid-phase extraction of 5-nitroimidazoles residues in water and fish samples. MICROCHEMICAL JOURNAL, 191 (108936). [PMID:]
7. Mengyao Mu, Shiping Zhu, Yanmei Gao, Ning Zhang, Youmei Wang, Minghua Lu. (2023) Construction of hierarchically porous metal-organic framework HP-UiO-66-30% for sensitive determination of benzoylurea insecticides. TALANTA, 260 (124540). [PMID:37116361]
8. Honglei Zhao, Ruotong Li, Jiye Hu. (2023) Frequently used pesticides and their metabolites residues in apple and apple juice from markets across China: Occurrence and health risk assessment. LWT-FOOD SCIENCE AND TECHNOLOGY, 178 (114610). [PMID:]
9. Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang. (2022) Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): (11932). [PMID:36233243]
10. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Yong Guo, Licheng Wang, Shuai Wang. (2022) Extraction of benzoylurea insecticides from tea leaves based on thermoplastic polyethyleneimine embedded magnetic nanoparticle carbon materials. JOURNAL OF CHROMATOGRAPHY A, 1681 (463476). [PMID:36088774]
11. Cong Zhang, Wenfeng Hu, Zhuo Yu, Xian Liu, Jing Wang, Tianrong Xin, Zhiwen Zou, Bin Xia. (2022) Characterization of Chitin Synthase A cDNA from Diaphorina citri (Hemiptera: Liviidae) and Its Response to Diflubenzuron. Insects, 13 (8): (728). [PMID:36005353]
12. Ling Mei, Tiantian Si, Shuai Wang, Jie Zhu, Hao Tang, Xiaojing Liang. (2022) TiO2@MOF-919(Fe–Cu) as a sorbent for the extraction of benzoylurea pesticides from irrigation water and fruit juices. Analytical Methods, 14 (33): (3153-3159). [PMID:35929513]
13. Min Li, Weihua Liu, Xufeng Meng, Shuofeng Li, Qianqian Wang, Yaxing Guo, Yuanyuan Wu, Lin Hao, Xiumin Yang, Zhi Wang, Chun Wang, Qiuhua Wu. (2022) Facile synthesis of magnetic hypercrosslinked polymer for the magnetic solid-phase extraction of benzoylurea insecticides from honey and apple juice samples. FOOD CHEMISTRY, 395 (133596). [PMID:35792491]
14. Shuofeng Li, Weihua Liu, Qianqian Wang, Mingming Xu, Yangjuan An, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2022) Constructing magnetic covalent organic framework EB-COF@Fe3O4 for sensitive determination of five benzoylurea insecticides. FOOD CHEMISTRY, 382 (132362). [PMID:35152018]
15. Hui Yun,Bin Liang,Jiguo Qiu,Long Zhang,Youkang Zhao,Jiandong Jiang,Aijie Wang. (2016-12-15) Functional Characterization of a Novel Amidase Involved in Biotransformation of Triclocarban and its Dehalogenated Congeners in Ochrobactrum sp. TCC-2.. Environmental science & technology, 51 ((1)): (291-300). [PMID:27966913]

References

1. Beibei Zhao, Xinfang Liu, Zheng Cheng, Xu Liu, Xiaoyu Zhang, Xun Feng. (2024) Smartphone-integrated paper-based sensing platform for the visualization and quantitative detection of pymetrozine. FOOD CHEMISTRY, 440 (138269). [PMID:38157705]
2. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Zhimin Yang, Shuai Wang, Yong Guo. (2024) Preparation and extraction property study of corn cob-like magnetic mosaic carbon materials derived from MOF-on-MOF composites. ANALYTICA CHIMICA ACTA, 1287 (342112). [PMID:38182348]
3. Li Dan, Gao Yanmei, Mu Mengyao, Zhu Shiping, Zhang Ning, Lu Minghua. (2023) Ionic liquid-modified UiO-66-NH2 as sorbent of dispersive solid-phase extraction for rapid adsorption and enrichment of benzoylurea insecticides. MICROCHIMICA ACTA, 190 (11): (1-11). [PMID:37853180]
4. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259]
5. Xian-Xian Ji, Yu-Long Liu, Xin-Yue Chang, Rui-Long Li, Fei Ye, Liu Yang, Ying Fu. (2023) An electrochemical sensor derived from Cu-BTB MOF for the efficient detection of diflubenzuron in food and environmental samples. FOOD CHEMISTRY, 428 (136802). [PMID:37421661]
6. Juntao Wang, Jiajia Liu, Weihua Liu, Ziwang Liu, Qiuhua Wu, Zhi Wang, Hongyuan Yan. (2023) A phenyl-functionalized nitrogen-rich magnetic hyper crosslinked polymer for magnetic solid-phase extraction of 5-nitroimidazoles residues in water and fish samples. MICROCHEMICAL JOURNAL, 191 (108936). [PMID:]
7. Mengyao Mu, Shiping Zhu, Yanmei Gao, Ning Zhang, Youmei Wang, Minghua Lu. (2023) Construction of hierarchically porous metal-organic framework HP-UiO-66-30% for sensitive determination of benzoylurea insecticides. TALANTA, 260 (124540). [PMID:37116361]
8. Honglei Zhao, Ruotong Li, Jiye Hu. (2023) Frequently used pesticides and their metabolites residues in apple and apple juice from markets across China: Occurrence and health risk assessment. LWT-FOOD SCIENCE AND TECHNOLOGY, 178 (114610). [PMID:]
9. Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang. (2022) Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): (11932). [PMID:36233243]
10. Xiang Li, Xiaofeng Lu, Xiaojing Liang, Yong Guo, Licheng Wang, Shuai Wang. (2022) Extraction of benzoylurea insecticides from tea leaves based on thermoplastic polyethyleneimine embedded magnetic nanoparticle carbon materials. JOURNAL OF CHROMATOGRAPHY A, 1681 (463476). [PMID:36088774]
11. Cong Zhang, Wenfeng Hu, Zhuo Yu, Xian Liu, Jing Wang, Tianrong Xin, Zhiwen Zou, Bin Xia. (2022) Characterization of Chitin Synthase A cDNA from Diaphorina citri (Hemiptera: Liviidae) and Its Response to Diflubenzuron. Insects, 13 (8): (728). [PMID:36005353]
12. Ling Mei, Tiantian Si, Shuai Wang, Jie Zhu, Hao Tang, Xiaojing Liang. (2022) TiO2@MOF-919(Fe–Cu) as a sorbent for the extraction of benzoylurea pesticides from irrigation water and fruit juices. Analytical Methods, 14 (33): (3153-3159). [PMID:35929513]
13. Min Li, Weihua Liu, Xufeng Meng, Shuofeng Li, Qianqian Wang, Yaxing Guo, Yuanyuan Wu, Lin Hao, Xiumin Yang, Zhi Wang, Chun Wang, Qiuhua Wu. (2022) Facile synthesis of magnetic hypercrosslinked polymer for the magnetic solid-phase extraction of benzoylurea insecticides from honey and apple juice samples. FOOD CHEMISTRY, 395 (133596). [PMID:35792491]
14. Shuofeng Li, Weihua Liu, Qianqian Wang, Mingming Xu, Yangjuan An, Lin Hao, Chun Wang, Qiuhua Wu, Zhi Wang. (2022) Constructing magnetic covalent organic framework EB-COF@Fe3O4 for sensitive determination of five benzoylurea insecticides. FOOD CHEMISTRY, 382 (132362). [PMID:35152018]
15. Hui Yun,Bin Liang,Jiguo Qiu,Long Zhang,Youkang Zhao,Jiandong Jiang,Aijie Wang. (2016-12-15) Functional Characterization of a Novel Amidase Involved in Biotransformation of Triclocarban and its Dehalogenated Congeners in Ochrobactrum sp. TCC-2.. Environmental science & technology, 51 ((1)): (291-300). [PMID:27966913]

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Diflubenzuron - analytical standard, high purity , CAS No.35367-38-5