Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain aga
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Action Type
INHIBITOR
Mechanism of action
Acetylcholinesterase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. A noncompetitive acetylcholinesterase (AChE) inhibitor.
1.Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12):(116013). [PMID:38052155]
2.Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu. (2023) Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, (15):(115765). [PMID:37844366]
3.Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han. (2022) Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY, 292 (115194). [PMID:35304276]
4.Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis. Frontiers in Aging Neuroscience, 13 (942). [PMID:35126093]
5.Wu M, Ma J, Ji L, Wang M, Han J, Li Z.. (2019) Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 177 (198-211). [PMID:31136894]
References
1.Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12):(116013). [PMID:38052155]
2.Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu. (2023) Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, (15):(115765). [PMID:37844366]
3.Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han. (2022) Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY, 292 (115194). [PMID:35304276]
4.Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis. Frontiers in Aging Neuroscience, 13 (942). [PMID:35126093]
5.Wu M, Ma J, Ji L, Wang M, Han J, Li Z.. (2019) Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 177 (198-211). [PMID:31136894]
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