1. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N et al.. (2013) A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.. J Med Chem, 56 (12): (4990-5008). [PMID:23713581] |
2. Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.. Proc Natl Acad Sci USA, 104 (50): (19767-72). [PMID:18056643] |
3. Mak LH, Knott J, Scott KA, Scott C, Whyte GF, Ye Y, Mann DJ, Ces O, Stivers J, Woscholski R. (2012) Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.. Bioorg Med Chem, 20 (14): (4371-6). [PMID:22705189] |
4. Katherine A Rawls,P Therese Lang,Jun Takeuchi,Shinichi Imamura,Tyler D Baguley,Christoph Grundner,Tom Alber,Jonathan A Ellman. (2009-11-06) Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.. Bioorganic & medicinal chemistry letters, 19 ((24)): (6851-6854). [PMID:19889539] |
5. Lan Chen, Bo Zhou, Sheng Zhang, Li Wu, Yuehong Wang, Scott G Franzblau, Zhong-Yin Zhang,. (2010-12-01) Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.. ACS medicinal chemistry letters, 1 ((7)): ( 355-359 ). [PMID:21116447] |
6. Malamas MS, Sredy J, Moxham C, Katz A, Xu W, McDevitt R, Adebayo FO, Sawicki DR, Seestaller L, Sullivan D, Taylor JR.. (2000) Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.. J Med Chem, 43 (7): (1293-1310). [PMID:10753467] |
7. Wu S, Vossius S, Rahmouni S, Miletic AV, Vang T, Vazquez-Rodriguez J, Cerignoli F, Arimura Y, Williams S, Hayes T, Moutschen M, Vasile S, Pellecchia M, Mustelin T, Tautz L.. (2009) Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.. J Med Chem, 52 (21): (6716-6723). [PMID:19888758] |
8. Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY.. (2010) Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).. J Med Chem, 53 (6): (2482-2493). [PMID:20170098] |
9. Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, Tsang M, Tsang M.. (2009) Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.. Nat Chem Biol, 5 (9): (680-687). [PMID:19578332] |
10. Bu Y, Shi T, Meng M, Kong G, Tian Y, Chen Q, Yao X, Feng G, Chen H, Lu Z.. (2011) A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.. Bioorg Med Chem Lett, 21 (2): (874-878). [PMID:21169016] |
11. Bobkova EV, Liu WH, Colayco S, Rascon J, Vasile S, Gasior C, Critton DA, Chan X, Dahl R, Su Y, Sergienko E, Chung TD, Mustelin T, Page R, Tautz L.. (2011) Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.. ACS Med Chem Lett, 2 (2): (113-118). [PMID:21503265] |
12. Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY.. (2011) Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.. Bioorg Med Chem Lett, 21 (14): (4238-4242). [PMID:21669525] |
13. He Y, Xu J, Yu ZH, Gunawan AM, Wu L, Wang L, Zhang ZY.. (2013) Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.. J Med Chem, 56 (3): (832-842). [PMID:23305444] |
14. Li W, Li S, Higai K, Sasaki T, Asada Y, Ohshima S, Koike K.. (2013) Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.. Bioorg Med Chem Lett, 23 (21): (5836-5839). [PMID:24047800] |
15. Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY.. (2014) Therapeutic potential of targeting the oncogenic SHP2 phosphatase.. J Med Chem, 57 (15): (6594-6609). [PMID:25003231] |
16. Sasaki T, Li W, Higai K, Koike K.. (2015) Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.. Bioorg Med Chem Lett, 25 (9): (1979-1981). [PMID:25819098] |
17. He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY.. (2015) A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.. Bioorg Med Chem, 23 (12): (2798-2809). [PMID:25907364] |
18. Tautz L, Senis YA, Oury C, Rahmouni S.. (2015) Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.. Bioorg Med Chem, 23 (12): (2786-2797). [PMID:25921264] |
19. He R, Bai Y, Yu ZH, Wu L, Gunawan AM, Zhang ZY.. (2014) Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.. Medchemcomm, 5 (10): (1496-1499). [PMID:25505942] |
20. Abdjul DB, Yamazaki H, Kanno SI, Wewengkang DS, Rotinsulu H, Sumilat DA, Ukai K, Kapojos MM, Namikoshi M.. (2017) Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.. Bioorg Med Chem Lett, 27 (5): (1159-1161). [PMID:28189419] |
21. Xie J, Si X, Gu S, Wang M, Shen J, Li H, Shen J, Li D, Fang Y, Liu C, Zhu J.. (2017) Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.. J Med Chem, 60 (24): (10205-10219). [PMID:29155585] |
22. Zhang J, Sasaki T, Li W, Nagata K, Higai K, Feng F, Wang J, Cheng M, Koike K.. (2018) Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.. Bioorg Med Chem Lett, 28 (7): (1194-1197). [PMID:29525218] |
23. He R,Wang J,Yu ZH,Zhang RY,Liu S,Wu L,Zhang ZY. (2016) Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.. J Med Chem, 59 (19.0): (9094-9106). [PMID:27676368] |
24. Ishibashi, T T, Bottaro, D P DP, Chan, A A, Miki, T T and Aaronson, S A SA.. (1992) Expression cloning of a human dual-specificity phosphatase.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:1281549] |
25. Yuvaniyama, J J, Denu, J M JM, Dixon, J E JE and Saper, M A MA.. (1996) Crystal structure of the dual specificity protein phosphatase VHR.. Science (New York, N.Y.), (31): [PMID:8650541] |
26. Todd, J L JL, Tanner, K G KG and Denu, J M JM.. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.. The Journal of biological chemistry, (7): [PMID:10224087] |
27. Schumacher, Maria A MA, Todd, Jacob L JL, Rice, Adrian E AE, Tanner, Kirk G KG and Denu, John M JM.. (2002) Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.. Biochemistry, (5): [PMID:11863439] |
28. Zody, Michael C MC and 73 more authors.. (2006) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.. Nature, (20): [PMID:16625196] |
29. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460] |