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Dynole 34-2 - 97%, high purity , CAS No.1128165-88-7

≥97%

CAS#: 1128165-88-7
Formula: C₂₅H₃₆N₄O
Molecular Weight: 408.59
PubChem CID: 44157463

Item Number

D275968

Grouped product items
SKU	Size	Availability	Price
D275968-5mg	5mg	In stock	$117.90
D275968-10mg	10mg	In stock	$197.90
D275968-25mg	25mg	In stock	$395.90
D275968-50mg	50mg	In stock	$632.90
D275968-100mg	100mg	In stock	$1,139.90

Potent dynamin I and dynamin II inhibitor

Basic Description

Synonyms	2-Cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]acrylamide；(Z)-2-cyano-3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-N-octylacrylamide
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Potent, cell-permeable dynamin I and dynamin II inhibitor (IC 50 values are 1.3 and 14.2 μM for inhibition of dynamin I and II GTPase, respectively). Targets the GTPase domain at an allosteric site.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

DNM1 Tbio Dynamin-1 (215 Activities)

Discover Target: DNM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DNM2 Tchem Dynamin-2 (62 Activities)

Discover Target: DNM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(E)-2-cyano-3-[1-[3-(dimethylamino)propyl]indol-3-yl]-N-octylprop-2-enamide
INCHI	InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+
InChi Key	MYIMRONQBLZJFI-DYTRJAOYSA-N
Canonical SMILES	CCCCCCCCNC(=O)C(=CC1=CN(C2=CC=CC=C21)CCCN(C)C)C#N
Isomeric SMILES	CCCCCCCCNC(=O)/C(=C/C1=CN(C2=CC=CC=C21)CCCN(C)C)/C#N
PubChem CID	44157463
Molecular Weight	408.59

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
I2202499	Certificate of Analysis	Jun 13, 2023	D275968
I2202500	Certificate of Analysis	Jun 13, 2023	D275968
I2202501	Certificate of Analysis	Jun 13, 2023	D275968
I2202495	Certificate of Analysis	Jun 13, 2023	D275968
I2202244	Certificate of Analysis	Jun 12, 2023	D275968

References

1. Lynn KS et al.. (2021) Asymmetric distribution of dynamin-2 and ß-catenin relative to tight junction spikes in alveolar epithelial cells.. Tissue Barriers, (1929786). [PMID:34107845]
2. Stallaert W et al.. (2018) Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling.. Sci Signal, 11 (541): [PMID:30065026]
3. Ivanova D et al.. (2020) CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.. Cell Rep, 30 (7): (2444-2459.e7). [PMID:32075774]
4. Štimac I et al.. (2021) Dynamin Inhibitors Prevent the Establishment of the Cytomegalovirus Assembly Compartment in the Early Phase of Infection.. Life (Basel), 11 (9): [PMID:34575026]
5. Eppler FJ et al.. (2017) Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion.. PLoS One, 12 (3): (e0172443). [PMID:28273099]
6. González-Jamett AM et al.. (2017) Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.. Sci Rep, 7 (4580). [PMID:28676641]
7. Wang D et al.. (2020) ERK is involved in the differentiation and function of dimethyl sulfoxide-induced HL-60 neutrophil-like cells, which mimic inflammatory neutrophils.. Int Immunopharmacol, 84 (106510). [PMID:32361568]
8. de la Vega M et al.. (2011) Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.. Retrovirology, 8 (99). [PMID:22145853]
9. Richard JP et al.. (2011) Intracellular curvature-generating proteins in cell-to-cell fusion.. Biochem J, 440 (2): (185-93). [PMID:21895608]
10. Szymanska E et al.. (2016) Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway.. Cell Signal, 28 (160-71). [PMID:26475677]
11. Kockx M et al.. (2014) Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.. PLoS One, 9 (10): (e111186). [PMID:25347775]

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