Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. Ck2 Inhibitor II inhibits CK2 in rat liver with 1,300-fold greater selectivity for CK2 than for CK1 (IC50 = 140 nM and >200 μM respectively)
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Product Description
DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM
1.Pagano MA, Meggio F, Ruzzene M, Andrzejewska M, Kazimierczuk Z, Pinna LA. (2004) 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.. Biochem Biophys Res Commun, 321 (4):(1040-4). [PMID:15358133]
2.Pagano MA, Andrzejewska M, Ruzzene M, Sarno S, Cesaro L, Bain J, Elliott M, Meggio F, Kazimierczuk Z, Pinna LA. (2004) Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.. J Med Chem, 47 (25):(6239-47). [PMID:15566294]
3.Ulges A, Witsch EJ, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou N, Dietzen S et al.. (2016) Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.. Proc Natl Acad Sci USA, 113 (36):(10145-50). [PMID:27555590]
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L1811244