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E-64d - protease inhibitor，98%, high purity , CAS No.88321-09-9, Inhibitor of cathepsin G
Irreversible cell-permeable cathepsin B and L inhibitor
Basic Description Synonyms Aloxistatin|88321-09-9|Loxistatin|E-64D|E 64d|Aloxistatin [INN]|Aloxistatina|Aloxistatine|Aloxistatinum|E64d|EST|L5W337AOUR|CHEMBL63440|Ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate|MLS000028372|E-64-d|NSC-694281|SMR0 Specifications & Purity protease inhibitor，98% Storage Temp Store at -20°C Shipped In Dry ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of cathepsin G
Names and Identifiers IUPAC Name ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate INCHI InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 InChi Key SRVFFFJZQVENJC-IHRRRGAJSA-N Canonical SMILES CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C Isomeric SMILES CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C PubChem CID 65663 Molecular Weight 342.43
Chemical and Physical Properties Specific Rotation[α] 49° (C=1,MeOH) Melt Point(°C) 126 °C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, Tamai M, Hanada K. (1982) L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.. Biochem J, 201 (1): (189-98). [PMID:7044372 ] 2. Meara JP, Rich DH. (1996) Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors.. J Med Chem, 39 (17): (3357-66). [PMID:8765519 ] 3. Qin Y et al.. (2019) Redox-Mediated Endocytosis of a Receptor-Like Kinase during Distal Stem Cell Differentiation Depends on Its Tumor Necrosis Factor Receptor Domain.. Plant Physiol, 181 (3): (1075-1095). [PMID:31471454 ]
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