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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D299476-250mg | 250mg | In stock | $121.90 | |
D299476-1g | 1g | In stock | $375.90 | |
D299476-5g | 5g | In stock | $1,688.90 | |
D299476-25g | 25g | In stock | $7,598.90 | |
D299476-50g | 50g | In stock | $13,677.90 | |
D299476-100g | 100g | In stock | $24,620.90 |
Synonyms | (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (Ampeloptin) | SW219328-1 | (+)-Dihydromyricetin | AKOS022168215 | AS-71702 | Dihydromyricetin | dihydro-myricetin | Dihydromyricetin, anal |
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Specifications & Purity | ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Dihydromyricetin possesses anti-inflammatory action. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Product Description | Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488188335 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488188335 |
IUPAC Name | (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one |
INCHI | InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1 |
InChi Key | KJXSIXMJHKAJOD-LSDHHAIUSA-N |
Canonical SMILES | C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
Isomeric SMILES | C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O |
WGK Germany | 3 |
PubChem CID | 161557 |
Molecular Weight | 320.25 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2228277 | Certificate of Analysis | Apr 02, 2024 | D299476 |
D2428026 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2407132 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2316505 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2316504 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2316503 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2316502 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2316501 | Certificate of Analysis | Jul 29, 2023 | D299476 |
H2120272 | Certificate of Analysis | May 12, 2023 | D299476 |
E2308874 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E2308859 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E2308858 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E2308843 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E2308456 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E2308452 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081368 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081359 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081282 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081157 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081147 | Certificate of Analysis | Apr 23, 2023 | D299476 |
E23081142 | Certificate of Analysis | Apr 23, 2023 | D299476 |
J2021071 | Certificate of Analysis | Aug 05, 2022 | D299476 |
C2306509 | Certificate of Analysis | Jun 04, 2022 | D299476 |
F2228278 | Certificate of Analysis | Jun 04, 2022 | D299476 |
F2228279 | Certificate of Analysis | Jun 04, 2022 | D299476 |
F2228280 | Certificate of Analysis | Jun 04, 2022 | D299476 |
F2228281 | Certificate of Analysis | Jun 04, 2022 | D299476 |
Solubility | DMSO: ≥5 mg/mL (warmed) |
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Sensitivity | light sensitive;Hygroscopic |
Specific Rotation[α] | +15.5 to +17.0 deg(C=0.9, methanol) |
Melt Point(°C) | 248 °C |
WGK Germany | 3 |
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Merck Index | 579 |
Starting at $103.90
Starting at $66.90
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, 20 (17): (101023). [PMID:38144792] |
2. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan. (2023) Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei). FISH & SHELLFISH IMMUNOLOGY, 142 (1): (109086). [PMID:37722436] |
3. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li. (2024) High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 653 (3): (413). [PMID:37722170] |
4. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu. (2022) Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (3): (1120-1129). [PMID:] |
5. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng. (2023) Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging. Food Bioscience, 51 (102294). [PMID:] |
6. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] |
7. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming. (2021) Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films. Food and Bioprocess Technology, 14 (9): (1648-1661). [PMID:] |
8. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang. (2021) Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity. Food & Function, 12 (4): (1580-1589). [PMID:33470259] |
9. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] |
10. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] |
11. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] |
12. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi. (2019) Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study. SAUDI PHARMACEUTICAL JOURNAL, 27 (1000). [PMID:31997907] |
13. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong. (2019) Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity. LWT-FOOD SCIENCE AND TECHNOLOGY, 107 (25). [PMID:] |
14. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li. (2018) Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [PMID:] |
15. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan. (2017) Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology. MOLECULES, 22 (12): (2250). [PMID:29258286] |
16. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, 32 (296). [PMID:] |
17. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] |
18. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan. (2015) Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40 (847). [PMID:26476886] |
19. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang. (2014) Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 945-946 (39). [PMID:24321759] |
20. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng. (2013) Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 60 (8): (1019-1026). [PMID:] |
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, 20 (17): (101023). [PMID:38144792] |
2. Mingxiang Lu, Renzhi Liu, Zhifei Chen, Chen Su, Luqing Pan. (2023) Effects of dietary dihydromyricetin on growth performance, antioxidant capacity, immune response and intestinal microbiota of shrimp (Litopenaeus vannamei). FISH & SHELLFISH IMMUNOLOGY, 142 (1): (109086). [PMID:37722436] |
3. Dongqing Zhang, Wenqi Liu, Ke Ye, Xiaojin Li. (2024) High CO and sulfur tolerant proton exchange membrane fuel cell anodes enabled by “work along both lines” mechanism of 2,6-dihydroxymethyl pyridine molecule blocking layer. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 653 (3): (413). [PMID:37722170] |
4. Shiyu Zhen, Sheng Geng, Hanjun Ma, Benguo Liu. (2022) Interaction of α-lactalbumin with dihydromyricetin and its application in nano-emulsion. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (3): (1120-1129). [PMID:] |
5. Songqi Liu, Zaihan Chen, Huange Zhang, Yuanli Li, Taxipalati Maierhaba, Jianhui An, Zhi Zhou, Lingli Deng. (2023) Comparison of eugenol and dihydromyricetin loaded nanofibers by electro-blowing spinning for active packaging. Food Bioscience, 51 (102294). [PMID:] |
6. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] |
7. Xu Jinfang, Li Xinying, Xu Yaqin, Wang Anqi, Xu Zhilang, Wu Xia, Li Defu, Mu Changdao, Ge Liming. (2021) Dihydromyricetin-Loaded Pickering Emulsions Stabilized by Dialdehyde Cellulose Nanocrystals for Preparation of Antioxidant Gelatin–Based Edible Films. Food and Bioprocess Technology, 14 (9): (1648-1661). [PMID:] |
8. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang. (2021) Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity. Food & Function, 12 (4): (1580-1589). [PMID:33470259] |
9. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] |
10. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] |
11. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] |
12. Hao Liu, Wenmei Zhao, Qi Hu, Ling Zhao, Yumeng Wei, Chao Pi, Yuhan Yang, Xuerong Yang, Hang Yuan, Yuhan Zhang, Kunyan Qu, Xinyu Shi, Yao Huang, Houyin Shi. (2019) Gastric floating sustained-release tablet for dihydromyricetin: Development, characterization, and pharmacokinetics study. SAUDI PHARMACEUTICAL JOURNAL, 27 (1000). [PMID:31997907] |
13. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong. (2019) Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity. LWT-FOOD SCIENCE AND TECHNOLOGY, 107 (25). [PMID:] |
14. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li. (2018) Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [PMID:] |
15. Umair Muhammad, Hedong Lu, Juan Wang, Jinzhi Han, Xiaoyu Zhu, Zhaoxin Lu, Sultana Tayyaba, Yousef I. Hassan. (2017) Optimizing the Maximum Recovery of Dihydromyricetin from Chinese Vine Tea, Ampelopsis grossedentata, Using Response Surface Methodology. MOLECULES, 22 (12): (2250). [PMID:29258286] |
16. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, 32 (296). [PMID:] |
17. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] |
18. Shimei Qi, Xianjuan Kou, Jun Lv, Zhilin Qi, Liang Yan. (2015) Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 40 (847). [PMID:26476886] |
19. Shian Zhong, Yanyue Kong, Ling Zhou, Chengyun Zhou, Xiaona Zhang, Yan Wang. (2014) Efficient conversion of myricetin from Ampelopsis grossedentata extracts and its purification by MIP-SPE. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 945-946 (39). [PMID:24321759] |
20. Fei Wang, Xiang Yu, Haojie Li, Ming Li, Qimin Feng. (2013) Graphene-Nafion Composite Film Modified Electrode for Voltammetric Sensor for Determination of Dihydromyricetin. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 60 (8): (1019-1026). [PMID:] |