Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D105295-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 | |
D105295-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $249.90 | |
D105295-250g | 250g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $499.90 | |
D105295-500g | 500g | In stock | $799.90 |
Synonyms | DTAC | Arquad 12-23 | dodecyl(trimethyl)ammonium chloride | EINECS 203-927-0 | Dodecyltrimethylammonium chloride 100 microg/mL in Acetonitrile | DTAC | LAURTRIMONIUM CHLORIDE [INCI] | Q-201039 | Empigen 5089 | DODECYL TRIMETHYL AMMONIUM CHLORIDE | NCGC001 |
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Specifications & Purity | ≥99% |
Storage Temp | Argon charged |
Shipped In | Normal |
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IUPAC Name | dodecyl(trimethyl)azanium;chloride |
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INCHI | InChI=1S/C15H34N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16(2,3)4;/h5-15H2,1-4H3;1H/q+1;/p-1 |
InChi Key | DDXLVDQZPFLQMZ-UHFFFAOYSA-M |
Canonical SMILES | CCCCCCCCCCCC[N+](C)(C)C.[Cl-] |
Isomeric SMILES | CCCCCCCCCCCC[N+](C)(C)C.[Cl-] |
PubChem CID | 8152 |
UN Number | 3077 |
Packing Group | III |
Molecular Weight | 263.89 |
Beilstein | 3915951 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2003176 | Certificate of Analysis | May 09, 2024 | D105295 |
E2325813 | Certificate of Analysis | May 11, 2023 | D105295 |
E2325842 | Certificate of Analysis | May 11, 2023 | D105295 |
E2325877 | Certificate of Analysis | May 11, 2023 | D105295 |
F2312813 | Certificate of Analysis | May 11, 2023 | D105295 |
F2312831 | Certificate of Analysis | May 11, 2023 | D105295 |
F2312832 | Certificate of Analysis | May 11, 2023 | D105295 |
F2218380 | Certificate of Analysis | Jun 08, 2022 | D105295 |
G1825039 | Certificate of Analysis | May 11, 2022 | D105295 |
D2214022 | Certificate of Analysis | Jun 21, 2021 | D105295 |
Sensitivity | Hygroscopic.Heat Sensitive |
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Melt Point(°C) | 246°C |
Pictogram(s) | GHS09, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H314:Causes severe skin burns and eye damage H302:Harmful if swallowed H318:Causes serious eye damage H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
Class | 9 |
1. Hao Nan Qiu, Xing Peng Hao, Li Xin Hou, Kunpeng Cui, Miao Du, Qiang Zheng, Zi Liang Wu. (2023) Formation and Destruction of Polyelectrolyte/Surfactant Complexes for the Toughening of Hydrogels. MACROMOLECULES, 56 (21): (8887–8898). [PMID:24874740] |
2. Wei Wang, Zhensheng Shen, Jiaxiang Zhang, Lun Pan, Chengxiang Shi, Xiangwen Zhang, Ji-Jun Zou. (2024) Synthesis and Performance of Cyclopentadiene-Based Spirocyclopropane High-Energy-Density Fuels. FUEL, 355 (129380). [PMID:] |
3. Yaqin Liang, Hui Li, Jiahui Ji, Jiayu Wang, Yujie Ji. (2023) Self-Aggregation, Antimicrobial Activity and Cytotoxicity of Ester-Bonded Gemini Quaternary Ammonium Salts: The Role of the Spacer. MOLECULES, 28 (14): (5469). [PMID:37513340] |
4. Chenqi Zhang, Xinshuang Gao, Hanbo Li, Yinglu Ji, Rui Cai, Zhijian Hu, Xiaochun Wu. (2023) Regulation of Chirality Transfer and Amplification from Chiral Cysteine to Gold Nanorod Assemblies using Nonchiral Surface Ligands. Advanced Optical Materials, 11 (18): (2202804). [PMID:] |
5. Zhong Yuan, Zhang Jiangwei, Li Tingting, Xu Wenwu, Yao Qiaofeng, Lu Min, Bai Xue, Wu Zhennan, Xie Jianping, Zhang Yu. (2023) Suppression of kernel vibrations by layer-by-layer ligand engineering boosts photoluminescence efficiency of gold nanoclusters. Nature Communications, 14 (1): (1-12). [PMID:36746958] |
6. Yaqi Li, Yongjian Cao, Silong Wu, Yuanlai Ju, Xiaohua Zhang, Canhui Lu, Wei Sun. (2023) Manipulative pore-formation of polyimide film for tuning the dielectric property via breath figure method. POLYMER, 269 (125731). [PMID:] |
7. Xiaoqing Xiong, Ye Yuan, Gengwen Chen, Miao Li, Lihua Lyu, Hongjuan Zhao, Jun Yan, Yulan Qian, Junyang Zhu, Chengqi Jiao. (2023) Construction, photophysical properties, structure-activity relationship, and applications of fluorescein analogs. DYES AND PIGMENTS, 208 (110870). [PMID:] |
8. Yangzheng Huang, Shao-Lu Li, Zhenxing Fu, Genghao Gong, Yunxia Hu. (2022) Preparation of microporous organic solvent nanofiltration (OSN) composite membrane from a novel tris-phenol monomer. SEPARATION AND PURIFICATION TECHNOLOGY, 301 (121985). [PMID:] |
9. Tao Wen, Jielin Luo, Kai Jiao, Lin Lu. (2022) Comparison of pool boiling heat transfer performance between aqueous cationic and anionic surfactant solutions with similar ionic group. APPLIED THERMAL ENGINEERING, 216 (119136). [PMID:] |
10. Ya-Ling Yu, Min-Zhen Shi, Si-Chen Zhu, Jun Cao. (2022) The two-phase amphiphilic preconcentration based on surfactants to enrich phenolic compounds from diluted plant extracts and rat urine by micellar electrokinetic chromatography. ELECTROPHORESIS, 43 (16-17): (1735-1745). [PMID:35751616] |
11. Shuai Zheng, Lei Jiang, Changqi Zhang, Ning Ma, Xueqiang Liu. (2022) Facile and environment-friendly preparation of high-performance polyimide aerogels using water as the only solvent. Polymer Chemistry, 13 (16): (2375-2382). [PMID:] |
12. Chaomeng Dai, Wang Kai Tong, Jia Jie Zou, Min-tian Gao, Yalei Zhang, Shuguang Liu, Tingzhu Li, Jixiang Li, Jiajun Hu. (2022) Synergistic solubilization of phenanthrene using micro-nanobubbles and cationic surfactants: Universal verifying, amplifying, and strengthening the synergy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 644 (128837). [PMID:] |
13. Wennan Xu, Yuxin Li, Xin Liu, Yining Zhao, Rui Li, Rui Li, Hongliang Li. (2022) How does coal interact with organic groups in an aqueous solution?. FUEL, 316 (123295). [PMID:] |
14. Zeng Nengyuan, Zhao Hongdong, Liu Yuling, Wang Chenwei, Luo Chong, Wang Wantang, Ma Tengda. (2022) Optimizing of the Colloidal Dispersity of Silica Nanoparticle Slurries for Chemical Mechanical Polishing. Silicon, 14 (13): (7473-7481). [PMID:] |
15. Yanjuan Yang,Lifei Liu,Xin Huang,Xiuniang Tan,Tian Luo,Wei Li. (2015-09-24) Temperature-induced vesicle to micelle transition in cationic/cationic mixed surfactant systems.. Soft matter, 11 ((45)): (8848-8855). [PMID:26395000] |
1. Ramkrishna Adhikary,Philip J Carlson,Tak W Kee,Jacob W Petrich. (2010-02-09) Excited-state intramolecular hydrogen atom transfer of curcumin in surfactant micelles.. The journal of physical chemistry. B, 114 ((8)): (2997-3004). [PMID:20136104] |
2. Yali Wang,Jinyue Wu,Xuejiao Ru,Yucheng Jiang,Mancheng Hu,Shuni Li,Quanguo Zhai. (2010-08-31) Catalytic performance and thermostability of chloroperoxidase in reverse micelle: achievement of a catalytically favorable enzyme conformation.. Journal of industrial microbiology & biotechnology, 38 ((6)): (717-724). [PMID:20803346] |
3. Monica A James-Smith,Brittney Hellner,Nancy Annunziato,Samir Mitragotri. (2010-11-11) Effect of surfactant mixtures on skin structure and barrier properties.. Annals of biomedical engineering, 39 ((4)): (1215-1223). [PMID:21063778] |
4. Shi-Yong Ran,Yan-Wei Wang,Guang-Can Yang,Lin-Xi Zhang. (2011-04-08) Morphology characterization and single-molecule study of DNA-dodecyltrimethylammonium bromide complex.. The journal of physical chemistry. B, 115 ((16)): (4568-4575). [PMID:21469675] |
5. Marcos A Villetti,Clara I D Bica,Irene T S Garcia,Fabiano V Pereira,Francieli I Ziembowicz,Carmen L Kloster,Cristiano Giacomelli. (2011-04-27) Physicochemical properties of methylcellulose and dodecyltrimethylammonium bromide in aqueous medium.. The journal of physical chemistry. B, 115 ((19)): (5868-5876). [PMID:21517042] |
6. A A Mikhailovskaya,B A Noskov,S-Y Lin,G Loglio,R Miller. (2011-07-26) Formation of protein/surfactant adsorption layer at the air/water interface as studied by dilational surface rheology.. The journal of physical chemistry. B, 115 ((33)): (9971-9979). [PMID:21780823] |
7. Gehad G Mohamed,Tamer Awad Ali,M F El-Shahat,M A Migahed,A M Al-Sabagh. (2011-10-15) Novel screen-printed electrode for the determination of dodecyltrimethylammonium bromide in water samples.. Drug testing and analysis, 4 ((12)): (1009-1013). [PMID:21998089] |
8. Dan Ke,Xiaoyong Wang,Qianqian Yang,Yumeng Niu,Shaohu Chai,Zhiyun Chen,Xueqin An,Weiguo Shen. (2011-10-19) Spectrometric study on the interaction of dodecyltrimethylammonium bromide with curcumin.. Langmuir : the ACS journal of surfaces and colloids, 27 ((23)): (14112-14117). [PMID:22004075] |
9. Chong Zhang,Feng-Yi Su,Jian-Feng Zhang,Sang-Tian Yan,Xin-Hui Xing. (2011-11-15) Luciferase and fluorescent protein as dual reporters analyzing the effect of n-dodecyltrimethylammonium bromide on the physiology of Pseudomonas putida.. Applied microbiology and biotechnology, 93 ((1)): (393-400). [PMID:22075632] |
10. Masahiko Annaka. (2011-12-27) Salt effect on microscopic structure and stability of colloidal complex obtained from neutral/polyelectrolyte block copolymer and oppositely charged surfactant.. Colloids and surfaces. B, Biointerfaces, 99 (127-135). [PMID:22197735] |
11. Hiromasa Uchiyama,Yuichi Tozuka,Masahiro Nishikawa,Hirofumi Takeuchi. (2012-01-24) Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug.. International journal of pharmaceutics, 428 ((1-2)): (183-186). [PMID:22265914] |
12. I Echavarri Franco,P Lorchat,J-P Lamps,M Schmutz,A Schröder,J-M Catala,J Combet,F Schosseler. (2012-02-16) From chain collapse to new structures: spectroscopic properties of poly(3-thiophene acetic acid) upon binding by alkyl trimethylammonium bromide surfactants.. Langmuir : the ACS journal of surfaces and colloids, 28 ((10)): (4815-4828). [PMID:22332777] |
13. A R Tehrani-Bagha,R G Singh,K Holmberg. (2012-03-27) Solubilization of two organic dyes by cationic ester-containing gemini surfactants.. Journal of colloid and interface science, 376 ((1)): (112-118). [PMID:22444485] |
14. Katarzyna Zielińska,Alicja Stankiewicz,Irena Szczygieł. (2012-04-14) Electroless deposition of Ni-P-nano-ZrO2 composite coatings in the presence of various types of surfactants.. Journal of colloid and interface science, 377 ((1)): (362-367). [PMID:22498365] |
15. Salil Kumar Bhowmik,Byung Hwa Jung. (2012-05-18) Analysis of plasma nucleotides in rat by micellar electrokinetic capillary chromatography/electrospray ionization mass spectrometry.. Rapid communications in mass spectrometry : RCM, 26 ((12)): (1426-1436). [PMID:22592986] |
16. Raquel F Correia,Maria Isabel Viseu,Telmo J V Prazeres,José M G Martinho. (2012-05-23) Spontaneous vesicles, disks, threadlike and spherical micelles found in the solubilization of DMPC liposomes by the detergent DTAC.. Journal of colloid and interface science, 379 ((1)): (56-63). [PMID:22608143] |
17. Jonas Carlstedt,Azat Bilalov,Ulf Olsson. (2012-06-14) Aqueous phase behavior of polyelectrolytes with amphiphilic counterions modulated by cyclodextrin: the role of polyion flexibility.. Physical chemistry chemical physics : PCCP, 14 ((27)): (9574-9577). [PMID:22691921] |
18. Ketsarin Seebunrueng,Yanawath Santaladchaiyakit,Supalax Srijaranai. (2012-07-05) Study on the effect of chain-length compatibility of mixed anionic-cationic surfactants on the cloud-point extraction of selected organophosphorus pesticides.. Analytical and bioanalytical chemistry, 404 ((5)): (1539-1548). [PMID:22760506] |
19. Sriram Sokalingam,Govindan Raghunathan,Nagasundarapandian Soundrarajan,Sun-Gu Lee. (2012-07-14) A study on the effect of surface lysine to arginine mutagenesis on protein stability and structure using green fluorescent protein.. PloS one, 7 ((7)): (e40410-e40410). [PMID:22792305] |
20. Ye Liu,Daming Cheng,I-Hsin Lin,Nicholas L Abbott,Hongrui Jiang. (2012-07-31) Microfluidic sensing devices employing in situ-formed liquid crystal thin film for detection of biochemical interactions.. Lab on a chip, 12 ((19)): (3746-3753). [PMID:22842797] |
21. Deping Huang,Yuanyuan Qi,Xiangtao Bai,Lijuan Shi,Han Jia,Dongju Zhang,Liqiang Zheng. (2012-08-11) One-pot synthesis of dendritic gold nanostructures in aqueous solutions of quaternary ammonium cationic surfactants: effects of the head group and hydrocarbon chain length.. ACS applied materials & interfaces, 4 ((9)): (4665-4671). [PMID:22877504] |
22. Shohreh Ariaeenejad,Mehran Habibi-Rezaei,Kaveh Kavousi,Shahla Jamili,Mohammad Reza Fatemi,Jun Hong,Najmeh Poursasan,Nader Sheibani,Ali A Moosavi-Movahedi. (2012-11-13) Denaturation and intermediates study of two sturgeon hemoglobins by n-dodecyl trimethylammonium bromide.. International journal of biological macromolecules, 53 (107-113). [PMID:23142155] |
23. Shaoxin Feng,Paul M Bummer. (2012-11-16) Competition of hydrophobic steroids with sodium dodecyl sulfate, dodecyltrimethylammonium bromide, or dodecyl β-D-maltoside for the dodecane/water interface.. Langmuir : the ACS journal of surfaces and colloids, 28 ((49)): (16927-16932). [PMID:23151278] |
24. Marta Baptista,Stephen J Publicover,João Ramalho-Santos. (2012-12-12) In vitro effects of cationic compounds on functional human sperm parameters.. Fertility and sterility, 99 ((3)): (705-712). [PMID:23218922] |
25. Yuri Park,Godwin A Ayoko,Róbert Kurdi,Erzsébet Horváth,Janos Kristóf,Ray L Frost. (2013-06-25) Adsorption of phenolic compounds by organoclays: implications for the removal of organic pollutants from aqueous media.. Journal of colloid and interface science, 406 (196-208). [PMID:23791228] |
26. Sara G Hovakeemian,Runhui Liu,Samuel H Gellman,Heiko Heerklotz. (2015-08-04) Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents.. Soft matter, 11 ((34)): (6840-6851). [PMID:26234884] |
27. Jing Shang,Pavel Zrazhevskiy,Nadia Postupna,C Dirk Keene,Thomas J Montine,Xiaohu Gao. (2015-09-04) Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling.. Scientific reports, 5 (13651-13651). [PMID:26328896] |
28. Johannes Weirather,Ulrich D W Hofmann,Niklas Beyersdorf,Gustavo C Ramos,Benjamin Vogel,Anna Frey,Georg Ertl,Thomas Kerkau,Stefan Frantz. (2014-05-03) Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.. Circulation research, 115 ((1)): (55-67). [PMID:24786398] |
29. Hao Nan Qiu, Xing Peng Hao, Li Xin Hou, Kunpeng Cui, Miao Du, Qiang Zheng, Zi Liang Wu. (2023) Formation and Destruction of Polyelectrolyte/Surfactant Complexes for the Toughening of Hydrogels. MACROMOLECULES, 56 (21): (8887–8898). [PMID:24874740] |
30. Wei Wang, Zhensheng Shen, Jiaxiang Zhang, Lun Pan, Chengxiang Shi, Xiangwen Zhang, Ji-Jun Zou. (2024) Synthesis and Performance of Cyclopentadiene-Based Spirocyclopropane High-Energy-Density Fuels. FUEL, 355 (129380). [PMID:] |
31. Yaqin Liang, Hui Li, Jiahui Ji, Jiayu Wang, Yujie Ji. (2023) Self-Aggregation, Antimicrobial Activity and Cytotoxicity of Ester-Bonded Gemini Quaternary Ammonium Salts: The Role of the Spacer. MOLECULES, 28 (14): (5469). [PMID:37513340] |
32. Chenqi Zhang, Xinshuang Gao, Hanbo Li, Yinglu Ji, Rui Cai, Zhijian Hu, Xiaochun Wu. (2023) Regulation of Chirality Transfer and Amplification from Chiral Cysteine to Gold Nanorod Assemblies using Nonchiral Surface Ligands. Advanced Optical Materials, 11 (18): (2202804). [PMID:] |
33. Zhong Yuan, Zhang Jiangwei, Li Tingting, Xu Wenwu, Yao Qiaofeng, Lu Min, Bai Xue, Wu Zhennan, Xie Jianping, Zhang Yu. (2023) Suppression of kernel vibrations by layer-by-layer ligand engineering boosts photoluminescence efficiency of gold nanoclusters. Nature Communications, 14 (1): (1-12). [PMID:36746958] |
34. Yaqi Li, Yongjian Cao, Silong Wu, Yuanlai Ju, Xiaohua Zhang, Canhui Lu, Wei Sun. (2023) Manipulative pore-formation of polyimide film for tuning the dielectric property via breath figure method. POLYMER, 269 (125731). [PMID:] |
35. Xiaoqing Xiong, Ye Yuan, Gengwen Chen, Miao Li, Lihua Lyu, Hongjuan Zhao, Jun Yan, Yulan Qian, Junyang Zhu, Chengqi Jiao. (2023) Construction, photophysical properties, structure-activity relationship, and applications of fluorescein analogs. DYES AND PIGMENTS, 208 (110870). [PMID:] |
36. Yangzheng Huang, Shao-Lu Li, Zhenxing Fu, Genghao Gong, Yunxia Hu. (2022) Preparation of microporous organic solvent nanofiltration (OSN) composite membrane from a novel tris-phenol monomer. SEPARATION AND PURIFICATION TECHNOLOGY, 301 (121985). [PMID:] |
37. Tao Wen, Jielin Luo, Kai Jiao, Lin Lu. (2022) Comparison of pool boiling heat transfer performance between aqueous cationic and anionic surfactant solutions with similar ionic group. APPLIED THERMAL ENGINEERING, 216 (119136). [PMID:] |
38. Ya-Ling Yu, Min-Zhen Shi, Si-Chen Zhu, Jun Cao. (2022) The two-phase amphiphilic preconcentration based on surfactants to enrich phenolic compounds from diluted plant extracts and rat urine by micellar electrokinetic chromatography. ELECTROPHORESIS, 43 (16-17): (1735-1745). [PMID:35751616] |
39. Shuai Zheng, Lei Jiang, Changqi Zhang, Ning Ma, Xueqiang Liu. (2022) Facile and environment-friendly preparation of high-performance polyimide aerogels using water as the only solvent. Polymer Chemistry, 13 (16): (2375-2382). [PMID:] |
40. Chaomeng Dai, Wang Kai Tong, Jia Jie Zou, Min-tian Gao, Yalei Zhang, Shuguang Liu, Tingzhu Li, Jixiang Li, Jiajun Hu. (2022) Synergistic solubilization of phenanthrene using micro-nanobubbles and cationic surfactants: Universal verifying, amplifying, and strengthening the synergy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 644 (128837). [PMID:] |
41. Wennan Xu, Yuxin Li, Xin Liu, Yining Zhao, Rui Li, Rui Li, Hongliang Li. (2022) How does coal interact with organic groups in an aqueous solution?. FUEL, 316 (123295). [PMID:] |
42. Zeng Nengyuan, Zhao Hongdong, Liu Yuling, Wang Chenwei, Luo Chong, Wang Wantang, Ma Tengda. (2022) Optimizing of the Colloidal Dispersity of Silica Nanoparticle Slurries for Chemical Mechanical Polishing. Silicon, 14 (13): (7473-7481). [PMID:] |
43. Yanjuan Yang,Lifei Liu,Xin Huang,Xiuniang Tan,Tian Luo,Wei Li. (2015-09-24) Temperature-induced vesicle to micelle transition in cationic/cationic mixed surfactant systems.. Soft matter, 11 ((45)): (8848-8855). [PMID:26395000] |