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DKFZ‐251 , CAS No.2222059-70-1, Inhibitor of kallikrein related peptidase 6

Moligand™

CAS#: 2222059-70-1
PubChem CID: 38335241

Item Number

D609919

Grouped product items
SKU	Size	Availability	Price	Qty
D609919-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609919-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Synonyms

compound 11

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of kallikrein related peptidase 6

Associated Targets

PRSS1 Tclin Trypsin-1 0 Activities

Discover Target: PRSS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK7 Tchem Kallikrein-7 0 Activities

Discover Target: KLK7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK13 Tchem Kallikrein-13 0 Activities

Discover Target: KLK13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK3 Tclin Prostate-specific antigen 0 Activities

Discover Target: KLK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK5 Tchem Kallikrein-5 0 Activities

Discover Target: KLK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK6 Tchem Kallikrein-6 2 Activities

Discover Target: KLK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK8 Tchem Kallikrein-8 0 Activities

Discover Target: KLK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK14 Tchem Kallikrein-14 0 Activities

Discover Target: KLK14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KLK4 Tchem Kallikrein-4 0 Activities

Discover Target: KLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methyl-1H-indol-3-yl)acetate
INCHI	InChI=1S/C24H24N4O3/c1-15-20(19-11-7-8-12-21(19)25-15)13-23(30)31-14-22(29)26-24-16(2)27-28(17(24)3)18-9-5-4-6-10-18/h4-12,25H,13-14H2,1-3H3,(H,26,29)
InChi Key	OWHVQGGLXPNNBI-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1c(C)nn(c1C)c1ccccc1)COC(=O)Cc1c(C)[nH]c2c1cccc2
Isomeric SMILES	CC1=C(C2=CC=CC=C2N1)CC(=O)OCC(=O)NC3=C(N(N=C3C)C4=CC=CC=C4)C
PubChem CID	38335241

PubChem CID

38335241

CAS Registry No.

2222059-70-1

References

1. De Vita E, Schüler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Heßling B, Hamon V, Papo N et al.. (2018) Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.. J Med Chem, 61 (19): (8859-8874). [PMID:30212625]

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