DMH2 - ≥98%(HPLC), high purity , CAS No.1206711-14-9

Item Number

D287316

Grouped product items
SKU	Size	Availability	Price	Qty
D287316-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$201.90
D287316-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$846.90

Type I BMP receptor inhibitor

Basic Description

Synonyms	4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Type I BMP receptor inhibitor (Kivalues are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki= 85 nM). Decreases growth and induces cell death of H1299
Storage Temp	Store at 2-8°C
Shipped In	Wet ice

Associated Targets(Human)

PRKAB1 Tchem AMP-activated protein kinase, beta-1 subunit (56 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGFBR1 Tchem TGF-beta receptor type I (3786 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACVR1 Tchem Activin receptor type-1 (1516 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[2-[4-(3-quinolin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
INCHI	InChI=1S/C27H25N5O2/c1-2-4-26-24(3-1)23(9-10-28-26)25-18-30-32-19-21(17-29-27(25)32)20-5-7-22(8-6-20)34-16-13-31-11-14-33-15-12-31/h1-10,17-19H,11-16H2
InChi Key	DXLXRNZCYAYUED-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
Isomeric SMILES	C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
PubChem CID	50997748
Molecular Weight	451.52

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Basic Description