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DQP 1105 - ≥97%(HPLC), high purity , CAS No.380560-89-4, Allosteric modulator of GluN2B;Allosteric modulator of GluN2C;Allosteric modulator of GluN2D
GluN2C/GluN2D-selective NMDA antagonist
Basic Description Synonyms CCG-268391 | methyl tosyl-L-argininate hydrochloride | T0330 | N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride | D92326 | N-a-Tosyl-L-arginine methyl ester HCl | (S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochlor Specifications & Purity Moligand™, ≥97%(HPLC) Biochemical and Physiological Mechanisms Noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50values are 2.7, 8.5, 121, 153, 198 and 206μM, respectively). Reduces f Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of GluN2B;Allosteric modulator of GluN2C;Allosteric modulator of GluN2D
Associated Targets(Human) Names and Identifiers InChi Key JIQFFACVQXXHMY-YDALLXLXSA-N Canonical SMILES O=C2C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2 Isomeric SMILES CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)OC.Cl PubChem CID 2723792 Molecular Weight 558.42
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 55.84, Max Conc. mM: 100
References 1. Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC et al. . (2011) Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.. Mol Pharmacol, 80 (5): (782-95). [PMID:21807990 ] [10.1021/op500134e ]
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G2213249