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DPQ - ≥99%, high purity , CAS No.129075-73-6

≥98%

CAS#: 129075-73-6
Formula: C₁₈H₂₆N₂O₂
Molecular Weight: 302.41
PubChem CID: 9948349

Item Number

D275293

Grouped product items
SKU	Size	Availability	Price
D275293-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
D275293-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$161.90
D275293-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$289.90
D275293-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$649.90
D275293-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90
D275293-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$948.90

Potent, selective PARP-1 inhibitor

View related series

Cell Cycle/DNA Damage Epigenetics PARP

Basic Description

Synonyms	32Z \| 5-[4-(1-Piperidinyl)-butyloxy]-1,2,3,4-tetrahydroisoquinolin-1-one \| EX-A8022 \| HY-114869 \| AC-10288 \| 5-(4-(Piperidin-1-yl)butoxy)-3,4-dihydroisoquinolin-1(2H)-one \| UNII-5007H57E2L \| 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]- \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Under the influence of ischemia, it is known that 3,4-dihydro-5- [4- (1-piperidinyl) butoxy] -1 (2H) - isoquinolinone (DPQ) can reduce PARP 1 (poly (ADP ribose) polymerase 1) - mediated cell apoptosis. It is considered a more effective inhibitor than the
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection.

Associated Targets(Human)

TRPM2 Tchem Transient receptor potential cation channel subfamily M member 2 (1 Activities)

Discover Target: TRPM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 (1 Activities)

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 Activities)

Discover Target: PARP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPM2 Tchem Transient receptor potential cation channel subfamily M member 2 (348 Activities)

Discover Target: TRPM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
INCHI	InChI=1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChi Key	RVOUDNBEIXGHJY-UHFFFAOYSA-N
Canonical SMILES	C1CCN(CC1)CCCCOC2=CC=CC3=C2CCNC3=O
Isomeric SMILES	C1CCN(CC1)CCCCOC2=CC=CC3=C2CCNC3=O
PubChem CID	9948349
Molecular Weight	302.41

Solubility

Soluble in DMSO to 10 mM

Melt Point(°C)

107-109 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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DPQ - ≥99%, high purity , CAS No.129075-73-6

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

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