Potent NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase inhibitor (IC 50 = 30 nM, NO production). Suppresses light-dependent induction of clock and DNA repair genes. Inhibits platelet aggregation in vivo.Diphenyliodonium (DPI) can affe
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of GPR3
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
1.Denan Mu, Jinfeng Xing. (2023) The preparation of double network hydrogel with high mechanical properties by photopolymerization under the green LED irradiation and enhancement of wet adhesion by tannic acid. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 671 (131656). [PMID:][10.1016/j.colsurfa.2023.131656]
2.Shujie Liu, Zhen Wang, Jinfeng Xing. (2022) A tunable multifunctional hydrogel with balanced adhesion, toughness and self-healing ability prepared by photopolymerization under green LED irradiation for wound dressing. EUROPEAN POLYMER JOURNAL, 168 (111119). [PMID:][10.1016/j.eurpolymj.2022.111119]
3.Shuang Guo, Yue Ma, Hao Liang, Xiaoyan Zhao, Dan Wang. (2021) The effect of diphenyliodonium iodide treatment on bisdemethoxycurcumin accumulation in fresh-cut yam. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (1):(566-575). [PMID:][10.1111/ijfs.15452]
References
1.Chen MS et al.. (2020) Lipofundin Mediates the Major Inhibition of Intravenous Propofol in IL-1ß Secretion and Phagocytosis of Staphylococcus aureus-Infected Macrophages.. Lipids, 55 (45-52). [PMID:31838756]
2.Chen MS et al.. (2019) Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl.. Life Sci, 221 (178-186). [PMID:30771312]
3.Chen MS et al.. (2018) Propofol specifically suppresses IL-1ß secretion but increases bacterial survival in Staphylococcus aureus-infected RAW264.7 cells.. Mol Cell Biochem, 449 (1-2):(117-125). [PMID:29667111]
4.Chen MS et al.. (2021) Three Lipid Emulsions Reduce Staphylococcus aureus-Stimulated Phagocytosis in Mouse RAW264.7 Cells.. Microorganisms, 9 (12):[PMID:34946079]
5.Denan Mu, Jinfeng Xing. (2023) The preparation of double network hydrogel with high mechanical properties by photopolymerization under the green LED irradiation and enhancement of wet adhesion by tannic acid. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 671 (131656). [PMID:][10.1016/j.colsurfa.2023.131656]
6.Shujie Liu, Zhen Wang, Jinfeng Xing. (2022) A tunable multifunctional hydrogel with balanced adhesion, toughness and self-healing ability prepared by photopolymerization under green LED irradiation for wound dressing. EUROPEAN POLYMER JOURNAL, 168 (111119). [PMID:][10.1016/j.eurpolymj.2022.111119]
7.Shuang Guo, Yue Ma, Hao Liang, Xiaoyan Zhao, Dan Wang. (2021) The effect of diphenyliodonium iodide treatment on bisdemethoxycurcumin accumulation in fresh-cut yam. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (1):(566-575). [PMID:][10.1111/ijfs.15452]
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E2429398