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Transmembrane Transporters
Voltage-gated ion channels
Transient Receptor Potential channels (TRP)
DS88790512 , CAS No.D609986, Channel blocker of TRPC6

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DS88790512 , CAS No.D609986, Channel blocker of TRPC6

Moligand™

PubChem CID: 138319685

Item Number

D609986

Grouped product items
SKU	Size	Availability	Price	Qty
D609986-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609986-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

TRPC6 Channel blocker

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPC6

Associated Targets(Human)

TRPC6 Tchem Short transient receptor potential channel 6 (1 Activities)

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)

Discover Target: SCN5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-5-oxo-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
INCHI	InChI=1S/C22H29N3O2/c1-22-9-8-18(26)11-16(22)12-20(25-10-2-3-17(24)14-25)21(22)27-19-6-4-15(13-23)5-7-19/h4-7,16-17,20-21H,2-3,8-12,14,24H2,1H3/t16-,17+,20+,21-,22-/m0/s1
InChi Key	ZHIVJKLMVJUNNQ-HFQQBTNDSA-N
Canonical SMILES	C[C@]12CCC(=O)C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N
Isomeric SMILES	C[C@]12CCC(=O)C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N
PubChem CID	138319685

Database links

PubChem CID	138319685
ChEMBL Ligand	CHEMBL4127600
BindingDB Ligand	50273012

Certificates

Certificate of Analysis(COA)

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References

1. Motoyama K, Nagata T, Kobayashi J, Nakamura A, Miyoshi N, Kazui M, Sakurai K, Sakakura T. (2018) Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).. Bioorg Med Chem Lett, 28 (12): (2222-2227). [PMID:29752182] [10.1021/op500134e]

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