DL-Adrenaline (Racepinephrine) - 98%, high purity , CAS No.329-65-7, Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor;Agonist of β 1-adrenoceptor;Agonist of β 3-adrenoceptor

Item Number
D274858
Grouped product items
SKUSizeAvailabilityPrice Qty
D274858-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$90.90

Non-selective adrenoceptor agonist

Basic Description

Synonyms(+/-)-Epinephrine;DL-Adrenaline;(+/-)-Adrenaline | Racepinefrina | Racemic adrenaline | 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- | CCRIS 8140 | Epinephrine, Racemic | Epirenamine | Racepinefrinum [INN-Latin] | BRN-2938799 | FT-0625455 | MLS001
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsNon-selective adrenoceptor agonist. Induces lipolysis and systemic muscle contraction. Shows systemic vasoconstrictive, bronchodilatory, positive chronotropic and gastrointestinal relaxant effects in vivo.
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor;Agonist of β 1-adrenoceptor;Agonist of β 3-adrenoceptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

ADRA2B Tclin Alpha-2B adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2C Tclin Alpha-2C adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB3 Tclin Beta-3 adrenergic receptor (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB1 Tclin Beta-1 adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
INCHI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3
InChi Key UCTWMZQNUQWSLP-UHFFFAOYSA-N
Canonical SMILES CNCC(C1=CC(=C(C=C1)O)O)O
Isomeric SMILES CNCC(C1=CC(=C(C=C1)O)O)O
PubChem CID 838
UN Number 2811
Packing Group I
Molecular Weight 183.2

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDateItem
K2105687Certificate of AnalysisSep 09, 2022 D274858

Chemical and Physical Properties

SolubilitySoluble in DMSO
Sensitivitylight sensitive
Melt Point(°C)197°

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H311:Toxic in contact with skin

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

Class 6.1

Related Documents

Citations of This Product

1. Xin Song, Jiaqi Li, Mingxuan Yu, Yuhui Fan, Haibin Niu, Li Liu, Chao Zhou, Guangfeng Wu.  (2023)  Interfacial and interlayer enhancement of highly hydrophilic dual-affinity waterborne polyurethane sizing agent acting on carbon fiber/epoxy resin composites.  PROGRESS IN ORGANIC COATINGS,  183  (107687).  [PMID:] [10.1016/j.porgcoat.2023.107687]
2. Guiyan Yang, Youyi Sun, Limin qin, Mengru Li, Kangtai Ou, Jiang Fang, Qiang Fu.  (2021)  Direct-ink-writing (DIW) 3D printing functional composite materials based on supra-molecular interaction.  COMPOSITES SCIENCE AND TECHNOLOGY,  215  (109013).  [PMID:] [10.1016/j.compscitech.2021.109013]
3. Kai Hu, Tiantian Pang, Yanmei Shi, Pengzhao Han, Yuanqing Zhao, Wenjie Zhao, Huahui Zeng, Shusheng Zhang, Zhenqiang Zhang.  (2021)  Magnetic borate-modified Mxene: A highly affinity material for the extraction of catecholamines.  ANALYTICA CHIMICA ACTA,  1176  (338769).  [PMID:34399896] [10.1016/j.aca.2021.338769]
4. Weilu Liu, Fan Cui, Haifeng Li, Shuang Wang, Beibei Zhuo, Shuang Wang.  (2020)  Three-dimensional hybrid networks of molecularly imprinted poly(9-carbazoleacetic acid) and MWCNTs for simultaneous voltammetric determination of dopamine and epinephrine in plasma sample.  SENSORS AND ACTUATORS B-CHEMICAL,  323  (128669).  [PMID:] [10.1016/j.snb.2020.128669]
5. Dan Wang, Zhigang Xu, Yuanchen Liu, Yujian Liu, Gongke Li, Xiaoxi Si, Tao Lin, Hongcheng Liu, Zhimin Liu.  (2020)  Molecularly imprinted polymer-based fiber array extraction of eight estrogens from environmental water samples prior to high-performance liquid chromatography analysis.  MICROCHEMICAL JOURNAL,  159  (105376).  [PMID:] [10.1016/j.microc.2020.105376]
6. Li Chi, Zhang Yuanyuan, Li Chunya, Wan Qijin, Ke Qiang, Yang Nianjun.  (2020)  Tailoring the CeO2 morphology and its electrochemical reactivity for highly sensitive and selective determination of dopamine and epinephrine.  MICROCHIMICA ACTA,  187  (2): (1-9).  [PMID:31965337] [10.1007/s00604-019-4100-7]
7. Qiwen Wang, Haipei Si, Lihui Zhang, Ling Li, Xiaohong Wang, Shengtian Wang.  (2020)  A fast and facile electrochemical method for the simultaneous detection of epinephrine, uric acid and folic acid based on ZrO2/ZnO nanocomposites as sensing material.  ANALYTICA CHIMICA ACTA,  1104  (69).  [PMID:32106959] [10.1016/j.aca.2020.01.012]
8. Chen Li, Xuejuan Chen, Zhe Zhang, Jilin Tang, Bailin Zhang.  (2018)  Gold Nanoparticle-DNA conjugates enhanced determination of dopamine by aptamer-based microcantilever array sensor.  SENSORS AND ACTUATORS B-CHEMICAL,  275  (25).  [PMID:] [10.1016/j.snb.2018.08.024]
9. Yi Xin, Wu Yuxuan, Tan Guoxin, Yu Peng, Zhou Lei, Zhou Zhengnan, Chen Junqi, Wang Zhengao, Pang Jinshan, Ning Chengyun.  (2017)  Palladium nanoparticles entrapped in a self-supporting nanoporous gold wire as sensitive dopamine biosensor.  Scientific Reports,  (1): (1-9).  [PMID:28801614] [10.1038/s41598-017-07909-y]
10. Hongmei Chen, Han Zhang, Ruo Yuan, Shihong Chen.  (2017)  Novel Double-Potential Electrochemiluminescence Ratiometric Strategy in Enzyme-Based Inhibition Biosensing for Sensitive Detection of Organophosphorus Pesticides.  ANALYTICAL CHEMISTRY,  89  (5): (2823–2829).  [PMID:28192982] [10.1021/acs.analchem.6b03883]
11. Lin Jiang, Shuqing Gu, Yaping Ding, Daixin Ye, Zhen Zhang, Fenfen Zhang.  (2013)  Amperometric sensor based on tricobalt tetroxide nanoparticles–graphene nanocomposite film modified glassy carbon electrode for determination of tyrosine.  COLLOIDS AND SURFACES B-BIOINTERFACES,  107  (146).  [PMID:23475062] [10.1016/j.colsurfb.2013.01.077]
12. Xiao Liu, Liqiang Luo, Yaping Ding, Qingsheng Wu, Youli Wei, Daixin Ye.  (2012)  A highly sensitive method for determination of guanine, adenine and epinephrine using poly-melamine film modified glassy carbon electrode.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  675  (47).  [PMID:] [10.1016/j.jelechem.2012.04.026]

References

1. Xin Song, Jiaqi Li, Mingxuan Yu, Yuhui Fan, Haibin Niu, Li Liu, Chao Zhou, Guangfeng Wu.  (2023)  Interfacial and interlayer enhancement of highly hydrophilic dual-affinity waterborne polyurethane sizing agent acting on carbon fiber/epoxy resin composites.  PROGRESS IN ORGANIC COATINGS,  183  (107687).  [PMID:] [10.1016/j.porgcoat.2023.107687]
2. Guiyan Yang, Youyi Sun, Limin qin, Mengru Li, Kangtai Ou, Jiang Fang, Qiang Fu.  (2021)  Direct-ink-writing (DIW) 3D printing functional composite materials based on supra-molecular interaction.  COMPOSITES SCIENCE AND TECHNOLOGY,  215  (109013).  [PMID:] [10.1016/j.compscitech.2021.109013]
3. Kai Hu, Tiantian Pang, Yanmei Shi, Pengzhao Han, Yuanqing Zhao, Wenjie Zhao, Huahui Zeng, Shusheng Zhang, Zhenqiang Zhang.  (2021)  Magnetic borate-modified Mxene: A highly affinity material for the extraction of catecholamines.  ANALYTICA CHIMICA ACTA,  1176  (338769).  [PMID:34399896] [10.1016/j.aca.2021.338769]
4. Weilu Liu, Fan Cui, Haifeng Li, Shuang Wang, Beibei Zhuo, Shuang Wang.  (2020)  Three-dimensional hybrid networks of molecularly imprinted poly(9-carbazoleacetic acid) and MWCNTs for simultaneous voltammetric determination of dopamine and epinephrine in plasma sample.  SENSORS AND ACTUATORS B-CHEMICAL,  323  (128669).  [PMID:] [10.1016/j.snb.2020.128669]
5. Dan Wang, Zhigang Xu, Yuanchen Liu, Yujian Liu, Gongke Li, Xiaoxi Si, Tao Lin, Hongcheng Liu, Zhimin Liu.  (2020)  Molecularly imprinted polymer-based fiber array extraction of eight estrogens from environmental water samples prior to high-performance liquid chromatography analysis.  MICROCHEMICAL JOURNAL,  159  (105376).  [PMID:] [10.1016/j.microc.2020.105376]
6. Li Chi, Zhang Yuanyuan, Li Chunya, Wan Qijin, Ke Qiang, Yang Nianjun.  (2020)  Tailoring the CeO2 morphology and its electrochemical reactivity for highly sensitive and selective determination of dopamine and epinephrine.  MICROCHIMICA ACTA,  187  (2): (1-9).  [PMID:31965337] [10.1007/s00604-019-4100-7]
7. Qiwen Wang, Haipei Si, Lihui Zhang, Ling Li, Xiaohong Wang, Shengtian Wang.  (2020)  A fast and facile electrochemical method for the simultaneous detection of epinephrine, uric acid and folic acid based on ZrO2/ZnO nanocomposites as sensing material.  ANALYTICA CHIMICA ACTA,  1104  (69).  [PMID:32106959] [10.1016/j.aca.2020.01.012]
8. Chen Li, Xuejuan Chen, Zhe Zhang, Jilin Tang, Bailin Zhang.  (2018)  Gold Nanoparticle-DNA conjugates enhanced determination of dopamine by aptamer-based microcantilever array sensor.  SENSORS AND ACTUATORS B-CHEMICAL,  275  (25).  [PMID:] [10.1016/j.snb.2018.08.024]
9. Yi Xin, Wu Yuxuan, Tan Guoxin, Yu Peng, Zhou Lei, Zhou Zhengnan, Chen Junqi, Wang Zhengao, Pang Jinshan, Ning Chengyun.  (2017)  Palladium nanoparticles entrapped in a self-supporting nanoporous gold wire as sensitive dopamine biosensor.  Scientific Reports,  (1): (1-9).  [PMID:28801614] [10.1038/s41598-017-07909-y]
10. Hongmei Chen, Han Zhang, Ruo Yuan, Shihong Chen.  (2017)  Novel Double-Potential Electrochemiluminescence Ratiometric Strategy in Enzyme-Based Inhibition Biosensing for Sensitive Detection of Organophosphorus Pesticides.  ANALYTICAL CHEMISTRY,  89  (5): (2823–2829).  [PMID:28192982] [10.1021/acs.analchem.6b03883]
11. Lin Jiang, Shuqing Gu, Yaping Ding, Daixin Ye, Zhen Zhang, Fenfen Zhang.  (2013)  Amperometric sensor based on tricobalt tetroxide nanoparticles–graphene nanocomposite film modified glassy carbon electrode for determination of tyrosine.  COLLOIDS AND SURFACES B-BIOINTERFACES,  107  (146).  [PMID:23475062] [10.1016/j.colsurfb.2013.01.077]
12. Xiao Liu, Liqiang Luo, Yaping Ding, Qingsheng Wu, Youli Wei, Daixin Ye.  (2012)  A highly sensitive method for determination of guanine, adenine and epinephrine using poly-melamine film modified glassy carbon electrode.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,  675  (47).  [PMID:] [10.1016/j.jelechem.2012.04.026]

Solution Calculators