Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 2'-Hydroxychalcone|1214-47-7|888-12-0|o-Hydroxychalcone|(E)-2'-Hydroxychalcone|1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one|Chalcone, 2'-hydroxy-|1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one|(E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one|(2E)-1-(2-hydroxyp |
|---|---|
| Specifications & Purity | ≥96% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | (E)-2′-Hydroxychalcone is a chalcone derivative. Chalcone derivatives have exhibited unexpectedly good activity as angiogenesis inhibitors. Experimental results indicate that the flavonoids chalcone, 2-hydroxychalcone, and quercetin present in our daily foods have an inhibitory effect on oral carcinogenesis initiated with 4-NQO, and such a modifying effect may be related partly to the suppression of cell proliferation. |
Associated Targets
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities
GMNN Tbio Geminin 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
RORC Tchem Nuclear receptor ROR-gamma 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
VDR Tclin Vitamin D3 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ABCB1 Tchem Multidrug resistance protein 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
FTL Tbio Ferritin light chain 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TUBA4A Tchem Tubulin alpha-4A chain 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
POLI Tchem DNA polymerase iota 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
CRYZ Tbio Quinone oxidoreductase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ATXN2 Tbio Ataxin-2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
XDH Tclin Xanthine dehydrogenase/oxidase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ABCG2 Tchem ATP-binding cassette sub-family G member 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
GNAS Tbio Protein ALEX 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TARDBP Tchem TAR DNA-binding protein 43 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MAPT Tclin Microtubule-associated protein tau 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
BCHE Tclin Cholinesterase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
KDM4A Tchem Lysine-specific demethylase 4A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ABCC1 Tchem Multidrug resistance-associated protein 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Names and Identifiers
| IUPAC Name | (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one |
|---|---|
| INCHI | InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+ |
| InChi Key | AETKQQBRKSELEL-ZHACJKMWSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2O |
| Isomeric SMILES | C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2O |
| PubChem CID | 638276 |
| Molecular Weight | 224.25 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2221226 | Certificate of Analysis | Aug 03, 2022 | E340666 |
| J2221228 | Certificate of Analysis | Aug 03, 2022 | E340666 |
| J2221351 | Certificate of Analysis | Aug 03, 2022 | E340666 |
Chemical and Physical Properties
| Solubility | Soluble in Acetone, Chloroform, Dichloromethane, Ethyl Acetate and Methanol |
|---|---|
| Melt Point(°C) | 84-85° C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |