(-)-Epigallocatechin gallate - 98%, high purity , CAS No.989-51-5, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
(-)-Epigallocatechin gallate - 98%, high purity , CAS No.989-51-5, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
β-secretase (BACE1) inhibitor (IC50= 1.6μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ,α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate de
Storage Temp
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST, INHIBITOR
Mechanism of action
Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
Product Description
(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS). An inhibitor of Bcl-2 and NOS2
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