J2221226Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | BRD-K52053379-001-02-0 | MFCD00016441 | (E)-2'-Hydroxychalcone | SMR000112946 | NCGC00017803-06 | NSC 18939 | H-4450 | NCGC00017803-03 | o-Cinnamoylphenol | PD001173 | 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one | (E)-1-(2-hydroxyphenyl)-3-phenyl-prop-2-e |
|---|---|
| Specifications & Purity | ≥96% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | (E)-2′-Hydroxychalcone is a chalcone derivative. Chalcone derivatives have exhibited unexpectedly good activity as angiogenesis inhibitors. Experimental results indicate that the flavonoids chalcone, 2-hydroxychalcone, and quercetin present in our daily foods have an inhibitory effect on oral carcinogenesis initiated with 4-NQO, and such a modifying effect may be related partly to the suppression of cell proliferation. |
Associated Targets(Human)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
VDR Tclin Vitamin D receptor (26531 Activities)
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
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XDH Tclin Xanthine dehydrogenase (1038 Activities)
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PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
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BCHE Tclin Butyrylcholinesterase (7174 Activities)
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PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
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FLT3 Tclin Tyrosine-protein kinase receptor FLT3 (13481 Activities)
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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
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Homo sapiens (32628 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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MCF7 (126967 Activities)
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SK-N-MC (815 Activities)
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THP-1 (11052 Activities)
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TK-10 (45540 Activities)
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HCT-116 (91556 Activities)
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HepG2 (196354 Activities)
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PBMC (10003 Activities)
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MV4-11 (7307 Activities)
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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
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POLI Tchem DNA polymerase iota (116820 Activities)
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ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)
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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
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HSC-2 (771 Activities)
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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
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GMNN Tbio Geminin (128009 Activities)
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APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G (12481 Activities)
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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)
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ATXN2 Tbio Ataxin-2 (54410 Activities)
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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
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PTGS2 Tclin Cyclooxygenase (1258 Activities)
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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
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Associated Targets(non-human)
Abcc1 Multidrug resistance-associated protein 1 (42 Activities)
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Abcb1b P-glycoprotein 1 (174 Activities)
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Cryz Quinone oxidoreductase (288 Activities)
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Staphylococcus aureus (210822 Activities)
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Mycobacterium tuberculosis (203094 Activities)
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Trypanosoma cruzi (99888 Activities)
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Rattus norvegicus (775804 Activities)
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3T3-L1 (3664 Activities)
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RAW264.7 (28094 Activities)
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L929 (3802 Activities)
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Luciferin 4-monooxygenase (66902 Activities)
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PYK Pyruvate kinase (6726 Activities)
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Culex quinquefasciatus (137 Activities)
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Triosephosphate isomerase, glycosomal (493 Activities)
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Mapt Microtubule-associated protein tau (6 Activities)
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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
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Rorc Nuclear receptor ROR-gamma (89407 Activities)
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FTL Ferritin light chain (43324 Activities)
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NS1 Nonstructural protein 1 (33327 Activities)
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TUBA4A Tubulin alpha 4a (17 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one |
|---|---|
| INCHI | InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+ |
| InChi Key | AETKQQBRKSELEL-ZHACJKMWSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2O |
| Isomeric SMILES | C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2O |
| PubChem CID | 638276 |
| Molecular Weight | 224.25 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Solubility | Soluble in Acetone, Chloroform, Dichloromethane, Ethyl Acetate and Methanol |
|---|---|
| Melt Point(°C) | 84-85° C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
Related Documents
Citations of This Product
| 1. Changjiao Shang, Yajie Zhang, Chaofan Sun, Lingling Wang. (2022) Tactfully improve the antioxidant activity of 2′-hydroxychalcone with the strategy of substituent, solvent and intramolecular hydrogen bond effects. JOURNAL OF MOLECULAR LIQUIDS, 362 (119748). [PMID:] [10.1016/j.molliq.2022.119748] |
References
| 1. Changjiao Shang, Yajie Zhang, Chaofan Sun, Lingling Wang. (2022) Tactfully improve the antioxidant activity of 2′-hydroxychalcone with the strategy of substituent, solvent and intramolecular hydrogen bond effects. JOURNAL OF MOLECULAR LIQUIDS, 362 (119748). [PMID:] [10.1016/j.molliq.2022.119748] |