Dorsomorphin - ≥98%, high purity , CAS No.866405-64-3, Inhibitor of EPH receptor A2;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of kinase insert domain receptor;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of MAPK i

Item Number

D139352

• Synonyms: dorsomorphin|866405-64-3|6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine|BML-275|Compound C|AMPK Inhibitor, Compound C|6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine|Dorsomorphin free base|866
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomo
• Storage Temp: Store at 2-8°C,Protected from light,Argon charged
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of EPH receptor A2;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of kinase insert domain receptor;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of MAPK i
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Please note that sonication\xa0in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.

Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)。