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disprocynium24 , CAS No.D609915, Inhibitor of Organic cation transporter 3
Basic Description
| Synonyms | 1,1'-Diisopropyl-2,4'-cyanine |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of Organic cation transporter 3 |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | (2E)-1-propan-2-yl-2-[(1-propan-2-ylquinolin-1-ium-4-yl)methylidene]quinoline |
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| INCHI | InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 |
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| InChi Key | TYFOKKOWQOKKCH-UHFFFAOYSA-N |
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| Canonical SMILES | CC([n+]1ccc(c2c1cccc2)/C=c\1/ccc2c(n1C(C)C)cccc2)C |
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| Isomeric SMILES | CC(C)N1/C(=C\C2=CC=[N+](C3=CC=CC=C23)C(C)C)/C=CC4=CC=CC=C41 |
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| PubChem CID | 10004133 |
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References
| 1. Gründemann D, Schechinger B, Rappold GA, Schömig E. (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.. Nat Neurosci, 1 (5): (349-51). [PMID:10196521] |
| 2. Graefe KH, Friedgen B, Wölfel R, Bossle F, Russ H, Schömig E. (1997) 1,1'-Diisopropyl-2,4'-cyanine (disprocynium24), a potent uptake2 blocker, inhibits the renal excretion of catecholamines.. Naunyn Schmiedebergs Arch Pharmacol, 356 (1): (115-25). [PMID:9228198] |
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