E7046 (ER-886406) - 10mM in DMSO, high purity , CAS No.1369489-71-3

Item Number

E421400

• Synonyms: 1369489-71-3 | E7046 | E-7046 | ER-886046 | PALUPIPRANT | YWY620GU8I | Benzoic acid, 4-((1S)-1-(((3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazol-4-yl)carbonyl)amino)ethyl)- | (S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: E7046 (ER-886406) is a selective inhibitor of the prostaglandin E₂ (PGE₂) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

E7046 (ER-886406) E7046 (ER-886406) is a selective inhibitor of the prostaglandin E 2 (PGE 2 ) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.

Targets

EP4 (Cell-free assay); EP4 (Cell-free assay) 13.5nM; 23.14 nM(Ki)

In vitro

E7046 has specific and potent inhibitory activity on PGE₂-mediated pro-tumor myeloid cell differentiation and activation.

In vivo

E7046 treatment reduces the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8⁺ T cells.

Cell Research(from reference)

Cell lines：Monocytes 

Concentrations：10,100,300,1000,or 3000 nM 

Incubation Time：7d