donecopride , CAS No.D609947, Agonist of 5-HT 4 receptor;Inhibitor of acetylcholinesterase (Cartwright blood group)

Item Number
D609947
Grouped product items
SKUSizeAvailabilityPrice Qty
D609947-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609947-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST, INHIBITOR
Mechanism of actionAgonist of 5-HT 4 receptor;Inhibitor of acetylcholinesterase (Cartwright blood group)

Associated Targets(Human)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR4 Tclin 5-hydroxytryptamine receptor 4 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-(cyclohexylmethyl)piperidin-4-yl]propan-1-one
INCHI InChI=1S/C22H33ClN2O2/c1-27-22-14-20(24)19(23)13-18(22)21(26)8-7-16-9-11-25(12-10-16)15-17-5-3-2-4-6-17/h13-14,16-17H,2-12,15,24H2,1H3
InChi Key FTRZTHFGTILUPE-UHFFFAOYSA-N
Canonical SMILES COc1cc(N)c(cc1C(=O)CCC1CCN(CC1)CC1CCCCC1)Cl
Isomeric SMILES COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CC3CCCCC3)Cl)N
PubChem CID 86582973

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A et al..  (2014)  Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment..  Proc Natl Acad Sci USA,  111  (36): (E3825-30).  [PMID:25157130] [10.1021/op500134e]
2. Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T et al..  (2015)  Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride..  J Med Chem,  58  (7): (3172-87).  [PMID:25793650] [10.1021/op500134e]
3. Rochais C, Lecoutey C, Hamidouche K, Giannoni P, Gaven F, Cem E, Mignani S, Baranger K, Freret T, Bockaert J et al..  (2020)  Donecopride, a Swiss army knife with potential against Alzheimer's disease..  Br J Pharmacol,  177  (9): (1988-2005).  [PMID:31881553] [10.1021/op500134e]
4. Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD.  (1995)  Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo..  Br J Pharmacol,  115  (8): (1387-92).  [PMID:8564196] [10.1021/op500134e]

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