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DS88790512 , CAS No.D609986, Channel blocker of TRPC6

Moligand™

PubChem CID: 138319685

Item Number

D609986

Grouped product items
SKU	Size	Availability	Price	Qty
D609986-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609986-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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TRPC6 Channel blocker

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of TRPC6

Associated Targets

TRPC6 Tchem Short transient receptor potential channel 6 1 Activities

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN5A Tclin Sodium channel protein type 5 subunit alpha 0 Activities

Discover Target: SCN5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[(1R,2R,3aR,7aS)-2-[(3R)-3-aminopiperidin-1-yl]-7a-methyl-5-oxo-2,3,3a,4,6,7-hexahydro-1H-inden-1-yl]oxy]benzonitrile
INCHI	InChI=1S/C22H29N3O2/c1-22-9-8-18(26)11-16(22)12-20(25-10-2-3-17(24)14-25)21(22)27-19-6-4-15(13-23)5-7-19/h4-7,16-17,20-21H,2-3,8-12,14,24H2,1H3/t16-,17+,20+,21-,22-/m0/s1
InChi Key	ZHIVJKLMVJUNNQ-HFQQBTNDSA-N
Canonical SMILES	C[C@]12CCC(=O)C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N
Isomeric SMILES	C[C@]12CCC(=O)C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N
PubChem CID	138319685

PubChem CID

138319685

ChEMBL Ligand

CHEMBL4127600

BindingDB Ligand

50273012

References

1. Motoyama K, Nagata T, Kobayashi J, Nakamura A, Miyoshi N, Kazui M, Sakurai K, Sakakura T. (2018) Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).. Bioorg Med Chem Lett, 28 (12): (2222-2227). [PMID:29752182]

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DS88790512 , CAS No.D609986, Channel blocker of TRPC6

Basic Description

Associated Targets

TRPC6 Tchem Short transient receptor potential channel 6 1 Activities

SCN5A Tclin Sodium channel protein type 5 subunit alpha 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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