Basic Description

Synonyms	Brivudine \| 69304-47-8 \| BVDU \| (E)-5-(2-Bromovinyl)-2'-deoxyuridine \| Brivudin \| Helpin \| Zostex \| Bromovinyldeoxyuridine \| Brivudine [INN] \| 5-BROMOVINYLDEOXYURIDINE \| (E)-5-(2-Bromovinyl)-deoxyuridine \| RP101 \| RP-101 \| DTXSID0045755 \| Brivudine (INN) \| NSC-633770 \| 5-((E)-2-bromovin
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Pyrimidine nucleoside analog. Antiviral agent (IC 50 values are 76 nM and 1.4 μM for herpesvirus and HIV respectively). Blocks DNA polymerase. Binds to heat shock protein HSPB1 and inhibits interaction with its binding partners. Shows anticancer effects i
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Brivudine is an antiviral coumpound. An exceptionally potent inhibitor of Herpes simplex virus type

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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TK1 Tchem Thymidine kinase, cytosolic (627 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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CCRF-CEM (65223 Activities)

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CCRF-HSB-2 (188 Activities)

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MOLT-4F (93 Activities)

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MRC5 (9203 Activities)

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OST (42 Activities)

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P3HR-1 (52 Activities)

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Raji (5516 Activities)

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Ramos (1218 Activities)

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A549 (127892 Activities)

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E6SM (1586 Activities)

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HEL (6614 Activities)

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HEL 299 (144 Activities)

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HEp-2 (3859 Activities)

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Cell line (371 Activities)

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Jurkat (10389 Activities)

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M21 (1715 Activities)

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HeLa (62764 Activities)

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Mo (135 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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Associated Targets(non-human)

TK Thymidine kinase (276 Activities)

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Cruzipain (33337 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Plasmodium falciparum (966862 Activities)

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Human alphaherpesvirus 2 (4932 Activities)

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Human gammaherpesvirus 4 (1538 Activities)

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Human respirovirus 3 (1674 Activities)

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Influenza B virus (2113 Activities)

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Human alphaherpesvirus 3 (4092 Activities)

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Cytomegalovirus (1023 Activities)

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Human betaherpesvirus 5 (5122 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Mus musculus (284745 Activities)

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Vaccinia virus (4609 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Moloney murine sarcoma virus (182 Activities)

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Human adenovirus 2 (239 Activities)

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Reovirus sp. (323 Activities)

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Sindbis virus (1599 Activities)

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Vesicular stomatitis virus (4460 Activities)

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Influenza A virus (11224 Activities)

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Punta Toro virus (1491 Activities)

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Human immunodeficiency virus 2 (5592 Activities)

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Coxsackievirus B4 (2249 Activities)

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Respiratory syncytial virus (3434 Activities)

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BSC-1 (357 Activities)

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E1 SM (3 Activities)

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FM3A (1296 Activities)

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L1210 (27553 Activities)

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Vero (26788 Activities)

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NIH3T3 (5395 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Felid alphaherpesvirus 1 (460 Activities)

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Feline coronavirus (624 Activities)

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Human gammaherpesvirus 8 (66 Activities)

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Mammalian orthoreovirus 1 (1523 Activities)

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Macacine alphaherpesvirus 1 (205 Activities)

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SARS-CoV-2 (38078 Activities)

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Vero C1008 (1716 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-[(E)-2-bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
INCHI	InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1
InChi Key	ODZBBRURCPAEIQ-PIXDULNESA-N
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O
Isomeric SMILES	C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)/C=C/Br)CO)O
WGK Germany	3
RTECS	YU7355000
PubChem CID	446727
Molecular Weight	333.14
Reaxy-Rn	758153

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Heat Sensitive
Specific Rotation[α]	9° (C=1,MeOH)
Melt Point(°C)	166 °C(dec.)

Safety and Hazards(GHS)

WGK Germany	3
RTECS	YU7355000
Reaxy-Rn	758153
Merck Index	1378

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(E)-5-(2-Bromovinyl)-2'-deoxyuridine - 10mM in DMSO, high purity , CAS No.69304-47-8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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