Dimethyl fumarate - ≥97%, high purity , Kelch-like ECH-associated protein 1 inhibitor, CAS No.624-49-7, Kelch-like ECH-associated protein 1 inhibitor

Item Number
D106459
Grouped product items
SKUSizeAvailabilityPrice Qty
D106459-25g
25g
In stock
$12.90
D106459-100g
100g
In stock
$39.90
D106459-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$109.90

Anti-inflammatory agent

Basic Description

SynonymsCS-0909 | (E/Z)-Dimethyl fumarate | Allomaleic acid dimethyl ester | CCG-213618 | Dimethylfumarate | dimethyl-fumarate | 2-butenedioic acid, (2E)-, dimethyl ester | FO2303MNI2 | DIMETHYL FUMARATE [VANDF] | DTXSID4060787 | STK039379 | BG-12 | But-2-enedioi
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsDimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator. Dimethyl fumarate induces upregulation of antioxidant gene expression. Dimethyl fumarate displays cytoprotective effects in human spinal cord astrocytes, oligodendr
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionKelch-like ECH-associated protein 1 inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EDNRA Tclin Endothelin receptor ET-A (5008 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mucor mucedo (338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BALB/3T3 (534 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton mentagrophytes (4846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name dimethyl (E)-but-2-enedioate
INCHI InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
InChi Key LDCRTTXIJACKKU-ONEGZZNKSA-N
Canonical SMILES COC(=O)C=CC(=O)OC
Isomeric SMILES COC(=O)/C=C/C(=O)OC
WGK Germany 1
RTECS EM6125000
PubChem CID 637568
Molecular Weight 144.13
Beilstein 774590
Reaxy-Rn 774590

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
C1716080Certificate of AnalysisNov 07, 2024 D106459
F2426541Certificate of AnalysisJul 10, 2024 D106459
F2426542Certificate of AnalysisJul 10, 2024 D106459
F2426543Certificate of AnalysisJul 10, 2024 D106459
E2415046Certificate of AnalysisMay 31, 2024 D106459
F2315973Certificate of AnalysisJul 04, 2023 D106459
F2315983Certificate of AnalysisJul 04, 2023 D106459
I1530028Certificate of AnalysisJun 05, 2023 D106459

Chemical and Physical Properties

SolubilityInsoluble in water; Soluble in Chloroform,Acetone
Boil Point(°C)193°C
Melt Point(°C)103—104°C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H411:Toxic to aquatic life with long lasting effects

H317:May cause an allergic skin reaction

H312:Harmful in contact with skin

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 1
RTECS EM6125000
Reaxy-Rn 774590
Merck Index 4287

Related Documents

Citations of This Product

1. Caihong Wang, Yong Liu, Fengshen Han, Yongzhe Han, Tianyu Liu, Haitao Ren, Xu Han.  (2023)  Nitrogen-doped carbocatalyst activated persulfate (PS) for oxidation polymerization of bisphenol A (BPA): importance of nonradical activation of PS.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,  25  (19): (13716-13727).  [PMID:37158256] [10.1039/D3CP00659J]
2. Shao-Qi Zhi, Jun-Yuan Zhang, Song-Hai Wu, Wen-Shuang Zhu, Yu-Dong Shan, Yong Liu, Xu Han.  (2023)  Oxidative Desulfurization of Benzothiophene by Persulfate and Cu-Loaded g-C3 N4 via the Polymerization Pathway.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  62  (9): (3909–3920).  [PMID:] [10.1021/acs.iecr.2c04484]
3. Xin‐Lin Zhang, Ting‐Yu Wang, Zheng Chen, Hong‐Wei Wang, Yong Yin, Lian Wang, Yong Wang, Biao Xu, Wei Xu.  (2022)  HMGB1‐Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice.  Journal of the American Heart Association,      [PMID:35156391] [10.1161/JAHA.121.023800]
4. Tian-Yu Liu, Cong Wang, Yong-Zhe Han, Chang Bai, Hai-Tao Ren, Yong Liu, Xu Han.  (2022)  Oxidative polymerization of bisphenol A (BPA) via H-abstraction by Bi2.15WO6 and persulfate: Importance of the surface complexes.  CHEMICAL ENGINEERING JOURNAL,  435  (134816).  [PMID:] [10.1016/j.cej.2022.134816]
5. Chang Bai, Yong Liu, Cong Wang, Xiao-Cong Zhang, Jia-Xuan Wu, Hai-Tao Ren, Xu Han.  (2021)  Conversion of aniline contaminant to valuable polyaniline polymers from wastewater under alkaline conditions.  Molecular Catalysis,  503  (111430).  [PMID:] [10.1016/j.mcat.2021.111430]
6. Xiao-Cong Zhang, Song-Hai Wu, Shao-Yi Jia, Cong Wang, Shi-Wei Sun, Xiang-Ming Wang, Zi-He Meng, Yi-Ying Lin, Yong Liu, Hai-Tao Ren, Xu Han.  (2020)  Turning thiophene contaminant into polymers from wastewater by persulfate and CuO.  CHEMICAL ENGINEERING JOURNAL,  397  (125351).  [PMID:] [10.1016/j.cej.2020.125351]

References

1. Take-Aki Mitsudo,Yasuyuki Ura,Teruyuki Kondo.  (2006-06-30)  Chemistry of Ru(eta6-1,3,5-cyclooctatriene)(eta2-dimethyl fumarate)2..  Chemical record (New York, N.Y.),  ((3)): (107-116).  [PMID:16807912]
2. Frieder Kees.  (2013-05-24)  Dimethyl fumarate : a Janus-faced substance?.  Expert opinion on pharmacotherapy,  14  ((11)): (1559-1567).  [PMID:23697607]
3. Sergey Kalinin,Paul E Polak,Shao Xia Lin,David Braun,Marina Guizzetti,Xiaolu Zhang,Israel Rubinstein,Douglas L Feinstein.  (2013-08-07)  Dimethyl fumarate regulates histone deacetylase expression in astrocytes..  Journal of neuroimmunology,  263  ((1-2)): (13-19).  [PMID:23916696]
4. Masanobu Tsubaki,Makiko Komai,Tatsuki Itoh,Motohiro Imano,Kotaro Sakamoto,Hirotaka Shimaoka,Naoki Ogawa,Kenji Mashimo,Daichiro Fujiwara,Tomoya Takeda,Junji Mukai,Katsuhiko Sakaguchi,Takao Satou,Shozo Nishida.  (2013-08-13)  Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs..  European journal of cancer (Oxford, England : 1990),  49  ((17)): (3708-3717).  [PMID:23932230]
5. Alexander J Gill,Dennis L Kolson.  (2013-08-27)  Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy..  Critical reviews in immunology,  33  ((4)): (307-359).  [PMID:23971529]
6. Ralf A Linker,Ralf Gold.  (2013-09-26)  Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects..  Current neurology and neuroscience reports,  13  ((11)): (394-394).  [PMID:24061646]
7. Karelle Bénardais,Refik Pul,Vikramjeet Singh,Thomas Skripuletz,De-Hyung Lee,Ralf A Linker,Viktoria Gudi,Martin Stangel.  (2013-10-01)  Effects of fumaric acid esters on blood-brain barrier tight junction proteins..  Neuroscience letters,  555  (165-170).  [PMID:24076006]
8. Christiane Reick,Gisa Ellrichmann,Jan Thöne,Robert H Scannevin,Carsten Saft,Ralf A Linker,Ralf Gold.  (2014-04-16)  Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation..  Experimental neurology,  257  (50-56).  [PMID:24731948]
9. Marco Passarello,Sergio Abbate,Giovanna Longhi,Susan Lepri,Renzo Ruzziconi,Valentin Paul Nicu.  (2014-05-21)  Importance of C*-H based modes and large amplitude motion effects in vibrational circular dichroism spectra: the case of the chiral adduct of dimethyl fumarate and anthracene..  The journal of physical chemistry. A,  118  ((24)): (4339-4350).  [PMID:24840313]
10. Ju-Yi Hsieh,Jyung-Hurng Liu,Pai-Chun Yang,Chi-Li Lin,Guang-Yaw Liu,Hui-Chih Hung.  (2014-06-10)  Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme..  PloS one,  ((6)): (e98385-e98385).  [PMID:24911153]
11. Yasuhiro Nakagami,Kayoko Masuda,Emiko Hatano,Tatsuya Inoue,Takuya Matsuyama,Mayumi Iizuka,Yasunori Ono,Takashi Ohnuki,Yoko Murakami,Masaru Iwasaki,Kazuhiro Yoshida,Yuji Kasuya,Satoshi Komoriya.  (2014-11-05)  Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits..  British journal of pharmacology,  172  ((5)): (1237-1249).  [PMID:25363737]
12. Paola Bocchini,Francesca Pinelli,Romina Pozzi,Federica Ghetti,Guido C Galletti.  (2015-05-06)  Quantitative determination of dimethyl fumarate in silica gel by solid-phase microextraction/gas chromatography/mass spectrometry and ultrasound-assisted extraction/gas chromatography/mass spectrometry..  Environmental monitoring and assessment,  187  ((6)): (320-320).  [PMID:25939646]
13. Qin Wang,Sergei Chuikov,Sophina Taitano,Qi Wu,Arjun Rastogi,Samuel J Tuck,Joseph M Corey,Steven K Lundy,Yang Mao-Draayer.  (2015-06-20)  Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway..  International journal of molecular sciences,  16  ((6)): (13885-13907).  [PMID:26090715]
14. Thomas J Farmer,Rachael L Castle,James H Clark,Duncan J Macquarrie.  (2015-07-07)  Synthesis of Unsaturated Polyester Resins from Various Bio-Derived Platform Molecules..  International journal of molecular sciences,  16  ((7)): (14912-14932).  [PMID:26147423]
15. Po Yen Lin,Hung Lin Lee,Chih Wei Chen,Tu Lee.  (2015-09-30)  Effects of baffle configuration and tank size on spherical agglomerates of dimethyl fumarate in a common stirred tank..  International journal of pharmaceutics,  495  ((2)): (886-894).  [PMID:26417848]
16. Giovanna Casili,Michela Campolo,Irene Paterniti,Marika Lanza,Alessia Filippone,Salvatore Cuzzocrea,Emanuela Esposito.  (2018-01-25)  Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury..  Journal of neurotrauma,  35  ((13)): (1437-1451).  [PMID:29361881]
17. Parker L Sulkowski,Ranjini K Sundaram,Sebastian Oeck,Christopher D Corso,Yanfeng Liu,Seth Noorbakhsh,Monica Niger,Marta Boeke,Daiki Ueno,Aravind Nambiar Kalathil,Xun Bao,Jing Li,Brian Shuch,Ranjit S Bindra,Peter M Glazer.  (2018-07-18)  Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair..  Nature genetics,  50  ((8)): (1086-1092).  [PMID:30013182]
18. Minghui Gao,Junmei Yi,Jiajun Zhu,Alexander M Minikes,Prashant Monian,Craig B Thompson,Xuejun Jiang.  (2018-12-26)  Role of Mitochondria in Ferroptosis..  Molecular cell,  73  ((2)): (354-363).  [PMID:30581146]
19. Jianning Zhu,Qing Wang,Cong Li,Yuchao Lu,Henglong Hu,Baolong Qin,Yang Xun,Yunpeng Zhu,Yue Wu,Jiaqiao Zhang,Shaogang Wang.  (2019-01-02)  Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate..  Free radical biology & medicine,  134  (9-22).  [PMID:30599261]
20. Rhushikesh A Kulkarni,Daniel W Bak,Darmood Wei,Sarah E Bergholtz,Chloe A Briney,Jonathan H Shrimp,Aktan Alpsoy,Abigail L Thorpe,Arissa E Bavari,Daniel R Crooks,Michaella Levy,Laurence Florens,Michael P Washburn,Norma Frizzell,Emily C Dykhuizen,Eranthie Weerapana,W Marston Linehan,Jordan L Meier.  (2019-02-06)  A chemoproteomic portrait of the oncometabolite fumarate..  Nature chemical biology,  15  ((4)): (391-400).  [PMID:30718813]
21. Balyn W Zaro,Ekaterina V Vinogradova,Daniel C Lazar,Megan M Blewett,Radu M Suciu,Junichiro Takaya,Sean Studer,Juan Carlos de la Torre,Jean-Laurent Casanova,Benjamin F Cravatt,John R Teijaro.  (2019-03-20)  Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex..  Journal of immunology (Baltimore, Md. : 1950),  202  ((9)): (2737-2746).  [PMID:30885957]
22. Rikke Illum Høgh,Alec Droujinine,Sofie Hedlund Møller,Stine Dam Jepsen,Maiken Mellergaard,Lars Andresen,Søren Skov.  (2020-03-08)  Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity..  Journal of immunology (Baltimore, Md. : 1950),  204  ((7)): (1746-1759).  [PMID:32144161]
23. Ekaterina V Vinogradova,Xiaoyu Zhang,David Remillard,Daniel C Lazar,Radu M Suciu,Yujia Wang,Giulia Bianco,Yu Yamashita,Vincent M Crowley,Michael A Schafroth,Minoru Yokoyama,David B Konrad,Kenneth M Lum,Gabriel M Simon,Esther K Kemper,Michael R Lazear,Sifei Yin,Megan M Blewett,Melissa M Dix,Nhan Nguyen,Maxim N Shokhirev,Emily N Chin,Luke L Lairson,Bruno Melillo,Stuart L Schreiber,Stefano Forli,John R Teijaro,Benjamin F Cravatt.  (2020-07-31)  An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells..  Cell,  182  ((4)): (1009-1026).  [PMID:32730809]
24. Ye Zhang,Shuang Zhao,Ying Fu,Lu Yan,Yilu Feng,Yaqi Chen,Yijia Wu,Yalan Deng,Guiying Zhang,Zhuchu Chen,Yongheng Chen,Ting Liu.  (2020-08-20)  Computational repositioning of dimethyl fumarate for treating alcoholic liver disease..  Cell death & disease,  11  ((8)): (641-641).  [PMID:32811823]
25. David Van Ly,Nicholas J C King,Lyn M Moir,Janette K Burgess,Judith L Black,Brian G Oliver.  (2011-11-29)  Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts..  Journal of allergy,  2011  (457169-457169).  [PMID:22121382]
26. Chung-Yang Huang,Abigail G Doyle.  (2012-03-15)  Nickel-catalyzed Negishi alkylations of styrenyl aziridines..  Journal of the American Chemical Society,  134  ((23)): (9541-9544).  [PMID:22414150]
27. Markus Meissner,Eva Maria Valesky,Stefan Kippenberger,Roland Kaufmann.  (2012-08-18)  Dimethyl fumarate - only an anti-psoriatic medication?.  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,  10  ((11)): (793-801).  [PMID:22897153]
28. Martin Stangel,Ralf A Linker.  (2013-08-10)  Dimethyl fumarate (BG-12) for the treatment of multiple sclerosis..  Expert review of clinical pharmacology,  ((4)): (355-362).  [PMID:23927662]
29. R Gold.  (2013-11-01)  [Immunomodulation with oral dosage forms and their mechanisms of action]..  Drug research,  63 Suppl 1  (S9-S9).  [PMID:24242042]
30. Athanasios Tsianakas,Sabine Herzog,Aysche Landmann,Nikolaos Patsinakidis,Ana María Perusquía Ortiz,Gisela Bonsmann,Thomas A Luger,Annegret Kuhn.  (2014-06-21)  Successful treatment of discoid lupus erythematosus with fumaric acid esters..  Journal of the American Academy of Dermatology,  71  ((1)): (e15-e17).  [PMID:24947703]
31. Michael D Carrithers.  (2014-09-15)  Update on disease-modifying treatments for multiple sclerosis..  Clinical therapeutics,  36  ((12)): (1938-1945).  [PMID:25218310]
32. Xinke Zhang,Joel W Hay,Xiaoli Niu.  (2014-10-20)  Cost effectiveness of fingolimod, teriflunomide, dimethyl fumarate and intramuscular interferon-β1a in relapsing-remitting multiple sclerosis..  CNS drugs,  29  ((1)): (71-81).  [PMID:25326785]
33. X Y Chen,R Li,Z Y Geng.  (2015-10-11)  Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens..  Poultry science,  94  ((11)): (2597-2603).  [PMID:26453599]
34. Lei Liu,Mary K Vollmer,Abdullah S Ahmad,Victoria M Fernandez,Hocheol Kim,Sylvain Doré.  (2018-11-21)  Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism..  Free radical biology & medicine,  131  (98-114).  [PMID:30458277]
35. M Galán-Ganga,R Del Río,N Jiménez-Moreno,M Díaz-Guerra,I Lastres-Becker.  (2019-08-07)  Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells..  Cellular and molecular neurobiology,  40  ((1)): (167-177).  [PMID:31385133]
36. Christina Lückel,Felix Picard,Hartmann Raifer,Lucia Campos Carrascosa,Anna Guralnik,Yajuan Zhang,Matthias Klein,Stefan Bittner,Falk Steffen,Sonja Moos,Federico Marini,Renee Gloury,Florian C Kurschus,Ying-Yin Chao,Wilhelm Bertrams,Veronika Sexl,Bernd Schmeck,Lynn Bonetti,Melanie Grusdat,Michael Lohoff,Christina E Zielinski,Frauke Zipp,Axel Kallies,Dirk Brenner,Michael Berger,Tobias Bopp,Björn Tackenberg,Magdalena Huber.  (2019-12-18)  IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis..  Nature communications,  10  ((1)): (5722-5722).  [PMID:31844089]
37. Yanwen Chen,John W Evankovich,Travis B Lear,Ferhan Tuncer,Jason R Kennerdell,Daniel P Camarco,Morgan S Shishido,Yuan Liu,Bill B Chen.  (2020-03-17)  A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis..  Redox biology,  32  (101485-101485).  [PMID:32171724]
38. David Olagnier,Ensieh Farahani,Jacob Thyrsted,Julia Blay-Cadanet,Angela Herengt,Manja Idorn,Alon Hait,Bruno Hernaez,Alice Knudsen,Marie Beck Iversen,Mirjam Schilling,Sofie E Jørgensen,Michelle Thomsen,Line S Reinert,Michael Lappe,Huy-Dung Hoang,Victoria H Gilchrist,Anne Louise Hansen,Rasmus Ottosen,Camilla G Nielsen,Charlotte Møller,Demi van der Horst,Suraj Peri,Siddharth Balachandran,Jinrong Huang,Martin Jakobsen,Esben B Svenningsen,Thomas B Poulsen,Lydia Bartsch,Anne L Thielke,Yonglun Luo,Tommy Alain,Jan Rehwinkel,Antonio Alcamí,John Hiscott,Trine H Mogensen,Søren R Paludan,Christian K Holm.  (2020-10-04)  SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate..  Nature communications,  11  ((1)): (4938-4938).  [PMID:33009401]
39. Adrián Povo-Retana,Marina Mojena,Adrian B Stremtan,Victoria B Fernández-García,Ana Gómez-Sáez,Cristina Nuevo-Tapioles,José M Molina-Guijarro,José Avendaño-Ortiz,José M Cuezva,Eduardo López-Collazo,Juan F Martínez-Leal,Lisardo Boscá.  (2020-10-24)  Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights..  Cancers,  12  ((10)):   [PMID:33092171]
40. Caihong Wang, Yong Liu, Fengshen Han, Yongzhe Han, Tianyu Liu, Haitao Ren, Xu Han.  (2023)  Nitrogen-doped carbocatalyst activated persulfate (PS) for oxidation polymerization of bisphenol A (BPA): importance of nonradical activation of PS.  PHYSICAL CHEMISTRY CHEMICAL PHYSICS,  25  (19): (13716-13727).  [PMID:37158256] [10.1039/D3CP00659J]
41. Shao-Qi Zhi, Jun-Yuan Zhang, Song-Hai Wu, Wen-Shuang Zhu, Yu-Dong Shan, Yong Liu, Xu Han.  (2023)  Oxidative Desulfurization of Benzothiophene by Persulfate and Cu-Loaded g-C3 N4 via the Polymerization Pathway.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,  62  (9): (3909–3920).  [PMID:] [10.1021/acs.iecr.2c04484]
42. Xin‐Lin Zhang, Ting‐Yu Wang, Zheng Chen, Hong‐Wei Wang, Yong Yin, Lian Wang, Yong Wang, Biao Xu, Wei Xu.  (2022)  HMGB1‐Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice.  Journal of the American Heart Association,      [PMID:35156391] [10.1161/JAHA.121.023800]
43. Tian-Yu Liu, Cong Wang, Yong-Zhe Han, Chang Bai, Hai-Tao Ren, Yong Liu, Xu Han.  (2022)  Oxidative polymerization of bisphenol A (BPA) via H-abstraction by Bi2.15WO6 and persulfate: Importance of the surface complexes.  CHEMICAL ENGINEERING JOURNAL,  435  (134816).  [PMID:] [10.1016/j.cej.2022.134816]
44. Chang Bai, Yong Liu, Cong Wang, Xiao-Cong Zhang, Jia-Xuan Wu, Hai-Tao Ren, Xu Han.  (2021)  Conversion of aniline contaminant to valuable polyaniline polymers from wastewater under alkaline conditions.  Molecular Catalysis,  503  (111430).  [PMID:] [10.1016/j.mcat.2021.111430]
45. Xiao-Cong Zhang, Song-Hai Wu, Shao-Yi Jia, Cong Wang, Shi-Wei Sun, Xiang-Ming Wang, Zi-He Meng, Yi-Ying Lin, Yong Liu, Hai-Tao Ren, Xu Han.  (2020)  Turning thiophene contaminant into polymers from wastewater by persulfate and CuO.  CHEMICAL ENGINEERING JOURNAL,  397  (125351).  [PMID:] [10.1016/j.cej.2020.125351]

Solution Calculators