Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129751-10mg | 10mg | In stock | $77.90 | |
D129751-50mg | 50mg | In stock | $288.90 | |
D129751-250mg | 250mg | In stock | $1,300.90 |
Antiarrhythmic agent. Potent and selective hERG K + channel blocker
Synonyms | 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino] ethane | DTXSID5046433 | SCHEMBL16135 | SMR000466333 | CHEBI:50217 | NCGC00024585-01 | UK68798 | UK-68798 | 2,6-Bis(3,4-(methylenedioxy)phenyl)-3,7-dioxabicyclo(3.3.0)oc |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Dofetilide is a potassium channel blocker.Potent and selective hERG K + channel blocker. Selectively blocks the rapid component of the delayed rectifier outward potassium current. Class III antiarrhythmic agent. Increases the atrial refractory period in v |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | BLOCKER, CHANNEL BLOCKER |
Mechanism of action | HERG blocker |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A potassium channel blocker. |
ALogP | 1.8 |
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IUPAC Name | N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide |
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INCHI | InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 |
InChi Key | IXTMWRCNAAVVAI-UHFFFAOYSA-N |
Canonical SMILES | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
Isomeric SMILES | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
WGK Germany | 3 |
PubChem CID | 71329 |
Molecular Weight | 441.56 |
PubChem CID | 71329 |
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DrugBank Ligand | DB00204 |
CAS Registry No. | 115256-11-6 |
ChEBI | CHEBI:4681 |
ChEMBL Ligand | CHEMBL473 |
BindingDB Ligand | 50031720 |
Wikipedia | Dofetilide |
DrugCentral Ligand | 942 |
Enter Lot Number to search for COA:
Solubility | Soluble in DMSO (>20 mg/ml), acetone, alcohol (slightly), and methanol |
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Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H360:May damage fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |