DMP 543 - 98%, high purity , CAS No.160588-45-4

  • ≥98%
Item Number
D288728
Grouped product items
SKUSizeAvailabilityPrice Qty
D288728-5mg
5mg
In stock
$83.90
D288728-10mg
10mg
In stock
$129.90
D288728-25mg
25mg
In stock
$290.90
D288728-50mg
50mg
In stock
$528.90
D288728-100mg
100mg
In stock
$950.90
D288728-200mg
200mg
In stock
$1,711.90

ACh release enhancer

Basic Description

Synonyms160588-45-4 | DMP 543 | DMP-543 | XR-543 | 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE | 10,10-Bis((2-fluoropyridin-4-yl)methyl)anthracen-9(10H)-one | CHEMBL343822 | DYD4418J7V | DP-543 | 10,10-Bis((2-fluoro-4-pyridyl)methyl)anthrone | 10,10-bis(2-fluoro-4-py
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAcetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50= 700 nM), and increases release of dopamine and glutamate (EC50values are 0.25 and 0.22μM, respectively). Orally activein vivo; increases
Storage TempStore at 2-8°C
Shipped InWet ice

Associated Targets(Human)

KCNQ2 Tclin Potassium voltage-gated channel subfamily KQT member 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNQ2 Tclin Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) (372 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Kcnq2 Voltage-gated potassium channel subunit Kv7.2 (95 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488196401
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488196401
IUPAC Name 10,10-bis[(2-fluoropyridin-4-yl)methyl]anthracen-9-one
INCHI InChI=1S/C26H18F2N2O/c27-23-13-17(9-11-29-23)15-26(16-18-10-12-30-24(28)14-18)21-7-3-1-5-19(21)25(31)20-6-2-4-8-22(20)26/h1-14H,15-16H2
InChi Key MUJBUUDUXGDXLW-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC(=NC=C4)F)CC5=CC(=NC=C5)F
Isomeric SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC(=NC=C4)F)CC5=CC(=NC=C5)F
PubChem CID 9887884
Molecular Weight 412.44

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Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
C2321722Certificate of AnalysisMar 09, 2023 D288728
C2321741Certificate of AnalysisMar 09, 2023 D288728
C2321748Certificate of AnalysisMar 09, 2023 D288728
C2321754Certificate of AnalysisMar 09, 2023 D288728
C2321755Certificate of AnalysisMar 09, 2023 D288728
C2321758Certificate of AnalysisMar 09, 2023 D288728
C2321760Certificate of AnalysisMar 09, 2023 D288728
C2321761Certificate of AnalysisMar 09, 2023 D288728
C2321768Certificate of AnalysisMar 09, 2023 D288728
C2321775Certificate of AnalysisMar 09, 2023 D288728
C2321778Certificate of AnalysisMar 09, 2023 D288728
C2321789Certificate of AnalysisMar 09, 2023 D288728

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 41.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.62, Max Conc. mM: 50

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