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E6446 - 99%, high purity , CAS No.1219925-73-1
Basic Description Specifications & Purity ≥99% Biochemical and Physiological Mechanisms E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
E6446 E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro.
Targets
TLR7 ; TLR9 ; DNA-TLR9
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole INCHI InChI=1S/C27H35N3O3/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30/h7-12,21H,1-6,13-20H2 InChi Key YMYJXFUPMPMETB-UHFFFAOYSA-N Canonical SMILES C1CCN(C1)CCCOC2=CC=C(C=C2)C3=NC4=C(O3)C=C(C=C4)OCCCN5CCCC5 Isomeric SMILES C1CCN(C1)CCCOC2=CC=C(C=C2)C3=NC4=C(O3)C=C(C=C4)OCCCN5CCCC5 PubChem CID 45102599 Molecular Weight 449.59
Chemical and Physical Properties Solubility Solubility (25°C) In vitro Ethanol: 90 mg/mL (200.18 mM); DMSO: Insoluble; Water: Insoluble;
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