Type III antiarrhythmic drug that blocks ion channels encoded by the ether-a-go-go related gene (ERG1 or KCNH1). Blocks channels in the open configuration with little effect on the channels in the closed configuration.
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Associated Targets(Human)
KCNH2TclinPotassium voltage-gated channel subfamily H member 2 (16 Activities)
1.Zhang F et al.. (2022) High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus.. Front Cell Dev Biol, 10 (1038867). [PMID:36274846]
2.Greenwood IA et al.. (2009) Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset.. J Physiol, 587 (Pt 10):(2313-26). [PMID:19332483]
3.Fukushiro-Lopes DF et al.. (2018) Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.. Oncotarget, 9 (3):(3321-3337). [PMID:29423049]
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