Dihydromyricetin - >97.0%(HPLC), high purity , CAS No.27200-12-0

  • ≥97%(HPLC)
Item Number
D299476
Grouped product items
SKUSizeAvailabilityPrice Qty
D299476-250mg
250mg
In stock
$121.90
D299476-1g
1g
In stock
$375.90
D299476-5g
5g
In stock
$1,688.90
D299476-25g
25g
In stock
$7,598.90
D299476-50g
50g
In stock
$13,677.90
D299476-100g
100g
In stock
$24,620.90

Basic Description

Synonyms(2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (Ampeloptin) | SW219328-1 | (+)-Dihydromyricetin | AKOS022168215 | AS-71702 | Dihydromyricetin | dihydro-myricetin | Dihydromyricetin, anal
Specifications & Purity≥97%(HPLC)
Biochemical and Physiological MechanismsDihydromyricetin possesses anti-inflammatory action.
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2).

Associated Targets(Human)

SYNJ1 Tchem Synaptojanin-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SYNJ2 Tchem Synaptojanin-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APP Tclin Amyloid-beta A4 protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-549 (31254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SYNJ2 Tchem Synaptojanin-2 (76 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SYNJ1 Tchem Synaptojanin-1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488188335
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488188335
IUPAC Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
INCHI InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChi Key KJXSIXMJHKAJOD-LSDHHAIUSA-N
Canonical SMILES C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Isomeric SMILES C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
WGK Germany 3
PubChem CID 161557
Molecular Weight 320.25

Certificates

Certificate of Analysis(COA)

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27 results found

Lot NumberCertificate TypeDateItem
F2228277Certificate of AnalysisApr 02, 2024 D299476
D2428026Certificate of AnalysisJul 29, 2023 D299476
H2407132Certificate of AnalysisJul 29, 2023 D299476
H2316505Certificate of AnalysisJul 29, 2023 D299476
H2316504Certificate of AnalysisJul 29, 2023 D299476
H2316503Certificate of AnalysisJul 29, 2023 D299476
H2316502Certificate of AnalysisJul 29, 2023 D299476
H2316501Certificate of AnalysisJul 29, 2023 D299476
H2120272Certificate of AnalysisMay 12, 2023 D299476
E2308874Certificate of AnalysisApr 23, 2023 D299476
E2308859Certificate of AnalysisApr 23, 2023 D299476
E2308858Certificate of AnalysisApr 23, 2023 D299476
E2308843Certificate of AnalysisApr 23, 2023 D299476
E2308456Certificate of AnalysisApr 23, 2023 D299476
E2308452Certificate of AnalysisApr 23, 2023 D299476
E23081368Certificate of AnalysisApr 23, 2023 D299476
E23081359Certificate of AnalysisApr 23, 2023 D299476
E23081282Certificate of AnalysisApr 23, 2023 D299476
E23081157Certificate of AnalysisApr 23, 2023 D299476
E23081147Certificate of AnalysisApr 23, 2023 D299476
E23081142Certificate of AnalysisApr 23, 2023 D299476
J2021071Certificate of AnalysisAug 05, 2022 D299476
C2306509Certificate of AnalysisJun 04, 2022 D299476
F2228278Certificate of AnalysisJun 04, 2022 D299476
F2228279Certificate of AnalysisJun 04, 2022 D299476
F2228280Certificate of AnalysisJun 04, 2022 D299476
F2228281Certificate of AnalysisJun 04, 2022 D299476

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Chemical and Physical Properties

SolubilityDMSO: ≥5 mg/mL (warmed)
Sensitivitylight sensitive;Hygroscopic
Specific Rotation[α]+15.5 to +17.0 deg(C=0.9, methanol)
Melt Point(°C)248 °C

Safety and Hazards(GHS)

WGK Germany 3
Merck Index 579

Related Documents

Citations of This Product

1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792]
2. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan.  (2023)  Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei).  FISH & SHELLFISH IMMUNOLOGY,  142  (1): (109086).  [PMID:37722436]
3. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li.  (2024)  High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  653  (3): (413).  [PMID:37722170]
4. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu.  (2022)  Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  58  (3): (1120-1129).  [PMID:]
5. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng.  (2023)  Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging.  Food Bioscience,  51  (102294).  [PMID:]
6. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372]
7. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming.  (2021)  Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films.  Food and Bioprocess Technology,  14  (9): (1648-1661).  [PMID:]
8. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259]
9. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277]
10. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646]
11. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355).  [PMID:31438605]
12. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi.  (2019)  Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study.  SAUDI PHARMACEUTICAL JOURNAL,  27  (1000).  [PMID:31997907]
13. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,  107  (25).  [PMID:]
14. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li.  (2018)  Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:]
15. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan.  (2017)  Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology.  MOLECULES,  22  (12): (2250).  [PMID:29258286]
16. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,  32  (296).  [PMID:]
17. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2017)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,  224  (26).  [PMID:28159264]
18. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan.  (2015)  Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,  40  (847).  [PMID:26476886]
19. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang.  (2014)  Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  945-946  (39).  [PMID:24321759]
20. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng.  (2013)  Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin.  JOURNAL OF THE CHINESE CHEMICAL SOCIETY,  60  (8): (1019-1026).  [PMID:]

References

1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792]
2. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan.  (2023)  Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei).  FISH & SHELLFISH IMMUNOLOGY,  142  (1): (109086).  [PMID:37722436]
3. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li.  (2024)  High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  653  (3): (413).  [PMID:37722170]
4. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu.  (2022)  Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  58  (3): (1120-1129).  [PMID:]
5. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng.  (2023)  Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging.  Food Bioscience,  51  (102294).  [PMID:]
6. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372]
7. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming.  (2021)  Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films.  Food and Bioprocess Technology,  14  (9): (1648-1661).  [PMID:]
8. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259]
9. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  239  (118519).  [PMID:32480277]
10. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,  323  (126807).  [PMID:32330646]
11. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu.  (2019)  Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies.  Foods,  (9): (355).  [PMID:31438605]
12. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi.  (2019)  Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study.  SAUDI PHARMACEUTICAL JOURNAL,  27  (1000).  [PMID:31997907]
13. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,  107  (25).  [PMID:]
14. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li.  (2018)  Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:]
15. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan.  (2017)  Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology.  MOLECULES,  22  (12): (2250).  [PMID:29258286]
16. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,  32  (296).  [PMID:]
17. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2017)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,  224  (26).  [PMID:28159264]
18. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan.  (2015)  Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,  40  (847).  [PMID:26476886]
19. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang.  (2014)  Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  945-946  (39).  [PMID:24321759]
20. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng.  (2013)  Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin.  JOURNAL OF THE CHINESE CHEMICAL SOCIETY,  60  (8): (1019-1026).  [PMID:]

Solution Calculators