Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D107320-10mg | 10mg | In stock | $19.90 | |
D107320-20mg | 20mg | In stock | $24.90 | |
D107320-50mg | 50mg | In stock | $36.90 | |
D107320-100mg | 100mg | In stock | $53.90 | |
D107320-250mg | 250mg | In stock | $89.90 | |
D107320-500mg | 500mg | In stock | $129.90 | |
D107320-1g | 1g | In stock | $187.90 | |
D107320-5g | 5g | In stock | $657.90 |
Potent cytotoxic agent
Synonyms | docetaxel | 114977-28-5 | Taxotere | Docetaxel anhydrous | Docetaxol | Docetaxel Winthrop | EmDOC | RP-56976 | Docetaxolum | Docefrez | Taxoel | Docetaxel Kabi | Docetaxel [INN] | Docecad | NSC 628503 | DTXSID0040464 | Docetaxel Teva | Docetaxel Accord | N-debenzoyl-N-tert-butoxycarbonyl-10 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β?tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.Potent cytotoxic agent in v |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of tubulin beta class I |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
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IUPAC Name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
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INCHI | InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1 |
InChi Key | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
Canonical SMILES | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
Isomeric SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
WGK Germany | 3 |
RTECS | DA4172750 |
PubChem CID | 148124 |
Molecular Weight | 807.88 |
DrugBank Ligand | DB01248 |
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PubChem CID | 148124 |
CAS Registry No. | 114977-28-5 |
ChEMBL Ligand | CHEMBL92 |
ChEBI | CHEBI:4672 |
Wikipedia | Docetaxel |
RCSB PDB Ligand | TXL |
PEP | docetaxel |
DrugCentral Ligand | 939 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2409335 | Certificate of Analysis | Aug 19, 2024 | D107320 |
H2409336 | Certificate of Analysis | Aug 19, 2024 | D107320 |
K1820061 | Certificate of Analysis | Apr 26, 2024 | D107320 |
K2111810 | Certificate of Analysis | Jan 04, 2024 | D107320 |
C2205397 | Certificate of Analysis | Dec 11, 2023 | D107320 |
C2205403 | Certificate of Analysis | Dec 11, 2023 | D107320 |
C2205575 | Certificate of Analysis | Dec 11, 2023 | D107320 |
F1828013 | Certificate of Analysis | Nov 07, 2023 | D107320 |
I2306404 | Certificate of Analysis | Sep 16, 2023 | D107320 |
I2306402 | Certificate of Analysis | Sep 16, 2023 | D107320 |
I2306352 | Certificate of Analysis | Sep 16, 2023 | D107320 |
I2304603 | Certificate of Analysis | Sep 16, 2023 | D107320 |
I2306356 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306355 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306354 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306353 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306357 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306381 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I2306382 | Certificate of Analysis | Sep 11, 2023 | D107320 |
I1924081 | Certificate of Analysis | Apr 11, 2023 | D107320 |
B2306919 | Certificate of Analysis | Feb 11, 2023 | D107320 |
D2122188 | Certificate of Analysis | Jan 17, 2023 | D107320 |
I2219402 | Certificate of Analysis | Sep 22, 2022 | D107320 |
G2227730 | Certificate of Analysis | Jul 30, 2022 | D107320 |
K1820062 | Certificate of Analysis | Jul 11, 2022 | D107320 |
D2313829 | Certificate of Analysis | Mar 11, 2022 | D107320 |
C2205404 | Certificate of Analysis | Mar 11, 2022 | D107320 |
C2205402 | Certificate of Analysis | Mar 11, 2022 | D107320 |
B2306918 | Certificate of Analysis | Mar 11, 2022 | D107320 |
Melt Point(°C) | 186-191°C |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H341:Suspected of causing genetic defects H351:Suspected of causing cancer H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DA4172750 |
1. Wei Pei, Yuqing Li, Yixian Wu, Yuan Wu, Ling Cai, Shaozhuo Wang, Shoulin Wang, Jin Chen. (2023) A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer. ADVANCED FUNCTIONAL MATERIALS, (2308117). [PMID:19463981] |
2. Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li. (2023) Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy Through Disrupting Microtubule and Actins Dynamics. ADVANCED MATERIALS, (2303962). [PMID:37392034] |
3. Zhuang Yu, Wang Yuxiao, Li Ning, Meng Haitao, Li Zhiyu, Luo Jianguang, Qiu Zhixia. (2023) Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 48 (4): (363-376). [PMID:37344636] |
4. Jiawei Li, Chunmei Fan, Zhongyang Lv, Ziying Sun, Jie Han, Maochun Wang, Huiming Jiang, Kuoyang Sun, Guihua Tan, Hu Guo, Anlong Liu, Heng Sun, Xingquan Xu, Rui Wu, Wenjin Yan, Qing Jiang, Shiro Ikegawa, Xiao Chen, Dongquan Shi. (2023) Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration. Theranostics, 13 (10): ( 3480–3496). [PMID:37351173] |
5. Rengui Xu, Honglian Guo, Xiuli Chen, Jiarong Xu, Yusheng Gong, Peng Cao, Chunyu Wei, Fei Xiao, Di Wu, Wei Chen, Lin Wang, Zheng Wang. (2023) Smart hydrothermally responsive microneedle for topical tumor treatment. JOURNAL OF CONTROLLED RELEASE, 358 (566). [PMID:37182803] |
6. Qinhui Ren, Yufu Ma, Fuhua Wei, Lan Qin, Hongliang Chen, Zhao Liang, Siyuan Wang. (2023) Preparation of Zr-MOFs for the adsorption of doxycycline hydrochloride from wastewater. Green Processing and Synthesis, 12 (1): [PMID:] |
7. Tan Hu, Yang Xu, Gang Xu. (2023) Dipeptide-polysaccharides hydrogels through co-assembly. FOOD CHEMISTRY, 422 (136272). [PMID:37141751] |
8. Fang Fang, Shaohua Zhang, Chaofan Chen, Xueying Wang, Chuannan Luo, Qin Wei. (2023) A fluorescent nanoprobe based on N/S co-doped carbon dots coupled with molecularly imprinted polymers for the detection of curcumin. OPTICAL MATERIALS, 139 (113800). [PMID:] |
9. Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang. (2023) Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel. International Journal of Nanomedicine, [PMID:32982230] |
10. Tong Le, Zhou ZeYang, Wang Gang, Wu Chao. (2023) A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism. Drug Delivery and Translational Research, 13 (4): (983-993). [PMID:36515864] |
11. Li Huang, Huaqiang Fang, Teng Zhang, Binbin Hu, Shichen Liu, Fanzhen Lv, Zhaoxia Zeng, Huijie Liu, Weimin Zhou, Xiaolei Wang. (2023) Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment. Bioactive Materials, 23 (526). [PMID:36514389] |
12. Ruifeng Wu, Zhiqiang Zhang, Baohua Wang, Ge Chen, Yaozhong Zhang, Haowen Deng, Zilong Tang, Junjie Mao, Lei Wang. (2022) Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles. Drug Design Development and Therapy, [PMID:32606595] |
13. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan. (2022) Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release. ChemistrySelect, 7 (30): (e202200670). [PMID:] |
14. Hongming Liu, Qin Zhou, Yongfu Lian. (2022) Polymethyl(1–Butyric acidyl)silane–Assisted Dispersion and Density Gradient Ultracentrifugation Separation of Single–Walled Carbon Nanotubes. Nanomaterials, 12 (12): (2094). [PMID:35745430] |
15. Lingling Xu, Chuan Zhou, Fan Wang, Huiqin Liu, Guangyuan Dong, Siyi Zhang, Tao Liu. (2022) Functional drug carriers formed by RGD-modified β-CD-HPG for the delivery of docetaxel for targeted inhibition of nasopharyngeal carcinoma cells. RSC Advances, 12 (28): (18004-18011). [PMID:35765336] |
16. Wei Pei, Ling Cai, Xing Gong, Li Zhang, Jiarong Zhang, Ping Zhu, Huijun Jiang, Chao Wang, Shoulin Wang, Jin Chen. (2022) Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy. Materials Today Bio, 15 (100272). [PMID:35607417] |
17. Yingying Zhang, Hongxia Duan, Heming Zhao, Lingling Qi, Yanhong Liu, Zheao Zhang, Chao Liu, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang. (2022) Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment. Pharmaceutics, 14 (5): (964). [PMID:35631549] |
1. Purba TS et al.. (2019) CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.. EMBO Mol Med, 11 (10): (e11031). [PMID:31512803] |
2. Zeng J et al.. (2018) PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy.. Theranostics, 8 (109-123). [PMID:29290796] |
3. Kurniawan W et al.. (2020) The effects of docetaxel and/or captopril in expression of TGF-β1, MMP-1, CTGF, and PAI-1 as markers of anterior urethral stricture in an animal model.. Ther Adv Urol, 12 (1756287220927994). [PMID:35173811] |
4. Wei Pei, Yuqing Li, Yixian Wu, Yuan Wu, Ling Cai, Shaozhuo Wang, Shoulin Wang, Jin Chen. (2023) A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer. ADVANCED FUNCTIONAL MATERIALS, (2308117). [PMID:19463981] |
5. Shuncheng Yao, Shaobo Wang, Minjia Zheng, Zhuo Wang, Zhirong Liu, Zhong Lin Wang, Linlin Li. (2023) Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy Through Disrupting Microtubule and Actins Dynamics. ADVANCED MATERIALS, (2303962). [PMID:37392034] |
6. Zhuang Yu, Wang Yuxiao, Li Ning, Meng Haitao, Li Zhiyu, Luo Jianguang, Qiu Zhixia. (2023) Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 48 (4): (363-376). [PMID:37344636] |
7. Jiawei Li, Chunmei Fan, Zhongyang Lv, Ziying Sun, Jie Han, Maochun Wang, Huiming Jiang, Kuoyang Sun, Guihua Tan, Hu Guo, Anlong Liu, Heng Sun, Xingquan Xu, Rui Wu, Wenjin Yan, Qing Jiang, Shiro Ikegawa, Xiao Chen, Dongquan Shi. (2023) Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration. Theranostics, 13 (10): ( 3480–3496). [PMID:37351173] |
8. Rengui Xu, Honglian Guo, Xiuli Chen, Jiarong Xu, Yusheng Gong, Peng Cao, Chunyu Wei, Fei Xiao, Di Wu, Wei Chen, Lin Wang, Zheng Wang. (2023) Smart hydrothermally responsive microneedle for topical tumor treatment. JOURNAL OF CONTROLLED RELEASE, 358 (566). [PMID:37182803] |
9. Qinhui Ren, Yufu Ma, Fuhua Wei, Lan Qin, Hongliang Chen, Zhao Liang, Siyuan Wang. (2023) Preparation of Zr-MOFs for the adsorption of doxycycline hydrochloride from wastewater. Green Processing and Synthesis, 12 (1): [PMID:] |
10. Tan Hu, Yang Xu, Gang Xu. (2023) Dipeptide-polysaccharides hydrogels through co-assembly. FOOD CHEMISTRY, 422 (136272). [PMID:37141751] |
11. Fang Fang, Shaohua Zhang, Chaofan Chen, Xueying Wang, Chuannan Luo, Qin Wei. (2023) A fluorescent nanoprobe based on N/S co-doped carbon dots coupled with molecularly imprinted polymers for the detection of curcumin. OPTICAL MATERIALS, 139 (113800). [PMID:] |
12. Zhen Yu, Xundou Li, Jinhong Duan, Xian-Da Yang. (2023) Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel. International Journal of Nanomedicine, [PMID:32982230] |
13. Tong Le, Zhou ZeYang, Wang Gang, Wu Chao. (2023) A self-microemulsion enhances oral absorption of docetaxel by inhibiting P-glycoprotein and CYP metabolism. Drug Delivery and Translational Research, 13 (4): (983-993). [PMID:36515864] |
14. Li Huang, Huaqiang Fang, Teng Zhang, Binbin Hu, Shichen Liu, Fanzhen Lv, Zhaoxia Zeng, Huijie Liu, Weimin Zhou, Xiaolei Wang. (2023) Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment. Bioactive Materials, 23 (526). [PMID:36514389] |
15. Ruifeng Wu, Zhiqiang Zhang, Baohua Wang, Ge Chen, Yaozhong Zhang, Haowen Deng, Zilong Tang, Junjie Mao, Lei Wang. (2022) Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles. Drug Design Development and Therapy, [PMID:32606595] |
16. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan. (2022) Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release. ChemistrySelect, 7 (30): (e202200670). [PMID:] |
17. Hongming Liu, Qin Zhou, Yongfu Lian. (2022) Polymethyl(1–Butyric acidyl)silane–Assisted Dispersion and Density Gradient Ultracentrifugation Separation of Single–Walled Carbon Nanotubes. Nanomaterials, 12 (12): (2094). [PMID:35745430] |
18. Lingling Xu, Chuan Zhou, Fan Wang, Huiqin Liu, Guangyuan Dong, Siyi Zhang, Tao Liu. (2022) Functional drug carriers formed by RGD-modified β-CD-HPG for the delivery of docetaxel for targeted inhibition of nasopharyngeal carcinoma cells. RSC Advances, 12 (28): (18004-18011). [PMID:35765336] |
19. Wei Pei, Ling Cai, Xing Gong, Li Zhang, Jiarong Zhang, Ping Zhu, Huijun Jiang, Chao Wang, Shoulin Wang, Jin Chen. (2022) Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy. Materials Today Bio, 15 (100272). [PMID:35607417] |
20. Yingying Zhang, Hongxia Duan, Heming Zhao, Lingling Qi, Yanhong Liu, Zheao Zhang, Chao Liu, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang. (2022) Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment. Pharmaceutics, 14 (5): (964). [PMID:35631549] |