Dirlotapide - ≥99.0%, high purity , CAS No.481658-94-0

Item Number

D651112

• Synonyms: Dirlotapide [USAN:INN] | Slentrol [veterinary] (TN) | Q5280905 | BDBM50204367 | D03867 | DB11399 | dirlotapida | dirlotapidum | 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide | 6-carboxy-5'-uridy
• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.

In Vivo

Dogs receiving 0.3 mg dirlotapide/kg once daily have a small but significant (P=0.018) decrease (6.16 ± 2.22%, mean ± SD) in crude fat digestibility compared with the placebo-treated food-restricted dogs, but no difference in crude protein, dry matter, or energy digestibility is observed. Dirlotapide effectively reduces appetite and energy intake without affecting nutrient digestibility, except for a minimal decrease in fat digestibility . Dirlotapide (0.5 mg/kg) results in a high rate of weight loss (3.3% weekly) and anorexia, emesis, and loose stools for some dogs. Dirlotapide produces weight loss by both reducing appetite (about 90% of the weight loss activity) and by increasing fecal fat excretion (about 10% of the weight loss activity). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Dirlotapide in the commercial formulation of a 5-mg/mL oil solution, is administered at an initial rate of 0.5 mg/kg adjusted individually based on the weight loss change in the previous 2 weeks. Dogs assigned to placebo receive the oil vehicle (identical in appearance to the dirlotapide solution) at a rate of 0.1 mL/kg and 0.075 mL/kg during the weight loss and weight management phases, respectively. The dose volume is administered directly into the dog's mouth with a dosing syringe approximately 30 min before feeding. aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid