Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129436-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $24.90 | |
D129436-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $82.90 | |
D129436-1g | 1g | In stock | $230.90 | |
D129436-5g | 5g | In stock | $686.90 | |
D129436-25g | 25g | In stock | $2,059.90 | |
D129436-100g | 100g | In stock | $2,574.90 | |
D129436-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $3,089.90 |
Peripheral D 2 -like receptor antagonist
Synonyms | DOMPERIDONE [INN] | HMS3656M21 | KBioGR_000354 | MLS000859942 | SCHEMBL43729 | 5587267Z69 | HMS3261E16 | NSC 299589 | DTXCID9025116 | NSC299589 | NSC-299589 | HMS2089C14 | NCIStruc2_001819 | Spectrum4_000087 | 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Domperidone is a selective inhibitor of the peripheral D2DR. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.Peripheral D 2 -like receptor antagonist. Does not readily cross the blood-brain barrie |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Dopamine D2 receptor antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Domperidone is a dopamine blocker and an antidopaminergic reagent |
ALogP | 3.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
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INCHI | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
InChi Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O |
Isomeric SMILES | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O |
WGK Germany | 3 |
RTECS | DE2275900 |
PubChem CID | 3151 |
Molecular Weight | 425.91 |
PubChem CID | 3151 |
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DrugBank Ligand | DB01184 |
CAS Registry No. | 57808-66-9 |
ChEBI | CHEBI:464745 |
ChEMBL Ligand | CHEMBL219916 |
BindingDB Ligand | 50241107 |
Wikipedia | Domperidone |
PEP | domperidone |
DrugCentral Ligand | 945 |
GPCRdb Ligand | domperidone |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2228034 | Certificate of Analysis | Feb 20, 2024 | D129436 |
D2228056 | Certificate of Analysis | Feb 20, 2024 | D129436 |
F2125240 | Certificate of Analysis | Apr 13, 2023 | D129436 |
F2125241 | Certificate of Analysis | Apr 13, 2023 | D129436 |
F1509071 | Certificate of Analysis | Jan 16, 2023 | D129436 |
C1926065 | Certificate of Analysis | Nov 10, 2022 | D129436 |
Solubility | DMSO 48 mg/mL Water <1 mg/mL Ethanol 1 mg/mL |
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Melt Point(°C) | 243°C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | DE2275900 |
Merck Index | 3418 |
1. Yanxia Liu, Xiuquan Yao, Chunlin Liu, Xiaofang Luo, Chao Guo, Wei Du. (2022) The Drug Domperidone as a Corrosion Inhibitor for X60 Steel in Hydrochloric Acid Solution. International Journal of Electrochemical Science, 17 (220445). [PMID:] [10.20964/2022.04.55] |
2. Yang Zhou, Lei Guo, Zhiheng Zhao, Sisi Zheng, Yue Xu, Bin Xiang, Savaş Kaya. (2018) Anticorrosion potential of domperidone on copper in different concentration of hydrochloric acid solution. JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01694243.2018.1426542] |
1. Romanò N et al.. (2013) Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release.. J Neurosci, 33 (10): (4424-33). [PMID:23467359] |
2. Yanxia Liu, Xiuquan Yao, Chunlin Liu, Xiaofang Luo, Chao Guo, Wei Du. (2022) The Drug Domperidone as a Corrosion Inhibitor for X60 Steel in Hydrochloric Acid Solution. International Journal of Electrochemical Science, 17 (220445). [PMID:] [10.20964/2022.04.55] |
3. Yang Zhou, Lei Guo, Zhiheng Zhao, Sisi Zheng, Yue Xu, Bin Xiang, Savaş Kaya. (2018) Anticorrosion potential of domperidone on copper in different concentration of hydrochloric acid solution. JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01694243.2018.1426542] |