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DX-2507, Antibody of Fc fragment of IgG receptor and transporter

Features and benefits

Item Number

Ab175515

Grouped product items
SKU	Size	Availability	Price	Qty
Ab175515-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,668.90
Ab175515-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,668.90

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Basic Description

Product Name	DX-2507
Grade	Moligand™
Action Type	ANTIBODY
Mechanism of action	Antibody of Fc fragment of IgG receptor and transporter

CAS	Ab175515

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

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1. Nixon AE, Chen J, Sexton DJ, Muruganandam A, Bitonti AJ, Dumont J, Viswanathan M, Martik D, Wassaf D, Mezo A et al.. (2015) Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.. Front Immunol, 6 (3): (176). [PMID:25954273]
2. Kenniston JA, Taylor BM, Conley GP, Cosic J, Kopacz KJ, Lindberg AP, Comeau SR, Atkins K, Bullen J, TenHoor C et al.. (2017) Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.. J Biol Chem, 292 (42): (17449-17460). [PMID:28878017]

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