Basic Description

Synonyms	2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- \| (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-
Specifications & Purity	100 mg/mL in DMSO
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases)in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused byBacillus anthracis). It is also effective againstYersinia pestis. Treatment with doxycycline inhibits collagen synthesis.

Associated Targets(Human)

HEK293 (82097 Activities)

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

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ABCB11 Tchem Bile salt export pump (2311 Activities)

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Salmonella typhi (4293 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Streptomyces thermovulgaris (19 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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SARS-CoV-2 (38078 Activities)

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Sarm1 NAD(+) hydrolase SARM1 (23 Activities)

Discover Target: Sarm1

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
INCHI	InChI=1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1
InChi Key	PTNZGHXUZDHMIQ-CVHRZJFOSA-N
Canonical SMILES	CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
Isomeric SMILES	C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
Alternate CAS	100929-47-3；24390-14-5
PubChem CID	54685920
Molecular Weight	480.9

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO: 100mg/mL
Flash Point(°C)	87℃
Boil Point(°C)	762.6°C at 760 mmHg
Melt Point(°C)	195-201℃

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H400:Very toxic to aquatic life H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Tao Mi, Zhaoxia Zhang, Chenghao Zhanghuang, Liming Jin, Xiaojun Tan, Jiayan Liu, Xin Wu, Mujie Li, Jinkui Wang, Zhang Wang, Peng Guo, Dawei He. (2024) Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 964 (176291). [PMID:38158115]
2. Siyuan He, Jiafan Bai, Yuhao Liu, Yili Zeng, Linyu Wang, Xiangli Chen, Jianxin Wang, Jie Weng, Yuancong Zhao, Wenzhen Peng, Wei Zhi. (2023) A polyglutamic acid/tannic acid-based nano drug delivery system: Antibacterial, immunoregulation and sustained therapeutic strategies for oral ulcers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 648 (1): (123607). [PMID:37967688]
3. Xiangdong Zhang, Jian Zhang, Bowen Hou, Xueying Yang, Junlian Ren, Chen Shao. (2024) Efficient removal of oxytetracycline hydrochloride by ZIF-67 coated hollow spherical CuS (CuS-PVP@ZIF-67) under the synergistic effect of adsorption and PMS activation. APPLIED SURFACE SCIENCE, 643 (158663). [PMID:18636086]
4. Shiyong Chen, Jie Wang, Zhikun Shang, Yun Ding, Aiguo Hu. (2023) An electronic tongue based on conjugated polymers for the discrimination and quantitative detection of tetracyclines. ANALYST, 148 (20): (5152-5156). [PMID:37721048]
5. Yuzhi Liu, Bing Li, Ruili Li, Haodong Ji, Lan Song, Xiaoshan Zhu, Lu Jing, Xiaoning Liu, Yuefei Huang, Xiaofeng Wu. (2023) Simultaneous removal of microplastics and doxycycline and preparation of novel hollow carbon nanocakes by pyrolysis. CHEMICAL ENGINEERING JOURNAL, 472 (144999). [PMID:]
6. Shujuan Zhang, Yanpeng Mao, Lai Wei, Zhanlong Song, Xiqiang Zhao, Wenlong Wang. (2023) Full-value preparation of biochar and 2D N-doped CDs@ZIF-L from fermentation residues for sensitive sensing tetracyclines in food samples. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 676 (132073). [PMID:]
7. Pei Jia, Qiushuang Wu, Boyang Sun, Li Wang. (2023) Formic Acid-Regulated Defect Engineering in Zr-Based Metal-Organic Frameworks toward Fluorescence Sensor for Sensitive Detection of Chlortetracycline. Small, 19 (45): (2304096). [PMID:37415537]
8. Gang Tian, Jingyu Lin, Yu Zhou, Ziyu Huang, Xiaoping Wei, Jianping Li. (2023) Development of a molecularly imprinted photochemical sensor based on Bi2O3/TiO2 NTs heterojunction extended-gate field-effect transistor for the determination of trace neomycin. MICROCHEMICAL JOURNAL, 193 (108983). [PMID:]
9. Yi Xiaotong, He Jinmei, Wei Xinjing, Li Hongbin, Liu Xingyuan, Cheng Feng. (2023) A mussel-inspired multifunctional hydrogel reinforced by bacterial cellulose for wound healing: sustained drug release, enhanced adhesion and self-healing property. CELLULOSE, 30 (10): (6523-6538). [PMID:]
10. Fangfang Zhang, Jieni Wang, Yijun Tian, Chenxiao Liu, Shuqin Zhang, Leichang Cao, Yanmei Zhou, Shicheng Zhang. (2023) Effective removal of tetracycline antibiotics from water by magnetic functionalized biochar derived from rice waste. ENVIRONMENTAL POLLUTION, 330 (121681). [PMID:37087086]
11. Zhang Jinchi, Zhang Xiaowei, Li Wei, Guo Jing, Yang Liqun, Yan Guangqi. (2023) Poly (trimethylene carbonate)/doxycycline hydrochloride films in the treatment of Achilles tendon defect in rats. Frontiers in Bioengineering and Biotechnology, 11 [PMID:36911187]
12. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, 872 (162279). [PMID:36801336]
13. Kouhua Zhang, Yuting Wang, Ling Li, Li Jia. (2023) Fabrication of alginate-based nanofibers loaded with ZnO nanoparticles for adsorption of tetracyclines from environmental waters. Materials Today Communications, 34 (105214). [PMID:]
14. Yuanjie Teng, Zhenni Wang, Shaohua Zuo, Xin Li, Yinxin Chen. (2023) Identification of antibiotic residues in aquatic products with surface-enhanced Raman scattering powered by 1-D convolutional neural networks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 289 (122195). [PMID:36549071]
15. Min Liu, Hailan Qin, Haiming Xu, Zhongwei Zou, Chengming Deng, Dongsheng Xia, Qilin Yu, Yi Zheng, Dahong Chen. (2023) Confine activation peroxymonosulfate by surface oxygen vacancies of BiO1−xCl to boost its utilization rate. SEPARATION AND PURIFICATION TECHNOLOGY, 307 (122711). [PMID:]
16. Wanliang Liao, Yang Xu, Dingyun Li, Yixing Ye, Yuhan Ning, Weiping Wang, Ai-jun Wang. (2022) Facile room temperature synthesis of a NiFe2O4-based magnetic covalent organic framework for the extraction of tetracycline residues in environmental water samples prior to HPLC. Analytical Methods, 14 (47): (4938-4946). [PMID:36421069]
17. Junwei Wang, Ting Qin, Kai Chen, Liangkun Pan, Jun Xie, Bingwen Xi. (2022) Antimicrobial and Antivirulence Activities of Carvacrol against Pathogenic Aeromonas hydrophila. Microorganisms, 10 (11): (2170). [PMID:36363761]
18. Pengcheng Ma, Yuan Chen, Ning Shao, Junyu Zhang, Yueming Wu, Runhui Liu. (2022) Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance. CHINESE JOURNAL OF CHEMISTRY, 40 (24): (2947-2955). [PMID:]
19. Pei Chen, Wei Wang, Ningning Dong, Junjie Zhang, Tao Yang, Fatang Tan, Songwei Tan, Xinyun Wang, Xueliang Qiao, Po Keung Wong. (2022) Facile in-situ fabrication of ZnO2/CQD composites with promoted visible-light photocatalytic activities for organic degradation and bacterial inactivation. APPLIED SURFACE SCIENCE, 604 (154629). [PMID:]
20. Jin-Zhou Rui, Hu-Hong Peng, Yi-Xin Guan, Shan-Jing Yao. (2022) Preparation of ROS-responsive drug-loaded hydrogels applied in wound dressings using supercritical solvent impregnation. JOURNAL OF SUPERCRITICAL FLUIDS, 188 (105682). [PMID:]
21. Piaoyang Li, Danmei Rao, Yimei Wang, Xiaorong Hu. (2022) Adsorption characteristics of polythiophene for tetracyclines and determination of tetracyclines in fish and chicken manure by solid phase extraction-HPLC method. MICROCHEMICAL JOURNAL, 173 (106935). [PMID:]
22. Jia Wei, Yitao Liu, Jun Li, Yuhan Zhu, Hui Yu, Yongzhen Peng. (2019) Adsorption and co-adsorption of tetracycline and doxycycline by one-step synthesized iron loaded sludge biochar. CHEMOSPHERE, 236 (124254). [PMID:31306978]
23. Yifei Wang,Tengsheng Xie,Ji Yang,Meng Lei,Jing Fan,Zihui Meng,Min Xue,Lili Qiu,Fenglian Qi,Zhe Wang. (2019-05-20) Fast screening of antibiotics in milk using a molecularly imprinted two-dimensional photonic crystal hydrogel sensor.. Analytica chimica acta, 1070 (97-103). [PMID:31103172]

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Doxycycline Hydrochloride, Ready Made Solution , CAS No.10592-13-9

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