dysiherbaine , CAS No.185245-55-0, Agonist of GluK1;Agonist of GluK2;Agonist of GluK3;Agonist of GluK4;Agonist of GluK5

Item Number
D610035
Grouped product items
SKUSizeAvailabilityPrice Qty
D610035-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
D610035-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,000.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GluK1;Agonist of GluK2;Agonist of GluK3;Agonist of GluK4;Agonist of GluK5

Associated Targets(Human)

GRIK4 Tclin Glutamate receptor ionotropic, kainate 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK5 Tclin Glutamate receptor ionotropic, kainate 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK1 Tclin Glutamate receptor ionotropic, kainate 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK2 Tclin Glutamate receptor ionotropic, kainate 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK3 Tclin Glutamate receptor ionotropic, kainate 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIK1 Tclin Glutamate receptor ionotropic kainate 1 (340 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Grik2 Glutamate receptor ionotropic kainate 2 (298 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Glutamate receptor ionotropic kainate 1 antagonistANTAGONISTALA1918Glutamate receptor ionotropic kainate 1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3] , [4]


Names and Identifiers

IUPAC Name (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)-hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid
INCHI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
InChi Key YUSZFKPLFIQTGF-FDNSHYBFSA-N
Canonical SMILES CN[C@@H]1[C@H](O)CO[C@H]2[C@@H]1O[C@@](C2)(C[C@@H](C(=O)O)N)C(=O)O
Isomeric SMILES CN[C@@H]1[C@@H](CO[C@H]2[C@@H]1O[C@@](C2)(C[C@@H](C(=O)O)N)C(=O)O)O
PubChem CID 9839436

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Sakai R, Swanson GT, Shimamoto K, Green T, Contractor A, Ghetti A, Tamura-Horikawa Y, Oiwa C, Kamiya H.  (2001)  Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea..  J Pharmacol Exp Ther,  296  (2): (650-8).  [PMID:11160654] [10.1021/op500134e]

Solution Calculators