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Dorzagliatin - 98%, high purity , CAS No.1191995-00-2, Allosteric modulator of Glucokinase

Moligand™

≥98%

CAS#: 1191995-00-2
Formula: C₂₂H₂₇ClN₄O₅
Molecular Weight: 462.93
PubChem CID: 57920094

Item Number

D413676

Grouped product items
SKU	Size	Availability	Price	Qty
D413676-5mg	5mg	In stock	$97.90
D413676-25mg	25mg	In stock	$303.90

Carbohydrate Metabolism Activators

View related series

Glucokinase Glucokinase Allosteric modulator Metabolic Enzyme/Protease

Basic Description

Synonyms	HY-109030 \| AKOS030527745 \| Sinogliatin \| (2S)-2-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2R)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide \| MFCD22376579 \| 1191995-00-2 \| BD167920 \| DB15123 \| HMS5552 \| HMS-5552 \| KBioSS_000661 \| (S)-2-(4
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of Glucokinase
Product Description	Information Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes. Targets glucokinase

ALogP

2.366

HBD Count

Rotatable Bond

Names and Identifiers

IUPAC Name	(2S)-2-[3-(2-chlorophenoxy)-5-oxo-2H-pyrrol-1-yl]-N-[1-[(2R)-2,3-dihydroxypropyl]pyrazol-3-yl]-4-methylpentanamide
INCHI	InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1
InChi Key	HMUMWSORCUWQJO-QAPCUYQASA-N
Canonical SMILES	CC(C)CC(C(=O)NC1=NN(C=C1)CC(CO)O)N2CC(=CC2=O)OC3=CC=CC=C3Cl
Isomeric SMILES	CC(C)C[C@@H](C(=O)NC1=NN(C=C1)C[C@H](CO)O)N2CC(=CC2=O)OC3=CC=CC=C3Cl
Alternate CAS	1191995-00-2
PubChem CID	57920094
MeSH Entry Terms	(2S)-2-(4-(2-Chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((2R)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide;Dorzagliatin;HMS5552;sinogliatin
Molecular Weight	462.93

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
K2222465	Certificate of Analysis	Nov 15, 2022	D413676
K2222516	Certificate of Analysis	Nov 15, 2022	D413676
K2222552	Certificate of Analysis	Nov 15, 2022	D413676

Solubility

Solubility (25°C) In vitro DMSO: 92 mg/mL (198.73 mM); Ethanol: 92 mg/mL (198.73 mM); Water: Insoluble;

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

198.734149871471

Water(mg / mL) Max Solubility

＜1

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE et al.. (2003) Allosteric activators of glucokinase: potential role in diabetes therapy.. Science, 301 (5631): (370-3). [PMID:12869762] [10.1021/op500134e]
2. Wang P, Liu H, Chen L, Duan Y, Chen Q, Xi S. (2017) Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus.. J Diabetes Res, 2017 (13): (5812607). [PMID:28191470] [10.1021/op500134e]
3. Bloomgarden Z. (2019) Glucokinase and the potential of glucokinase activation in type 2 diabetes.. J Diabetes, 11 (8): (626-627). [PMID:31013387] [10.1021/op500134e]
4. Zhu XX, Zhu DL, Li XY, Li YL, Jin XW, Hu TX, Zhao Y, Li YG, Zhao GY, Ren S et al.. (2018) Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection.. Diabetes Obes Metab, 20 (9): (2113-2120). [PMID:29707866] [10.1021/op500134e]
5. Toulis KA, Nirantharakumar K, Pourzitaki C, Barnett AH, Tahrani AA. (2020) Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments.. Drugs, 80 (5): (467-475). [PMID:32162273] [10.1021/op500134e]
6. Sharma P, Singh S, Sharma N, Singla D, Guarve K, Grewal AS. (2022) Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators.. J Diabetes Metab Disord, 21 (1): (1129-1137). [PMID:35673438] [10.1021/op500134e]

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Dorzagliatin - 98%, high purity , CAS No.1191995-00-2, Allosteric modulator of Glucokinase

Basic Description

Product Properties

Associated Targets(Human)