Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	DKFZ-251 is a potent inhibitor of kallikrein-related peptidase 6 with on-target cellular activity. DKFZ-251 demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of kallikrein related peptidase 6

Associated Targets(Human)

KLK6 Tchem Kallikrein-6 (2 Activities)

Discover Target: KLK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK7 Tchem Kallikrein 7 (657 Activities)

Discover Target: KLK7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK3 Tclin Prostate specific antigen (150 Activities)

Discover Target: KLK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK8 Tchem Kallikrein 8 (46 Activities)

Discover Target: KLK8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK13 Tchem Kallikrein 13 (14 Activities)

Discover Target: KLK13

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK14 Tchem Kallikrein 14 (94 Activities)

Discover Target: KLK14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK4 Tchem Kallikrein 4 (51 Activities)

Discover Target: KLK4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK5 Tchem Kallikrein 5 (307 Activities)

Discover Target: KLK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KLK6 Tchem Kallikrein 6 (143 Activities)

Discover Target: KLK6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAL-27 (814 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Trypsin (394 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	[2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methyl-1H-indol-3-yl)acetate
INCHI	InChI=1S/C24H24N4O3/c1-15-20(19-11-7-8-12-21(19)25-15)13-23(30)31-14-22(29)26-24-16(2)27-28(17(24)3)18-9-5-4-6-10-18/h4-12,25H,13-14H2,1-3H3,(H,26,29)
InChi Key	OWHVQGGLXPNNBI-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1c(C)nn(c1C)c1ccccc1)COC(=O)Cc1c(C)[nH]c2c1cccc2
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)CC(=O)OCC(=O)NC3=C(N(N=C3C)C4=CC=CC=C4)C
Molecular Weight	416.47

Database links

PubChem CID	38335241
CAS Registry No.	2222059-70-1

Certificates

Certificate of Analysis(COA)

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. An Zhengfang, Gu Xiaoxu, Liu Yue, Ge Jingyan, Zhu Qing. (2017) Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013. CATALYSIS LETTERS, 147 (4): (837-844). [PMID:] [10.1007/s10562-017-1999-3]

References

1. De Vita E, Schüler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Heßling B, Hamon V, Papo N et al.. (2018) Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.. J Med Chem, 61 (19): (8859-8874). [PMID:30212625] [10.1021/op500134e]
2. An Zhengfang, Gu Xiaoxu, Liu Yue, Ge Jingyan, Zhu Qing. (2017) Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013. CATALYSIS LETTERS, 147 (4): (837-844). [PMID:] [10.1007/s10562-017-1999-3]

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SKU	Size	Availability	Price	Qty
D609919-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609919-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

DKFZ‐251 , CAS No.2222059-70-1, Inhibitor of kallikrein related peptidase 6