Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D101734-25mg | 25mg | In stock | $65.90 | |
D101734-100mg | 100mg | In stock | $218.90 | |
D101734-1g | 1g | In stock | $1,971.90 |
Synonyms | donepezil | 120014-06-4 | Aricept | 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one | donepezilo | Donaz | donepezilum | Domepezil | HSDB 7743 | 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one | 2-[(1-benzylpiperidin-4-yl)met |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of acetylcholinesterase (Cartwright blood group) |
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Pubchem Sid | 488179748 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179748 |
IUPAC Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one |
INCHI | InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 |
InChi Key | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC |
Isomeric SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC |
WGK Germany | 3 |
PubChem CID | 3152 |
Molecular Weight | 433.97 |
DrugBank Ligand | DB00843 |
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CAS Registry No. | 120014-06-4 |
PubChem CID | 3152 |
ChEMBL Ligand | CHEMBL502 |
Wikipedia | Donepezil |
PEP | donepezil |
Reactome Reaction | R-HSA-9634834 |
Reactome Drug | R-ALL-9635088 |
DrugCentral Ligand | 946 |
PubChem SID | 488179748 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2014117 | Certificate of Analysis | Apr 07, 2024 | D101734 |
G2014115 | Certificate of Analysis | Apr 07, 2024 | D101734 |
G2014116 | Certificate of Analysis | Apr 07, 2024 | D101734 |
F2314195 | Certificate of Analysis | Jun 20, 2023 | D101734 |
A2303317 | Certificate of Analysis | Jan 07, 2023 | D101734 |
Flash Point(°F) | 49 °C |
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Flash Point(°C) | 49°C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H300:Fatal if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388] |
1. Luo W, Yu QS, Kulkarni SS, Parrish DA, Holloway HW, Tweedie D, Shafferman A, Lahiri DK, Brossi A, Greig NH. (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.. J Med Chem, 49 (7): (2174-85). [PMID:16570913] |
2. Sabbagh M, Cummings J, Christensen D, Doody R, Farlow M, Liu L, Mackell J, Fain R. (2013) Evaluating the cognitive effects of donepezil 23 mg/d in moderate and severe Alzheimer's disease: analysis of effects of baseline features on treatment response.. BMC Geriatr, 13 (3): (56). [PMID:23742728] |
3. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang. (2022) Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease. Neuropsychiatric Disease and Treatment, [PMID:33061388] |