Grouped product items

SKU

Size

Availability

Price

Qty

E156155-5g

In stock

$12.90

E156155-10g

10g

Available within 8-12 weeks(?)

$18.90

E156155-25g

25g

In stock

$36.90

E156155-100g

100g

Available within 8-12 weeks(?)

$129.90

E156155-500g

500g

Available within 4-8 weeks(?)

$584.90

Basic Description

Synonyms	2-methyl-3-oxobutanoic acid ethyl ester \| 2-methyl-3-oxo-butanoic acid ethyl ester \| cid_701 \| NCGC00090968-02 \| Ethyl 2-methylacetoacetate \| ethyl 2-methyl-acetoacetate \| Ethyl 2-methylaceto-acetate \| Ethyl 2-methyl-3-oxobutanoate \| BDBM74254 \| E-8300 \|
Specifications & Purity	≥95%(GC)
Storage Temp	Argon charged
Shipped In	Normal
Product Description	• Ethyl 2-methylacetoacetate is used as a substrate in the rhenium-catalyzed synthesis of multisubstituted aromatic compounds. • It can be employed in the synthesis of coumarin derivatives via Pechmann condensation. • It undergoes dehydration to yield conjugated alkynyl and allenyl esters. • It is also used in the total synthesis of chlorotonil A,yangjinhualine A, (+)- and (−)-saudin.

Associated Targets(Human)

POLH Tchem DNA polymerase eta (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WRN Tbio Werner syndrome ATP-dependent helicase (0 Activities)

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POLK Tbio DNA polymerase kappa (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (8653 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Catharanthus roseus (29 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Oryctolagus cuniculus (11301 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179540
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179540
IUPAC Name	ethyl 2-methyl-3-oxobutanoate
INCHI	InChI=1S/C7H12O3/c1-4-10-7(9)5(2)6(3)8/h5H,4H2,1-3H3
InChi Key	FNENWZWNOPCZGK-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C(C)C(=O)C
Isomeric SMILES	CCOC(=O)C(C)C(=O)C
WGK Germany	3
PubChem CID	701
Molecular Weight	144.17
Beilstein	1071740
Reaxy-Rn	1071742

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
B2216334	Certificate of Analysis	Feb 09, 2022	E156155
G2311256	Certificate of Analysis	Mar 02, 2021	E156155

Chemical and Physical Properties

Solubility	Insoluble in water
Sensitivity	Air sensitive
Refractive Index	1.418
Flash Point(°F)	145.4 °F
Flash Point(°C)	62°C(lit.)
Boil Point(°C)	185°C(lit.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	1071742

FAQs and Articles

FAQ

Aldol Condensation Reaction

Categories: Technical articles

Tags:

Organic block Building Blocks Catalytic agent Inorganic catalyst Aldol condensation reaction

References

1. T Kuramoto,K Iwamoto,M Izumi,M Kirihata,F Yoshizako. (1999-05-05) Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by Chlorella.. Bioscience, biotechnology, and biochemistry, 63 ((3)): (598-601). [PMID:10227152]
2. Yinan Chen,Jun Zhang,Lei Guo,Lei Liu,Jingran Wen,Lu Xu,Min Yan,Zuofeng Li,Xiaoyan Zhang,Peng Nan,Jinling Jiang,Jun Ji,Jianian Zhang,Wei Cai,Huisheng Zhuang,Yan Wang,Zhenggang Zhu,Yingyan Yu. (2016-09-03) A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis.. Oncotarget, 7 ((52)): (87496-87510). [PMID:27589838]
3. Michal Plž,Tatiana Petrovičová,Martin Rebroš. (2020-09-24) Semi-Continuous Flow Biocatalysis with Affinity Co-Immobilized Ketoreductase and Glucose Dehydrogenase.. Molecules (Basel, Switzerland), 25 ((18)): [PMID:32961948]
4. K Iwamoto,T Kuramoto,M Izumi,M Kirihata,T Dohmaru,F Yoshizako. (2000-04-15) Asymmetric reduction of ethyl 2-methyl e-oxobutanoate by fungi.. Bioscience, biotechnology, and biochemistry, 64 ((1)): (194-197). [PMID:10766507]

Solution Calculators

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Ethyl 2-Methylacetoacetate - >95.0%(GC), high purity , CAS No.609-14-3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator