Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
D139352-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $46.90 | |
D139352-25mg | 25mg | In stock | $152.90 | |
D139352-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $426.90 |
Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
Synonyms | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine | AC-27419 | SY256013 | AM20061004 | Dorsomorphin, >=98% (HPLC) | NCGC00165869-01 | 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | HMS2852B03 | U |
---|---|
Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. Dorsomo |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of EPH receptor A2;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of kinase insert domain receptor;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of MAPK i |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Please note that sonication\xa0in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin. Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599)。 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
---|---|
INCHI | InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
InChi Key | XHBVYDAKJHETMP-UHFFFAOYSA-N |
Canonical SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 |
Isomeric SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 |
WGK Germany | 3 |
PubChem CID | 11524144 |
Molecular Weight | 399.49 |
CAS Registry No. | 866405-64-3 |
---|---|
PubChem CID | 11524144 |
ChEMBL Ligand | CHEMBL478629 |
RCSB PDB Ligand | TAK |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2404839 | Certificate of Analysis | Nov 25, 2023 | D139352 |
A2404840 | Certificate of Analysis | Nov 25, 2023 | D139352 |
A2404841 | Certificate of Analysis | Nov 25, 2023 | D139352 |
K2116143 | Certificate of Analysis | Sep 13, 2023 | D139352 |
K2315087 | Certificate of Analysis | Sep 13, 2023 | D139352 |
F1503029 | Certificate of Analysis | Jan 19, 2023 | D139352 |
D2328009 | Certificate of Analysis | Nov 22, 2021 | D139352 |
Solubility | Soluble in DMSO (4 mg/ml warm), 100 mM HCl, and MeOH. |
---|---|
Sensitivity | air & light & heat sensitive |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. |
WGK Germany | 3 |
Starting at $127.90
1. Chao Tian, Yuchao Feng, Tianhua Chen, Zuyang Zhang, Xiaojie He, Liangdong Jiang, Mingjiang Liu. (2023) EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK/ULK1 Pathway. Frontiers in Bioscience-Landmark, 28 (12): (324). [PMID:38179734] |
2. Xuan Ren, Jianchun Xu, Qingsong Xue, Yi Tong, Tairan Xu, Jinli Wang, Ting Yang, Yuan Chen, Deshun Shi, Xiangping Li. (2024) BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways. THERIOGENOLOGY, 215 (22): (10). [PMID:38000125] |
3. Yixin Sun, Danyang Guo, Saiding Yue, Mingyan Zhou, Dongxu Wang, Fengjiao Chen, Lingling Wang. (2023) Afzelin protects against doxorubicin-induced cardiotoxicity by promoting the AMPKα/SIRT1 signaling pathway. TOXICOLOGY AND APPLIED PHARMACOLOGY, (17): (116687). [PMID:37703929] |
4. Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Lee. (2023) Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. CNS Neuroscience & Therapeutics, [PMID:37641913] |
5. Xingru Chen, Xiaolan Zhou, Xiaoqing Cheng, Liting Lin, Qi Wang, Ruoting Zhan, Qingguang Wu, Sijun Liu. (2023) Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. MOLECULES, 28 (8): (3482). [PMID:37110714] |
6. Haixu Wang, Yan Li, Chuang Liu, Tianxiang Lu, Qian Zhai, Hongna Wang, Jianfang Zhang. (2023) Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway. JOURNAL OF TOXICOLOGICAL SCIENCES, [PMID:36858637] |
7. Xing Zhang, Zhang-Tao Hu, Yu Li, Yan-Xue Li, Ming Xian, Song-Mao Guo, Jian-Hong Hu. (2022) Effect of Astragalus polysaccharides on the cryopreservation of goat semen. THERIOGENOLOGY, 193 (47). [PMID:36156425] |
8. Jiaqiao Li, Yameng Fan, Yan Zhang, Yamei Liu, Yan Yu, Mao Ma. (2022) Resveratrol Induces Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Cells by Activating the NGFR-AMPK-mTOR Pathway. Nutrients, 14 (12): (2413). [PMID:35745143] |
9. Xixi Song, Minghui Wang, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin. (2022) Ghrelin is a signal to facilitate the utilization of fatty acids and save glucose by the liver, skeletal muscle, and adipose tissues in chicks. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1867 (159081). [PMID:34856413] |
10. Tian-Yu Feng, Dong-Liang Lv, Xing Zhang, Ye-Qing Du, Yi-Tian Yuan, Mei-Jie Chen, Hua-Ming Xi, Yu Li, Ning Han, Jian-Hong Hu. (2020) Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation. REPRODUCTION IN DOMESTIC ANIMALS, 55 (12): (1714-1724). [PMID:32969084] |
11. Shanshan Wang, Qian Luo, Yuefang Zhou, Peihong Fan. (2019) CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways. ACS Omega, 4 (15): (16517–16523). [PMID:31616830] |
1. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N et al.. (2001) Role of AMP-activated protein kinase in mechanism of metformin action.. J Clin Invest, 108 (8): (1167-74). [PMID:11602624] |
2. Song SB & Hwang ES. (2018) A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1.. Cells, 8 [PMID:30591661] |
3. Kundu A et al.. (2020) 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.. J Biol Chem, 295 (6): (1754-1766). [PMID:31901078] |
4. Longchamp A et al.. (2018) Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.. Cell, 173 (117-129.e14). [PMID:29570992] |
5. Xiang HC et al.. (2019) AMPK activation attenuates inflammatory pain through inhibiting NF-?B activation and IL-1ß expression.. J Neuroinflammation, 16 (34). [PMID:30755236] |
6. Qin Y et al.. (2019) AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.. Mol Oncol, 13 (6): (1419-1432). [PMID:31033201] |
7. Sternlieb T et al.. (2021) An AMP-activated protein kinase complex with two distinctive alpha subunits is involved in nutritional stress responses in Trypanosoma cruzi.. PLoS Negl Trop Dis, 15 (5): (e0009435). [PMID:34029334] |
8. Wang L et al.. (2021) Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway.. Exp Ther Med, 21 (6): (560). [PMID:33850532] |
9. Schenke M et al.. (2020) Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays.. Toxins (Basel), 12 (5): [PMID:32344847] |
10. Qiang L et al.. (2017) Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.. Autophagy, 13 (12): (2086-2103). [PMID:28933598] |
11. Wang YY et al.. (2015) Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.. Drug Des Devel Ther, 9 (993-1026). [PMID:25733817] |
12. Hang W et al.. (2018) Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux.. Front Pharmacol, 9 (1121). [PMID:30337876] |
13. Wang K et al.. (2021) Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells.. Cell Death Differ, 28 (4): (1222-1236). [PMID:33097833] |
14. Park S et al.. (2014) Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats.. Brain Res Bull, 108C (18-26). [PMID:25149877] |
15. Erices R et al.. (2017) Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.. Oncotarget, 8 (13): (20865-20880). [PMID:28209916] |
16. Sun J et al.. (2019) CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy.. J Endocrinol, [PMID:30620716] |
17. Breckwoldt K et al.. (2017) Differentiation of cardiomyocytes and generation of human engineered heart tissue.. Nat Protoc, 12 (6): (1177-1197). [PMID:28492526] |
18. Liu J et al.. (2018) Effects of ginkgol C17:1 on cisplatin-induced autophagy and apoptosis in HepG2 cells.. Oncol Lett, 15 (1021-1029). [PMID:29399162] |
19. Brandão BB et al.. (2020) Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.. Proc Natl Acad Sci U S A, 117 (38): (23932-23941). [PMID:32900951] |
20. Ji R et al.. (2020) Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.. Int J Med Sci, 17 (7): (865-873). [PMID:32308539] |
21. Raulien N et al.. (2017) Fatty Acid Oxidation Compensates for Lipopolysaccharide-Induced Warburg Effect in Glucose-Deprived Monocytes.. Front Immunol, 8 (609). [PMID:28611773] |
22. Li F et al.. (2015) G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma.. PLoS One, 10 (9): (e0138390). [PMID:26397365] |
23. Gao P et al.. (2020) Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.. Diabetes, 69 (2): (165-180). [PMID:31712319] |
24. Liu J et al.. (2022) Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.. iScience, 25 (12): (105527). [PMID:36465125] |
25. Pecha S et al.. (2019) Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.. Sci Rep, 9 (9831). [PMID:31285568] |
26. Soh GH et al.. (2020) Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism.. Cell Rep, 31 (107487). [PMID:32268105] |
27. Blackmore K et al.. (2017) LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice.. Exp Biol Med (Maywood), 242 (15): (1490-1498). [PMID:28766983] |
28. Sun C et al.. (2017) MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential.. Autophagy, 13 (4): (730-738). [PMID:28121478] |
29. Hanada Y et al.. (2020) MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.. Nat Commun, 11 (5711). [PMID:33177519] |
30. Yang Y et al.. (2019) Mechanical stress protects against osteoarthritis via regulation of the AMPK/NF-?B signaling pathway.. J Cell Physiol, 234 (6): (9156-9167). [PMID:30311192] |
31. Niu C et al.. (2019) Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.. Autophagy, 15 (5): (843-870). [PMID:30653446] |
32. Lin MJ et al.. (2017) Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRa signaling pathway.. Oncotarget, 8 (65): (108802-108809). [PMID:29312569] |
33. Zhou Z et al.. (2016) Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression.. J Diabetes Res, 2016 (4847812). [PMID:27761470] |
34. Gong Y et al.. (2020) Metformin Inhibits Tumor Metastasis through Suppressing Hsp90a Secretion in an AMPKa1-PKC? Dependent Manner.. Cells, 9 [PMID:31936169] |
35. Rahimi S et al.. (2020) Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway.. Metab Brain Dis, 35 (7): (1135-1144). [PMID:32621159] |
36. Samanta J et al.. (2020) Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway.. Cardiovasc Toxicol, 20 (3): (261-280). [PMID:31571030] |
37. Yang X et al.. (2018) Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis.. Cell Death Dis, 9 (3): (264). [PMID:29449537] |
38. Wegscheid ML et al.. (2021) Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.. Cell Rep, 36 (109315). [PMID:34233200] |
39. Shi Y & Hou SA. (2021) Protective effects of metformin against myocardial ischemia-reperfusion injury via AMPK-dependent suppression of NOX4.. Mol Med Rep, 24 (4): [PMID:34396450] |
40. Ali Moussa HY et al.. (2022) Single Extracellular Vesicle Analysis Using Flow Cytometry for Neurological Disorder Biomarkers.. Front Integr Neurosci, 16 (879832). [PMID:35655952] |
41. Miao W et al.. (2016) Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCß2.. Int J Mol Sci, 17 (10): [PMID:27735862] |
42. Shati AA. (2020) Salidroside ameliorates diabetic nephropathy in rats by activating renal AMPK/SIRT1 signaling pathway.. J Food Biochem, 44 (4): (e13158). [PMID:32030786] |
43. Hunter KS et al.. (2021) Schistosome AMPK Is Required for Larval Viability and Regulates Glycogen Metabolism in Adult Parasites.. Front Microbiol, 12 (726465). [PMID:34539616] |
44. Saldivia M et al.. (2016) The AMPKa1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei.. Cell Rep, 17 (3): (660-670). [PMID:27732844] |
45. Fujihara S et al.. (2017) The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKa/mTOR pathway in vitro and in vivo.. Oncotarget, 8 (5): (8536-8549). [PMID:28052030] |
46. Cabrera-Cruz H et al.. (2020) The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment.. Am J Physiol Endocrinol Metab, 318 (2): (E237-E248). [PMID:31874063] |
47. Gao J et al.. (2018) Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway.. Front Mol Neurosci, 11 (267). [PMID:30104959] |
48. Chao Tian, Yuchao Feng, Tianhua Chen, Zuyang Zhang, Xiaojie He, Liangdong Jiang, Mingjiang Liu. (2023) EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK/ULK1 Pathway. Frontiers in Bioscience-Landmark, 28 (12): (324). [PMID:38179734] |
49. Xuan Ren, Jianchun Xu, Qingsong Xue, Yi Tong, Tairan Xu, Jinli Wang, Ting Yang, Yuan Chen, Deshun Shi, Xiangping Li. (2024) BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways. THERIOGENOLOGY, 215 (22): (10). [PMID:38000125] |
50. Yixin Sun, Danyang Guo, Saiding Yue, Mingyan Zhou, Dongxu Wang, Fengjiao Chen, Lingling Wang. (2023) Afzelin protects against doxorubicin-induced cardiotoxicity by promoting the AMPKα/SIRT1 signaling pathway. TOXICOLOGY AND APPLIED PHARMACOLOGY, (17): (116687). [PMID:37703929] |
51. Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Lee. (2023) Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement. CNS Neuroscience & Therapeutics, [PMID:37641913] |
52. Xingru Chen, Xiaolan Zhou, Xiaoqing Cheng, Liting Lin, Qi Wang, Ruoting Zhan, Qingguang Wu, Sijun Liu. (2023) Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. MOLECULES, 28 (8): (3482). [PMID:37110714] |
53. Haixu Wang, Yan Li, Chuang Liu, Tianxiang Lu, Qian Zhai, Hongna Wang, Jianfang Zhang. (2023) Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway. JOURNAL OF TOXICOLOGICAL SCIENCES, [PMID:36858637] |
54. Xing Zhang, Zhang-Tao Hu, Yu Li, Yan-Xue Li, Ming Xian, Song-Mao Guo, Jian-Hong Hu. (2022) Effect of Astragalus polysaccharides on the cryopreservation of goat semen. THERIOGENOLOGY, 193 (47). [PMID:36156425] |
55. Jiaqiao Li, Yameng Fan, Yan Zhang, Yamei Liu, Yan Yu, Mao Ma. (2022) Resveratrol Induces Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Cells by Activating the NGFR-AMPK-mTOR Pathway. Nutrients, 14 (12): (2413). [PMID:35745143] |
56. Xixi Song, Minghui Wang, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin. (2022) Ghrelin is a signal to facilitate the utilization of fatty acids and save glucose by the liver, skeletal muscle, and adipose tissues in chicks. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1867 (159081). [PMID:34856413] |
57. Tian-Yu Feng, Dong-Liang Lv, Xing Zhang, Ye-Qing Du, Yi-Tian Yuan, Mei-Jie Chen, Hua-Ming Xi, Yu Li, Ning Han, Jian-Hong Hu. (2020) Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation. REPRODUCTION IN DOMESTIC ANIMALS, 55 (12): (1714-1724). [PMID:32969084] |
58. Shanshan Wang, Qian Luo, Yuefang Zhou, Peihong Fan. (2019) CLG from Hemp Seed Inhibits LPS-Stimulated Neuroinflammation in BV2 Microglia by Regulating NF-κB and Nrf-2 Pathways. ACS Omega, 4 (15): (16517–16523). [PMID:31616830] |