Dutasteride - ≥99%, high purity , Steroid 5-alpha-reductase inhibitor, CAS No.164656-23-9, Steroid 5-alpha-reductase inhibitor

Item Number

D125351

• Synonyms: (5.alpha.,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide;dutasteride;Avodart; | DUTASTERIDE (EP MONOGRAPH) | DUTASTERIDE [ORANGE BOOK] | GG 745 | JALYN COMPONENT DUTASTERIDE | AKOS001174240 | BRD-K30373883-001-02-8 | CHEBI:521033 |
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: IC50 Value: Dutasteride(GG745) is a potent inhibitor of both 5alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.; in vitro: Dutasteride inhibited (3)H-T conversio
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Steroid 5-alpha-reductase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM.
Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).