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Basic Description
| Specifications & Purity | ≥98% |
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| Biochemical and Physiological Mechanisms | DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC 50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising l |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC 50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress Form:Solid IC50& Target:IC50: 20 μM (DNA2 nuclease) |
Associated Targets(Human)
ALB Tchem Serum albumin (2651 Activities)
CASP6 Tchem Caspase-6 (1213 Activities)
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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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DLD-1 (17511 Activities)
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HCT-8 (3484 Activities)
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HT-29 (80576 Activities)
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MCF-10A (2462 Activities)
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MCF7 (126967 Activities)
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PC-3 (62116 Activities)
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U2OS (164939 Activities)
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A549 (127892 Activities)
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FHC (113 Activities)
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HCT-116 (91556 Activities)
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WiDr (1835 Activities)
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NCI-H460 (60772 Activities)
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MDA-MB-231 (73002 Activities)
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FEN1 Tchem Flap endonuclease 1 (12055 Activities)
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CWR22R (2180 Activities)
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IMR-90 (216 Activities)
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POLI Tchem DNA polymerase iota (116820 Activities)
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POLH Tchem DNA polymerase eta (21678 Activities)
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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
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NCI-H2030 (117 Activities)
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GMNN Tbio Geminin (128009 Activities)
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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
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CTDSP1 Tchem Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (1031 Activities)
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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
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WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)
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LNCaP C4-2 (165 Activities)
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RWPE-1 (201 Activities)
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DNA2 Tbio DNA replication ATP-dependent helicase/nuclease DNA2 (97 Activities)
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Associated Targets(non-human)
pol Human immunodeficiency virus type 1 integrase (9041 Activities)
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Saccharomyces cerevisiae (19171 Activities)
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Genome polyprotein (620 Activities)
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dengue virus type 2 (2400 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Canonical SMILES | C1=CC2=C(C(=C1)[N+](=O)[O-])NC=C(C2=O)C(=O)O |
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| Isomeric SMILES | C1=CC2=C(C(=C1)[N+](=O)[O-])NC=C(C2=O)C(=O)O |
| PubChem CID | 225906 |
| Molecular Weight | 234.17 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Solubility | DMSO : 31.25 mg/mL (133.45 mM; Need ultrasonic) |
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