Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β?tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.Potent cytotoxic agent in v
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of tubulin beta class I
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Docetaxel(Taxotere), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle.
Associated Targets
CTNNBIP1Tbio Beta-catenin-interacting protein 1 0 Activities
1.Purba TS et al.. (2019) CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.. EMBO Mol Med, 11 (10):(e11031). [PMID:31512803]
2.Zeng J et al.. (2018) PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy.. Theranostics, 8 (109-123). [PMID:29290796]
3.Kurniawan W et al.. (2020) The effects of docetaxel and/or captopril in expression of TGF-β1, MMP-1, CTGF, and PAI-1 as markers of anterior urethral stricture in an animal model.. Ther Adv Urol, 12 (1756287220927994). [PMID:35173811]
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