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DMH-1 - 10mM in DMSO, high purity , CAS No.1206711-16-1
Selective BMP-1 receptor inhibitor
Basic Description Synonyms DMH-1 | 1206711-16-1 | DMH1 | 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | DMH 1 | 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | CHEBI:86289 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 4-(6-{4 Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway. Storage Temp Protected from light,Store at -80°C Shipped In Ice chest + Ice pads Product Description DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline INCHI InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3 InChi Key JMIFGARJSWXZSH-UHFFFAOYSA-N Canonical SMILES CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2 Isomeric SMILES CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2 PubChem CID 50997747 Molecular Weight 380.44
Chemical and Physical Properties Sensitivity Heat& Moisture&Light sensitive Melt Point(°C) 176.0 to 180.0 °C
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
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