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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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D646229-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $201.90 | |
D646229-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $326.90 | |
D646229-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $704.90 | |
D646229-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,131.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC 50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC 50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively Form:Solid IC50& Target:IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-(5-oxo-2,4-dihydro-1H-chromeno[3,4-c]pyridine-3-carbonyl)benzoic acid |
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INCHI | InChI=1S/C20H15NO5/c22-18(12-5-7-13(8-6-12)19(23)24)21-10-9-14-15-3-1-2-4-17(15)26-20(25)16(14)11-21/h1-8H,9-11H2,(H,23,24) |
InChi Key | OXUKTNZACAKVRG-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CC2=C1C3=CC=CC=C3OC2=O)C(=O)C4=CC=C(C=C4)C(=O)O |
Isomeric SMILES | C1CN(CC2=C1C3=CC=CC=C3OC2=O)C(=O)C4=CC=C(C=C4)C(=O)O |
PubChem CID | 138393352 |
Molecular Weight | 349.34 |
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