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DMH2 - ≥98%(HPLC), high purity , CAS No.1206711-14-9
Type I BMP receptor inhibitor
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Type I BMP receptor inhibitor (Kivalues are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki= 85 nM). Decreases growth and induces cell death of H1299 Storage Temp Store at 2-8°C Shipped In Wet ice
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-[2-[4-(3-quinolin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine INCHI InChI=1S/C27H25N5O2/c1-2-4-26-24(3-1)23(9-10-28-26)25-18-30-32-19-21(17-29-27(25)32)20-5-7-22(8-6-20)34-16-13-31-11-14-33-15-12-31/h1-10,17-19H,11-16H2 InChi Key DXLXRNZCYAYUED-UHFFFAOYSA-N Canonical SMILES C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3 Isomeric SMILES C1COCCN1CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3 PubChem CID 50997748 Molecular Weight 451.52
Chemical and Physical Properties Solubility Solvent:2eq.HCl, Max Conc. mg/mL: 22.58, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 9.03, Max Conc. mM: 20 with gentle warming
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