Potent, cell-permeable dynamin I and dynamin II inhibitor (IC 50 values are 1.3 and 14.2 μM for inhibition of dynamin I and II GTPase, respectively). Targets the GTPase domain at an allosteric site.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Lynn KS et al.. (2021) Asymmetric distribution of dynamin-2 and ß-catenin relative to tight junction spikes in alveolar epithelial cells.. Tissue Barriers, (1929786). [PMID:34107845]
2.Stallaert W et al.. (2018) Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling.. Sci Signal, 11 (541):[PMID:30065026]
3.Ivanova D et al.. (2020) CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.. Cell Rep, 30 (7):(2444-2459.e7). [PMID:32075774]
4.Štimac I et al.. (2021) Dynamin Inhibitors Prevent the Establishment of the Cytomegalovirus Assembly Compartment in the Early Phase of Infection.. Life (Basel), 11 (9):[PMID:34575026]
5.Eppler FJ et al.. (2017) Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion.. PLoS One, 12 (3):(e0172443). [PMID:28273099]
6.González-Jamett AM et al.. (2017) Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.. Sci Rep, 7 (4580). [PMID:28676641]
7.Wang D et al.. (2020) ERK is involved in the differentiation and function of dimethyl sulfoxide-induced HL-60 neutrophil-like cells, which mimic inflammatory neutrophils.. Int Immunopharmacol, 84 (106510). [PMID:32361568]
8.Szymanska E et al.. (2016) Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway.. Cell Signal, 28 (160-71). [PMID:26475677]
9.de la Vega M et al.. (2011) Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.. Retrovirology, 8 (99). [PMID:22145853]
10.Richard JP et al.. (2011) Intracellular curvature-generating proteins in cell-to-cell fusion.. Biochem J, 440 (2):(185-93). [PMID:21895608]
11.Kockx M et al.. (2014) Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.. PLoS One, 9 (10):(e111186). [PMID:25347775]
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I2202499