Dutogliptin - 99%, high purity , Dipeptidyl peptidase IV inhibitor, CAS No.852329-66-9, Dipeptidyl peptidase IV inhibitor

Item Number

D646593

Grouped product items
SKU	Size	Availability	Price
D646593-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
D646593-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90
D646593-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90

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Basic Description

Synonyms	Dutogliptin \| CS-6633 \| [(2r)-1-{[(3r)-pyrrolidin-3-ylamino]acetyl}pyrrolidin-2-yl]boronic acid \| [(2R)-1-[2-[[(3R)-pyrrolidin-3-yl]amino]acetyl]pyrrolidin-2-yl]boronic acid \| ((R)-1-(((R)-pyrrolidin-3-yl)glycyl)pyrrolidin-2-yl)boronic acid \| DTXSID301005
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 ( DPP4 ) inhibitor for the treatment of type 2 diabetes mellitus.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Dipeptidyl peptidase IV inhibitor
Product Description	Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 ( DPP4 ) inhibitor for the treatment of type 2 diabetes mellitus. In Vivo Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a T max of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:DPP4

Associated Targets(Human)

DPP4 Tclin Dipeptidyl peptidase 4 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DPP9 Tchem Dipeptidyl peptidase 9 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DPP7 Tchem Dipeptidyl peptidase II (2000 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DPP8 Tchem Dipeptidyl peptidase VIII (2139 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DPP9 Tchem Dipeptidyl peptidase IX (1624 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(2R)-1-[2-[[(3R)-pyrrolidin-3-yl]amino]acetyl]pyrrolidin-2-yl]boronic acid
INCHI	InChI=1S/C10H20BN3O3/c15-10(7-13-8-3-4-12-6-8)14-5-1-2-9(14)11(16)17/h8-9,12-13,16-17H,1-7H2/t8-,9+/m1/s1
InChi Key	DVJAMEIQRSHVKC-BDAKNGLRSA-N
Canonical SMILES	B([C@@H]1CCCN1C(=O)CN[C@@H]2CCNC2)(O)O
Isomeric SMILES	B([C@@H]1CCCN1C(=O)CN[C@@H]2CCNC2)(O)O
PubChem CID	11253490
Molecular Weight	241.10

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Basic Description