Antiproliferative and apoptotic agent. Increases caspase-3 and Bax expression. Decreases Bcl-2 expression. Shows membrane disruptive and antifungal effects in vivo.
Shipped In
Normal
Grade
analytical standard, Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of CXCR3
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human)
CXCR3TchemC-X-C chemokine receptor type 3 (1 Activities)
1.Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. (2021) Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. AUTOIMMUNITY, 54 (1):(51-59). [PMID:33274645][10.1080/08916934.2020.1855428]
2.Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu. (2019) Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. JOURNAL OF CELLULAR PHYSIOLOGY, 235 (3):(2911-2924). [PMID:31535374][10.1002/jcp.29197]
1.Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. (2021) Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. AUTOIMMUNITY, 54 (1):(51-59). [PMID:33274645][10.1080/08916934.2020.1855428]
2.Qiuyue Ding, Wenda Zhang, Cheng Cheng, Fengbo Mo, Lei Chen, Guangfu Peng, Xianyi Cai, Jinglong Wang, Shuhua Yang, Xianzhe Liu. (2019) Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo. JOURNAL OF CELLULAR PHYSIOLOGY, 235 (3):(2911-2924). [PMID:31535374][10.1002/jcp.29197]
A1915131