Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129948-250mg | 250mg | In stock | $31.90 | |
D129948-1g | 1g | In stock | $97.90 | |
D129948-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $295.90 | |
D129948-25g | 25g | In stock | $1,329.90 | |
D129948-100g | 100g | In stock | $4,786.90 |
Acetylcholinesterase inhibitor
Synonyms | Donepezil hydrochloride|120011-70-3|Donepezil HCl|Aricept|BNAG|110119-84-1|2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride|Aricept ODT|E-2020|E 2020|E 2020 (pharmaceutical)|ADLARITY|E2020|Donepezil (Hydrochloride) |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain aga |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Acetylcholinesterase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
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IUPAC Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride |
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INCHI | InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H |
InChi Key | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl |
Isomeric SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl |
WGK Germany | 1 |
RTECS | NK8927885 |
Alternate CAS | 110119-84-1 |
PubChem CID | 5741 |
Molecular Weight | 415.96 |
Reaxy-Rn | 7062905 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2412034 | Certificate of Analysis | Sep 15, 2023 | D129948 |
K2119224 | Certificate of Analysis | Sep 15, 2023 | D129948 |
K2119226 | Certificate of Analysis | Sep 15, 2023 | D129948 |
K2119303 | Certificate of Analysis | Sep 15, 2023 | D129948 |
K2119304 | Certificate of Analysis | Sep 15, 2023 | D129948 |
K2116046 | Certificate of Analysis | Sep 13, 2023 | D129948 |
K2115202 | Certificate of Analysis | Aug 21, 2023 | D129948 |
K1709045 | Certificate of Analysis | May 10, 2023 | D129948 |
A2125505 | Certificate of Analysis | Nov 16, 2022 | D129948 |
D2313819 | Certificate of Analysis | Nov 04, 2021 | D129948 |
D2412033 | Certificate of Analysis | Nov 04, 2021 | D129948 |
K2301067 | Certificate of Analysis | Nov 04, 2021 | D129948 |
Solubility | Soluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly). |
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Sensitivity | Moisture sensitive |
Melt Point(°C) | 220-222°C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H301:Toxic if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 1 |
RTECS | NK8927885 |
Reaxy-Rn | 7062905 |
Merck Index | 3419 |