H2302676Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | 20a-Progerol | 4-PREGNEN-20ALPHA-OL-3-ONE | NCGC00247054-01 | Opera_ID_1926 | Pregn-4-ene-20alpha-ol-3-one | 20.ALPHA.-HYDROXY-.DELTA.4-PREGNEN-3-ONE | NSC 68630 | (20S)-hydroxypregn-4-en-3-one | 20a-Hydroxypregn-4-en-3-one | 45630A64AC | BRN 2220567 | 20 |
|---|---|
| Specifications & Purity | ≥95% |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Dihydroprogesterone is the main metabolite of Progesterone . Studies shows regulation of estrogen receptor levels in breast cancer by Dihydroprogesterone and other progesterone metabolites. |
Associated Targets(Human)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
CBX1 Tbio Chromobox protein homolog 1 (0 Activities)
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GMNN Tbio Geminin (0 Activities)
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PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor (0 Activities)
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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (0 Activities)
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SMN1 Tchem Survival motor neuron protein (0 Activities)
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PGR Tclin Progesterone receptor (0 Activities)
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MBNL1 Tbio Muscleblind-like protein 1 (0 Activities)
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TARDBP Tchem TAR DNA-binding protein 43 (0 Activities)
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MAPT Tclin Microtubule-associated protein tau (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PGR Tclin Progesterone receptor (8562 Activities)
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PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
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SMN1 Tchem Survival motor neuron protein (34246 Activities)
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GMNN Tbio Geminin (128009 Activities)
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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
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Associated Targets(non-human)
Saccharomyces cerevisiae (19171 Activities)
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Mapt Microtubule-associated protein tau (6 Activities)
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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
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NS1 Nonstructural protein 1 (33327 Activities)
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HSP40, subfamily A, putative (505 Activities)
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SKN7 Transcription factor SKN7 (365 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (8S,9S,10R,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
|---|---|
| INCHI | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 |
| InChi Key | RWBRUCCWZPSBFC-RXRZZTMXSA-N |
| Canonical SMILES | CC(C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O |
| Isomeric SMILES | C[C@@H]([C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O |
| PubChem CID | 8956 |
| Molecular Weight | 316.49 |
Certificates
Certificate of Analysis(COA)
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Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H341:Suspected of causing genetic defects H302:Harmful if swallowed |
| Precautionary Statements | P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |