Selective, non-transportable inhibitor of glutamate transporter EAAT2 (GLT-1) (K i = 23 μM). 130-fold selective over EAAT1 and EAAT3 (K i > 3 mM).
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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2.Naskar K & Stern JE. (2014) A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.. J Physiol, 592 (Pt 13):(2813-27). [PMID:24835172]
3.Uwechue NM et al.. (2012) Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes.. J Physiol, 590 (Pt 10):(2317-31). [PMID:22411007]
4.Potapenko ES et al.. (2012) Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats.. Am J Physiol Regul Integr Comp Physiol, 303 (3):(R291-300). [PMID:22696576]
5.Potapenko ES et al.. (2013) Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons.. J Neurosci, 33 (2):(631-40). [PMID:23303942]
6.Yang Y & Xu-Friedman MA. (2015) Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus.. J Neurophysiol, 113 (10):(3634-45). [PMID:25855696]
7.Armbruster M et al.. (2016) Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex.. J Neurosci, 36 (40):(10404-10415). [PMID:27707974]
8.Budisantoso T et al.. (2012) Mechanisms underlying signal filtering at a multisynapse contact.. J Neurosci, 32 (7):(2357-76). [PMID:22396411]
9.Morioka N et al.. (2014) Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the a7 nicotinic acetylcholine receptor.. Neuroscience, 258 (374-84). [PMID:24300109]
10.Huda R et al.. (2013) pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract.. J Neurophysiol, 110 (2):(368-77). [PMID:23615553]
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