DL-Kynurenine - ≥95.0%, high purity , CAS No.343-65-7

  • ≥95%
Item Number
R134932
Grouped product items
SKUSizeAvailabilityPrice Qty
R134932-250mg
250mg
In stock
$106.90
R134932-1g
1g
In stock
$404.90

Basic Description

Synonyms.alpha.-2-diamino-.gamma.-oxobenzenebutyric acid | alpha,2-Diamino-gamma-oxobenzenebutanoic acid | Benzenebutanoic acid, alpha,2-diamino-gamma-oxo- | (+-)-Kynurenine | 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid # | NCGC00095648-01 | Spectrum_001162 | SR
Specifications & Purity≥95%
Shipped InNormal
Product Description

A tryptophan metabolite, and a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor.

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KMT2A Tchem Histone-lysine N-methyltransferase 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid
INCHI InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)
InChi Key YGPSJZOEDVAXAB-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N
Isomeric SMILES C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N
WGK Germany 3
PubChem CID 846
Molecular Weight 208.21
Beilstein 2697333

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
G2221104Certificate of AnalysisMay 21, 2024 R134932
G2221158Certificate of AnalysisMay 21, 2024 R134932
L2108778Certificate of AnalysisSep 19, 2023 R134932
L2108779Certificate of AnalysisSep 19, 2023 R134932
L1910184Certificate of AnalysisJul 07, 2023 R134932

Chemical and Physical Properties

Melt Point(°C)~235°C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Citations of This Product

1. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707] [10.1016/j.carbpol.2023.120986]
2. Zhuoting Liu, Yunfang Ping, Lumei Zhang, Jingran Zhang, Ann Van Schepdael, Xu Wang.  (2023)  Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee.  Food Chemistry-X,  17  (100591).  [PMID:36845477] [10.1016/j.fochx.2023.100591]
3. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1199  (123249).  [PMID:35447521] [10.1016/j.jchromb.2022.123249]
4. Mengmeng Song, Xianjie Sheng, Genyi Ye, Zhuicheng Xu, Xinru Li, Tong Xie, Haishan Deng, An Kang.  (2022)  Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  212  (114641).  [PMID:35182828] [10.1016/j.jpba.2022.114641]
5. Jia Yin, Yujie Song, Yaozhong Hu, Yuanyifei Wang, Bowei Zhang, Jin Wang, Xuemeng Ji, Shuo Wang.  (2021)  Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study.  Microorganisms,  (7): (1511).  [PMID:34361945] [10.3390/microorganisms9071511]
6. Yuanyuan Xia, Faqiong Zhao, Baizhao Zeng.  (2020)  A molecularly imprinted copolymer based electrochemical sensor for the highly sensitive detection of L-Tryptophan.  TALANTA,  206  (120245).  [PMID:31514823] [10.1016/j.talanta.2019.120245]
7. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao.  (2017-03-28)  Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease..  Redox biology,  12  (505-521).  [PMID:28343144]

References

1. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707] [10.1016/j.carbpol.2023.120986]
2. Zhuoting Liu, Yunfang Ping, Lumei Zhang, Jingran Zhang, Ann Van Schepdael, Xu Wang.  (2023)  Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee.  Food Chemistry-X,  17  (100591).  [PMID:36845477] [10.1016/j.fochx.2023.100591]
3. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1199  (123249).  [PMID:35447521] [10.1016/j.jchromb.2022.123249]
4. Mengmeng Song, Xianjie Sheng, Genyi Ye, Zhuicheng Xu, Xinru Li, Tong Xie, Haishan Deng, An Kang.  (2022)  Selective enrichment of microbiota-derived tryptophan metabolites in mouse faeces based on molecularly imprinted solid-phase extraction for HPLC analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  212  (114641).  [PMID:35182828] [10.1016/j.jpba.2022.114641]
5. Jia Yin, Yujie Song, Yaozhong Hu, Yuanyifei Wang, Bowei Zhang, Jin Wang, Xuemeng Ji, Shuo Wang.  (2021)  Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study.  Microorganisms,  (7): (1511).  [PMID:34361945] [10.3390/microorganisms9071511]
6. Yuanyuan Xia, Faqiong Zhao, Baizhao Zeng.  (2020)  A molecularly imprinted copolymer based electrochemical sensor for the highly sensitive detection of L-Tryptophan.  TALANTA,  206  (120245).  [PMID:31514823] [10.1016/j.talanta.2019.120245]
7. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao.  (2017-03-28)  Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease..  Redox biology,  12  (505-521).  [PMID:28343144]

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