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Donepezil HCl - ≥98%, high purity , Acetylcholinesterase inhibitor, CAS No.120011-70-3, Acetylcholinesterase inhibitor

  • ≥98%
Item Number
D129948
Grouped product items
SKUSizeAvailabilityPrice Qty
D129948-250mg
250mg
In stock
$31.90
D129948-1g
1g
In stock
$97.90
D129948-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$295.90
D129948-25g
25g
In stock
$1,329.90
D129948-100g
100g
In stock
$4,786.90

Acetylcholinesterase inhibitor

Basic Description

SynonymsDonepezil hydrochloride|120011-70-3|Donepezil HCl|Aricept|BNAG|110119-84-1|2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride|Aricept ODT|E-2020|E 2020|E 2020 (pharmaceutical)|ADLARITY|E2020|Donepezil (Hydrochloride)
Specifications & Purity≥98%
Biochemical and Physiological MechanismsDonepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain aga
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypeINHIBITOR
Mechanism of actionAcetylcholinesterase inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
A noncompetitive acetylcholinesterase (AChE) inhibitor.

Associated Targets

PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
INCHI InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChi Key XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Canonical SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
Isomeric SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
WGK Germany 1
RTECS NK8927885
Alternate CAS 110119-84-1
PubChem CID 5741
Molecular Weight 415.96
Reaxy-Rn 7062905

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot NumberCertificate TypeDateItem
D2412034Certificate of AnalysisSep 15, 2023 D129948
K2119224Certificate of AnalysisSep 15, 2023 D129948
K2119226Certificate of AnalysisSep 15, 2023 D129948
K2119303Certificate of AnalysisSep 15, 2023 D129948
K2119304Certificate of AnalysisSep 15, 2023 D129948
K2116046Certificate of AnalysisSep 13, 2023 D129948
K2115202Certificate of AnalysisAug 21, 2023 D129948
K1709045Certificate of AnalysisMay 10, 2023 D129948
A2125505Certificate of AnalysisNov 16, 2022 D129948
D2313819Certificate of AnalysisNov 04, 2021 D129948
D2412033Certificate of AnalysisNov 04, 2021 D129948
K2301067Certificate of AnalysisNov 04, 2021 D129948

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Chemical and Physical Properties

SolubilitySoluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly).
SensitivityMoisture sensitive
Melt Point(°C)220-222°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H319:Causes serious eye irritation

H301:Toxic if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

WGK Germany 1
RTECS NK8927885
Reaxy-Rn 7062905
Merck Index 3419

Related Documents

Solution Calculators