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E-64c - 10mM in DMSO, high purity , CAS No.76684-89-4
E-64 ( ab141418 ) derivative. Irreversible cysteine protease inhibitor.
Basic Description Synonyms 76684-89-4 | e-64c | Loxistatin acid | E 64c | EP 475 | E-64-c | NSC 694279 | MLS000028693 | (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid | SMR000058872 | N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine | (2S,3S)-t Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Synthetic analog of E-64 , a potent, irreversible cysteine protease inhibitor isolated from Aspergillus japonicus . Effective calpain inhibitor, which also inhibits cathepsin B, cathepsin H, and cathepsin L. Inhibits calpain activity in intact Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid INCHI InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1 InChi Key SCMSYZJDIQPSDI-SRVKXCTJSA-N Canonical SMILES CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1C(O1)C(=O)O Isomeric SMILES CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1[C@H](O1)C(=O)O WGK Germany 3 RTECS RR0404200 PubChem CID 123664 Molecular Weight 314.38
Safety and Hazards(GHS) WGK Germany 3 RTECS RR0404200
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