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DS2 - ≥97%(HPLC), high purity , CAS No.374084-31-8, Agonist of GABA A receptor δ; subunit
Positive allosteric modulator of GABAAreceptors; displays subunit selectivity
Basic Description Synonyms 374084-31-8 | DS2 | 4-chloro-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide | 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide | 4-chloro-N-(2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide | CHEMBL4212818 | MFCD01949910 | CBMicro_003068 | delta Specifications & Purity Moligand™, ≥97%(HPLC) Biochemical and Physiological Mechanisms Positive allosteric modulator of GABAAreceptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC50= 142 nM,in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABAArec Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of GABA A receptor δ; subunit
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-chloro-N-(2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide INCHI InChI=1S/C18H12ClN3OS/c19-13-8-6-12(7-9-13)18(23)21-17-16(14-4-3-11-24-14)20-15-5-1-2-10-22(15)17/h1-11H,(H,21,23) InChi Key AZKMWHRDICVYEI-UHFFFAOYSA-N Canonical SMILES C1=CC2=NC(=C(N2C=C1)NC(=O)C3=CC=C(C=C3)Cl)C4=CC=CS4 Isomeric SMILES C1=CC2=NC(=C(N2C=C1)NC(=O)C3=CC=C(C=C3)Cl)C4=CC=CS4 PubChem CID 979718 Molecular Weight 353.83
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 17.69, Max Conc. mM: 50
References 1. Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR. (2013) A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.. Br J Pharmacol, 168 (5): (1118-32). [PMID:23061935 ]
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