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EC 144 - ≥98%(HPLC), high purity , CAS No.911397-80-3
High affinity, potent and selective Hsp90 inhibitor
Basic Description Synonyms 5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms High affinity, potent and selective Hsp90 inhibitor (Ki= 0.2 nM and IC50= 1.1 nM). Exhibits selectivity for Hsp90 over Grp94 and TRAP1 (Kivalues are 61 and 255 nM respectively) and has no effect (IC50>10μM) against a panel of 285 kinases. Degrades Her-2 i Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 5-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]-2-methylpent-4-yn-2-ol INCHI InChI=1S/C21H24ClN5O2/c1-12-9-24-15(13(2)17(12)29-5)11-27-10-14(7-6-8-21(3,4)28)16-18(22)25-20(23)26-19(16)27/h9-10,28H,8,11H2,1-5H3,(H2,23,25,26) InChi Key VOASEWXFCTZRDF-UHFFFAOYSA-N Canonical SMILES CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)C#CCC(C)(C)O Isomeric SMILES CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)C#CCC(C)(C)O PubChem CID 11517212 Molecular Weight 413.9
Chemical and Physical Properties Solubility Solvent:ethanol, Max Conc. mg/mL: 2.07, Max Conc. mM: 5; Solvent:DMSO, Max Conc. mg/mL: 41.39, Max Conc. mM: 100
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